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DOI: 10.1055/s-0043-1776747
Mandibular Advancement Appliances in Pediatric Obstructive Sleep Apnea: An Umbrella Review
Abstract
Introduction Obstructive sleep apnea (OSA) is defined as intermittent partial or complete collapse of the upper airway during sleep. It is a common condition in childhood, with an incidence ranging from 1.2% to 5.7%, and it can harm several aspects of children's life, such as cognitive, metabolic and cardiovascular functions, among others.
There are treatment options, such as adenotonsillectomy, myofunctional therapy, mandibular advancement appliances (MAAs), rapid maxillary expansion, and positive airway pressure devices, but there is still doubt about which method is more suitable for the treatment of OSA in children.
Objective To analyze the effectiveness of MAAs in the treatment of pediatric OSA.
Materials and Methods The search was conducted in August 2021 in different electronic databases, such as PubMed, EBSCO (Dentistry & Oral Sciences Source), LILACS, Ovid, SciELO, Web of Science, EMBASE BIREME, BBO BIREME, and the Cochrane Library.
Results Only three systematic reviews and two meta-analyses were included in the present study. All studies showed improvement in the score on the apnea-hypopnea index after using MAAs in the treatment of pediatric OSA.
Conclusion Although more randomized studies are needed, based on the present umbrella review, MAAs must be considered part of the multidisciplinary treatment for pediatric OSA.
#
Introduction
Obstructive sleep apnea (OSA) is defined as intermittent partial or complete collapse of the upper airway during sleep.[1] It is a common condition in childhood, with an incidence ranging from 1.2% to 5.7%,[2] and it can harm several aspects of children's life, resulting in attention deficit, learning delay, memory consolidation impairment, aggressive behavior,[3] [4] metabolic disorders, cardiovascular disease, and nocturnal enuresis, for example.
Unlike the cases in adults, pediatric OSA is most related to adenotonsillar hypertrophy, which narrows the upper airway. Obesity is also among the main causes of pediatric OSA, but its complexity can also be explained by other factors, such as craniofacial type and neuromuscular tone.[5]
The choice of treatment for pediatric OSA considers age, severity of symptoms, clinical findings, presence of comorbidities and polysomnographic results.[6] Nowadays, there are many treatment options, such as adenotonsillectomy, myofunctional therapy, mandibular advancement appliances (MAAs), rapid maxillary expansion (RME), and positive airway pressure, but not all of them have the same efficacy and tolerance.
Adenotonsillectomy is still the most performed treatment in cases of pediatric OSA, and it has been highly effective throughout the years in non-obese children, even resulting in an improvement in oximetry results.[7] However, some studies[8] [9] [10] have reported that adenotonsillectomy is curative in 25% to 75% of the patients.
Continuous positive airway pressure (CPAP) is considered the first-line treatment in pediatric OSA without adenotonsillar hypertrophy, although with low tolerance (25% to 50%)[11] [12] [13] and risk of craniofacial sequels after long-term use.[14] [15] Myofunctional therapy helps tongue repositioning, improves nasal breathing, and increases muscle tone, preventing residual apnea after adenotonsillectomy and increasing CPAP adherence.[16]
Another therapeutic resource can be found in MAAs: mandibular advancement is well established in adult OSA treatment; in children, the aim is to correct mandibular retrognathia through redirection and stimulation of anterior mandibular growth, in a passive or active manner, which can be achieved through different appliances, such as the Herbst, Frankell II, twin-block, and others.[17]
Functional orthopedic appliances have been used to treat mandibular retrognathia in children and teenagers and, recently, to treat OSA. They are able to increase upper airway space, reduce airway collapsibility, and improve muscle tone.[18] [20] Thus one risk factor for adult OSA may have been solved.
The main goal of the present umbrella review was to analyze the effectiveness of MAAs in the treatment of pediatric OSA by means of apnea-hypopnea index (AHI) variability.
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Materials and Methods
The present umbrella review followed the checklist of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.
Inclusion Criteria
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- Population: children and adolescents (age ≤ 18 years) diagnosed with OSA without craniofacial syndromes.
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- Intervention: MAAs.
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- Comparison: with and without a control group.
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- Outcome: AHI.
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- Study design: systematic review and e meta-analysis.
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Search Strategy
A systematic search was conducted until August 2021 in the following electronic databases: PubMed, EBSCO (Dentistry & Oral Sciences Source), LILACS, Ovid, SciELO, Web of Science, EMBASE BIREME, BBO BIREME, and the Cochrane Library. The search terms were sleep apnea, obstructive, OSA, sleep disordered breathing, mandibular advancement, oral appliances, mandibular protractor, orthodontic treatment, children, and pediatric.
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Study Selection
Two reviewers (CCM and FRA) independently selected the articles, and only full-text articles were included.
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Data Collection
The following data were extracted from each study included: author, year of publication, study design, age of the sample, treatment, and AHI before and after MAAs.
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Risk of Bias in Individual Studies
To evaluate the risk of bias in individual studies, the University of Bristol's Risk of Bias in Systematic Reviews (ROBIS) tool was used. Two reviewers (CCM and FRA) independently evaluated the quality of the studies.
Both in terms of the criteria for the eligibility of studies and the methods, the articles included were considered to have low potential for bias. In the synthesis and results criterion, only one article was classified as presenting an unclear risk of bias. In the overall risk of bias assessment, the articles were classified as low risk, as they considered the heterogeneity of the data ([Table 1]).
Author/year |
Eligibility |
Identification and selection |
Data collection |
Synthesis and results |
Risk of bias |
---|---|---|---|---|---|
Yanyan et al., 2019[17] |
Y/Y/Y/Y/PY Low |
PY/NI/Y/Y/Y Low |
Y/PY/Y/Y/Y Low |
Y/Y/Y/PY/PN/PY Low |
Low |
Bariani et al., 2021[18] |
Y/PY/Y/Y/PY Low |
PY/NI/Y/Y/Y Low |
Y/Y/Y/NI/NI Low |
Y/N/PY/Y/PN/N Unclear |
Low |
Nazarali et al., 2015[19] |
Y/Y/Y/Y/PY Low |
PY/NI/Y/Y/Y Low |
Y/Y/PY/Y/PY Low |
Y/Y/PY/Y/PY/PY Low |
Low |
Carvalho et al., 2016[20] |
Y/Y/Y/Y/PY Low |
PY/NI/Y/PY/Y Low |
Y/Y/Y/Y/Y Low |
Y/Y/Y/Y/Y/Y Low |
Low |
Huynh et al., 2015[21] |
Y/Y/Y/Y/PY Low |
PS/S/S/S/S Low |
Y/PY/PY/Y/PY Low |
Y/Y/PY/Y/PY/Y Low |
Low |
Abbreviations: N. no; NI, no information; PN, probably no; PY, probably yes; ROBIS, Risk of Bias in Systematic Reviews; Y, yes.
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Results
The flow chart of the selection process is illustrated in [Figure 1]. A total of 36 articles were identified: 4 in EBSCO, 8 in PubMed, 8 in LILACS, 9 in EMBASE BIREME and BBO BOREME, 6 in the Cochrane Library, and 1 through other sources; 32 articles remained after duplicates were removed. Then, 27 articles were excluded after screening the titles, abstracts, study designs, and full text availability. Five articles remained: three systematic reviews and two meta-analyses.
![](https://www.thieme-connect.de/media/10.1055-s-00056804/202304/thumbnails/10-1055-s-0043-1776747-i938-1.jpg)
![Zoom Image](/products/assets/desktop/css/img/icon-figure-zoom.png)
The results of the present umbrella review are organized in [Table 2], followed by the studies included in each systematic review and meta-analysis, in [Table 3]. The selected articles were published between 2015 and 2021. The sample sizes ranged from 32 to 269 individuals aged between 3.5 and 14 years.
Study |
Study design |
Age |
Treatment duration |
ΔAHI |
AHI reduction (%) |
Conclusion |
---|---|---|---|---|---|---|
Yanyan et al., 2019[17] |
Meta- analysis |
No significant subgroup difference (I2= 0%; p = 0.59) |
Difference in treatment duration was observed: 3 weeks, 6 months, 10-12 months (I2= 65.9%; p = 0.05); long-term treatment (6 months, 10-12 months) may be more effective |
-1.75 events/h (95% confidence interval: -2.07–1.44; p = 0.00001) |
50% for mild (1.72/3.5), 57% for moderate (4.27/7.5), and 76% for severe (10.69/14.08) cases |
MAAs can be effective for mild to severe OSA before the end of pubertal peak; long-term treatment (of at least 6 months) may be more effective |
Bariani et al., 2021[18] |
Systematic review |
7.61 ± 1.99 years |
7.71 ± 5.13 months |
12 studies reported reduced AHI after treatment (could not be statistically analyzed due to the considerable heterogeneity of pooled data) |
Could not be statistically analyzed due to the considerable heterogeneity of pooled data |
FOA can be considered a potential additional treatment in children with OSA |
Nazarali et al., 2015[19] |
Systematic review |
8.71 ± 1.67 years |
9.6 ± 2.89 months |
Could not be statistically analyzed due to heterogeneity of pooled data |
≥ 50% (1 study used RDI) |
MAAs may improve AHI scores |
Carvalho et al., 2016[20] |
Systematic review |
7.1 ± 2.6 years |
6 months |
-4.5 events/h (p < 0.001) |
50% in 9 of the 14 subjects |
64.2% of success |
Huynh et al., 2015[21] |
Meta- analysis |
6.37 ± 1.72 years |
6 months |
-4.5 events/h; p < 0.001 (Villa et al.15); -4.22 events/h; p = 0.0003 (Cozza et al.32) |
≥ 50% |
MAAs can help in the management of pediatric snoring and OSA |
Abbreviations: AHI, apnea-hypopnea index; FOA, functional orthodontic appliance; MAAs, mandibular advancement appliances; OSA, obstructive sleep apnea; RDI, respiratory disturbance index.
Study |
Study design |
Subjects |
Age |
Interventions |
Wearing time |
Drop- out |
Outcomes |
---|---|---|---|---|---|---|---|
Villa et al. 2002[22] |
Randomized controlled trial |
MAAs: 19; control: 13 |
6.86 ± 2.34 years; 7.34 ± 3.10 years |
An acrylic plate; no treatment |
6 months (24h) – |
5 4 |
MAAs: AHI from 7.1 to 2.6; control: unchanged |
Nunes and Francesco-Mion, 2009[23] |
Randomized controlled trial |
MAAs: 24; control: 16 |
6-9 years |
Bioajusta X appliance; no treatment |
6 months – |
0 0 |
MAAs: improvements in breathing and snoring (questionnaire), airway space volumetric gain; control: airway space reduction |
Machado- Júnior et al., 2016[24] |
Randomized controlled trial |
MAAs: 8; control: 8 |
8.13 ± 0.99 years; 8.39 ± 1.31 years |
Two acrylic plates; no treatment |
12 months (24h) |
0 2 |
MAAs: AHI from 1.66 to 0.30; control: AHI from 1.58 to 1.97 |
Idris G. et al., 2018[25] |
Crossover- Randomized controlled trial |
MAAs: 9; control: 9 |
9.8 ± 1.1 years |
Twin-block; sham MAAs |
3 weeks overnight |
3 0 |
MAAs: AHI from 2.8 to 1.9; control: AHI from 2.4 to 3.7 |
Cozza et al., 2004[26] |
Non-randomized controlled trial (prospective) |
20 |
5.91 ± 1.14 years |
Modified monobloc |
6 months overnight |
0 |
AHI from 7.88 to 3.66 |
Schütz et al., 2011[27] |
Non-randomized controlled trial (prospective) |
16 |
12.6 years ± 11.5 months |
Herbst + RME |
12 months (24h) |
0 |
AHI from 4.8 to 1.3 and airway space improvement |
Zhang et al., 2013[28] |
Non-randomized controlled trial (prospective) |
46 |
9.7 ± 1.5 years |
Twin-block |
10.8 months (24h) |
0 |
AHI from 14.08 to 3.39 and airway space improvement |
Levrini et al., 2018[29] |
Non-randomized controlled trial (prospective) |
9 |
4-8 years |
Myobrace/MyOSA |
3 months |
0 |
AHI reduction was statistically significant (p = 0.0425) |
Maspero et al., 2015[30] |
Non-randomized controlled trial (prospective) |
MAAs: 40; control: 10 |
9-14 years; 9-14 years |
Andresen activator |
16 months |
0 |
AHI and airway space improvements |
Rădescu et al., 2017[31] |
Case report |
1 |
8 years |
Twin-block |
12 months |
0 |
AHI increased from 2.6 to 10.2 |
Rose and Schessl, 2006[32] |
Case report |
1girl and 1 boy |
8 years and 6.5 years |
Frankel II |
20 Months and 9 months |
0 |
Girl: AHI normalized; boy: less apnea and oxygen desaturation |
Schessl et al., 2006[33] |
Case report |
1 |
3.5 years |
Frankel II |
14 months |
0 |
RDI from 66 to 2 |
Modesti- Vedolin et al., 2018[25] |
Pilot study |
18 |
8.3 ± 2.3 years |
Thermoplastic intraoral device (superior and inferior) |
2 months |
0 |
RDI from 10 to 4.5 |
Abbreviations: AHI, apnea-hypopnea index; MAAs, mandibular advancement appliances; RDI, respiratory disturbance index; RME, rapid maxillary expansion.
Several types of MAAs were used, such as single acrylic plate, twin-block, two acrylic plates (Planas), Herbst + RME, Bioadjusta X, modified monoblock, Myobrace/MyOSA, Andresen activator, Frankel II, and a thermoplastic intraoral appliance.
In addition, different protocols regarding the period of use were established, ranging from 3 weeks to 20 months. In most studies, the MAAs treatment had a minimum duration of 6 months, with the exception of a subgroup treated for 3 weeks in the study by Yanyan et al.[17] Long-term treatment (6 to 12 months) was more effective than short-term treatment. In general, MAAs were well tolerated in the pediatric population, with only 14 treatment dropouts (6 controls and 8 patients treated with MAAs), in the included studies.
All studies presented a reduction in the AHI after treatment with MAAs, except those in the study by Rădescu et al.[31] In two studies,[18] [19] although there was a reduction in the AHI, it could not be statistically analyzed due to the considerable heterogeneity of the data. In the other 3 studies,[17] [20] [21] a reduction of at least 50% in the AHI was observed, which was considered as therapeutic success, even if the scores were not within the normal range.
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Discussion
In the last decade, several studies[19] [21] have reported that multidisciplinary (including orthodontic) treatments for pediatric OSA can really improve not only snoring, but also apnea through growth balance correction.
Mandibular advancement combined with RME is an alternative treatment method for pediatric patients with sleep respiratory disturbances.[17] [21]
In 1860, RME was reported for the first time as an orthodontic treatment for the correction of maxillary constriction. However, RME was linked to OSA treatment, since it was able to reduce, in children, nocturnal enuresis, a common OSA symptom. Nowadays, RME is often performed through a fixed intraoral orthodontic appliance, gradually adjusted throughout the treatment.[21]
According Yanyan et al.,[17] high-quality meta-analyses support mandibular advancement in OSA patients, even in severe cases, as long as the treatment is established before pubertal peak. Long-term treatment (of at least 6 months) is superior to the short-term treatment. Mandibular advancement appliances improve the AHI and increase posterior airway space, reducing airway collapsibility. From the orthodontic perspective, MAAs also promote dentoalveolar changes and bone growth.[17]
Several factors contribute to OSA occurrence, such as obesity and adenotonsillar hypertrophy, conditions that narrow the superior airway. Other conditions are abnormalities in craniofacial growth, such as atresic maxilla, mandibular retrognathia, increased vertical growth, and neuromuscular disorders.[18] [20]
A significant number of children do not respond to adenotonsillectomy, which is still the primary treatment for OSA, and most of them do not tolerate CPAP therapy. Therefore, functional orthopedic appliances, if correctly prescribed, are well tolerated and are able to increase airway space during sleep, reduce airway collapsibility, and improve muscle tone.[18] [20]
As the functional appliance brings the jaw forward, an increase in the superior airway space occurs. Therefore, the AHI will be improved, as long as the patient is wearing the appliance. Yet, if the etiology of the problem is retrognathia or maxillary constriction, skeletal and dentoalveolar correction must be achieved to complete correction of the malocclusion and stability of results.
If these changes are accomplished permanently, pediatric patients no longer need to wear the MAAS, since the skeletal growth is complete and this important OSA predisposing factor will be solved.[19]
Obstructive sleep apnea is related to many diseases and social problems. Many adults begin snoring and experiencing other respiratory disturbances, such as OSA, in childhood; hence, the relevance of early diagnosis and treatment to prevent long-term complications in adult life. These measures also contribute to reduce costs to the healthcare system and improve quality of life.[20]
The diagnosis of OSA is based on anamnesis, physical examination, and laboratory tests, and, to date, polysomnography is the gold-standard examination. Although adenotonsillectomy is widely performed to treat pediatric OSA around the world, recurrence is very common, particularly in children with skeletal deformities, such as mandibular retrognathia, maxillary constriction, or both.[20]
All studies included in the present review showed AHI reduction, except for Rădescu et al.,[31] who observed an AHI increase. An early orthodontic treatment with a functional appliance appeared to be an accurate device to correct the molar relationship and reduce overjet in children with retrognathic mandible, but, in this study,[31] the results were lower than expected, and the authors highlighted that pharyngeal surgery should be considered after anti-inflammatory therapies, and consultation with an otolaryngologist should be mandatory before the orthodontic treatment.[31] Nevertheless, we should emphasize that Rădescu et al.,[31] report a single case in their study.
Studies[17] [18] [19] [20] [21] were carried out with children who had not undergone adenotonsillar surgery. Zhang et al.[28] and Rose and Schessl[32] excluded children with adenotonsillar hypertrophy. Modesti-Vedolin et al,[34] treated children in the Otolaryngology Service who were in the waiting list for amygdalectomy, and they observed a reduction in the respiratory disturbance index from 10 to 4.5/h. Villa et al[22] included children with adenotonsillar hypertrophy and they still observed an improvement in the AHI, from 7.1 to 2.6/h, as well as a reduction in adenotonsillar hypertrophy after 6 months.[22]
Pediatric OSA often has a multifactorial etiology, which could justify cases of residual apnea in patients only submitted to one treatment modality, such as adenotonsillectomy. Nowadays, there are many treatment options, such as myofunctional therapy, adenotonsillectomy, CPAP, MAAs, and/or RME.
To establish an adequate treatment plan for pediatric OSA, the factors involved in airway obstruction must be identified, such as obesity, adenotonsillar hypertrophy, facial skeleton abnormalities etc.[35] According to what is found, it may be necessary to combine therapies to achieve cure.
Mandibular advancement appliances are well tolerated, even in treatments longer than 6 months, according to the results of previous studies.[28] [30] The Herbst appliance, for example, has intermaxillary anchorage; therefore, as it advances the mandible, it causes a contrary reaction of equal intensity in the upper dental arch. Since it is partially fixed to the teeth, it can work 24 hours a day and eliminate the chances of poor adherence to treatment. The two acrylic plates (Planas) consist of indirect tracks supported by metallic arches joining the upper and lower parts, which ensures the preservation of mandibular posture.
On the other hand, the twin-block consists of two (upper and lower) bite blocks with inclined planes, which are designed to fit together so that the mandible adopts an anterior position. The Frankel II appliance, unlike the Andresen activator, was not designed to move teeth by exerting pressure, but by controlling muscle pressures, thus inducing therapeutic changes.
Some possible side-effects related to the MAAs are more likely to happen in patients with Angle class-I and III malocclusion, because the mandibular advancement can lead class-I patients to class III, and, in the condition of class-III patients can be worsened by the mandibular advancement.[36] Mandibular advancement appliances may cause posterior dental disocclusion, orofacial and temporomandibular joint pain, and tooth breakage during mastication. All these undesirable effects are most common in the long-term treatment (of at least 5 years),[36] which exceeds the treatment period of the studies included in the present umbrella review.
Another aspect that should be considered is that MAAs may decrease the intraoral space for the tongue, which can be displaced backwards, leading to a collapse of the tongue base. Machado-Júnior et al.,[24] for example, took this aspect into account in their study, so their appliance, despite being based on the Planas device, was modified to minimize this possible undesirable effect. Occlusion between the plates and, consequently, mandibular advancement was achieved by means of two tracks built on the occlusal part of the apparatus, not on the lingual part, as recommended by Planas. Union between the two upper half arches was achieved not by means of an expansion screw as recommended by Planas, but by means of a Cofen spring.[24]
As a rule, functional orthopedics aims to guide the natural growth of the craniofacial skeleton, using the devices as translators of the forces of the muscles against the basal bones and the alveolar process.
The herein data obtained show that MAAs are a viable and complementary therapeutic resource for the treatment of OSA in children and adolescents with craniofacial disorders, such as those with Angle class-II malocclusion, maxillary narrowing, and mandibular retrognathia, which are very frequent alterations in mouth breathers. This emphasizes the importance of multidisciplinary treatment involving Otorhinolaryngology and Dentistry.
Although none of the studies included reported a cure for OSA (AHI < 1 event/h) after the use of MAAS, the reduction of at least 50% in respiratory events in children who had not undergone adenotonsillar surgery, associated with adherence, shows its effectiveness. However, the few studies analyzed had small samples, except for the one by Bariani et al.,[18] in which the sample was larger, but the statistical analysis was not possible due to the heterogeneity of the data. Therefore, the results must be analyzed carefully. This is a relatively new field within sleep medicine, with many questions to be explained.
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Conclusion
Although more randomized studies are needed, based on the present umbrella review, MAAs must be considered part of a multidisciplinary treatment for children with OSA.
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Highlights
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Pediatric OSA often has a multifactorial etiology.
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It may be necessary to combine therapies to achieve cure.
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Mandibular advancement appliances are well tolerated and result in a reduction of at least 50% in respiratory events.
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Long-term treatment (from 6 to 12 months) is more effective.
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There is a lack of statistically significant data in this field.
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Conflict of Interests
The authors have no conflict of interests to declare.
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- 25 Idris G, Galland B, Robertson CJ, Gray A, Farella M. Mandibular advancement appliances for sleep-disordered breathing in children: A randomized crossover clinical trial. J Dent 2018; Apr; 71: 9-17 DOI: 10.1016/j.jdent.2018.01.006. . Epub 2018 Jan 31. PMID: 29357293
- 26 Cozza P, Polimeni A, Ballanti F. A modified monoblock for the treatment of obstructive sleep apnoea in paediatric patients. Eur J Orthod 2004; Oct; 26 (05) 523-530 DOI: 10.1093/ejo/26.5.523. . PMID: 15536841
- 27 Schütz TC, Dominguez GC, Hallinan MP, Cunha TC, Tufik S. Class II correction improves nocturnal breathing in adolescents. Angle Orthod 2011; Mar; 81 (02) 222-228 DOI: 10.2319/052710-233.1. . PMID: 21208073
- 28 Zhang C, He H, Ngan P. Effects of twin block appliance on obstructive sleep apnea in children: a preliminary study. Sleep Breath 2013; Dec; 17 (04) 1309-1314 DOI: 10.1007/s11325-013-0840-5. . Epub 2013 Apr 6. PMID: 23558604
- 29 Levrini L, Salone GS, Ramirez-Yanez GO. Efficacy of a Pre-Fabricated Myofunctional Appliance for the Treatment of Mild to Moderate Pediatric Obstructive Sleep Apnea: A Preliminary Report. J Clin Pediatr Dent 2018; 42 (06) 475-477 DOI: 10.17796/1053-4625-42.6.14. . Epub 2018 Aug 7. PMID: 30085867
- 30 Maspero C, Giannini L, Galbiati G, Kairyte L, Farronato G. Upper airway obstruction in class II patients. Effects of Andresen activator on the anatomy of pharyngeal airway passage. Cone beam evaluation. Stomatologija 2015; 17 (04) 124-130 . PMID: 27189498
- 31 Rãdescu OD, Albu S, Baciut M, Bran S, Coman AC, Bechir ES. et al. Results in the treatment with twin block polymeric appliance of the retrognathic mandible in sleep apnea patients. Rev Mater Plast 2017; 54: 473-476
- 32 Rose E, Schessl J. Orthodontic procedures in the treatment of obstructive sleep apnea in children. J Orofac Orthop 2006; Jan; 67 (01) 58-67 . English, German. DOI: 10.1007/s00056-006-0534-8. . PMID: 16447025
- 33 Schessl J, Rose E, Korinthenberg R, Henschen M. Severe obstructive sleep apnea alleviated by oral appliance in a three-year-old boy. Respiration 2008; 76 (01) 112-116 DOI: 10.1159/000098407. . Epub 2007 Jan 5. PMID: 17202808
- 34 Modesti-Vedolin G, Chies C, Chaves-Fagondes S, Piza-Pelizzer E, Lima-Grossi M. Efficacy of a mandibular advancement intraoral appliance (MOA) for the treatment of obstructive sleep apnea syndrome (OSAS) in pediatric patients: A pilot-study. Med Oral Patol Oral Cir Bucal 2018; Nov 1; 23 (06) e656-e663 DOI: 10.4317/medoral.22580. . PMID: 30341264; PMCID: PMC6260994
- 35 Kaditis A, Kheirandish-Gozal L, Gozal D. Algorithm for the diagnosis and treatment of pediatric OSA: a proposal of two pediatric sleep centers Sleep Med 2012; Mar; 13 (03) 217-227 DOI: 10.1016/j.sleep.2011.09.009. . Epub 2012 Feb 1. PMID: 22300748
- 36 Karadeniz C, Lee KWC, Lindsay D, Karadeniz EI, Flores-Mir C. Oral appliance -generated malocclusion traits during the long-term management of obstructive sleep apnea in adults: A systematic review and meta- analysis. 316.1
Address for correspondence
Publication History
Received: 16 May 2022
Accepted: 31 January 2023
Article published online:
22 November 2023
© 2023. Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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- 25 Idris G, Galland B, Robertson CJ, Gray A, Farella M. Mandibular advancement appliances for sleep-disordered breathing in children: A randomized crossover clinical trial. J Dent 2018; Apr; 71: 9-17 DOI: 10.1016/j.jdent.2018.01.006. . Epub 2018 Jan 31. PMID: 29357293
- 26 Cozza P, Polimeni A, Ballanti F. A modified monoblock for the treatment of obstructive sleep apnoea in paediatric patients. Eur J Orthod 2004; Oct; 26 (05) 523-530 DOI: 10.1093/ejo/26.5.523. . PMID: 15536841
- 27 Schütz TC, Dominguez GC, Hallinan MP, Cunha TC, Tufik S. Class II correction improves nocturnal breathing in adolescents. Angle Orthod 2011; Mar; 81 (02) 222-228 DOI: 10.2319/052710-233.1. . PMID: 21208073
- 28 Zhang C, He H, Ngan P. Effects of twin block appliance on obstructive sleep apnea in children: a preliminary study. Sleep Breath 2013; Dec; 17 (04) 1309-1314 DOI: 10.1007/s11325-013-0840-5. . Epub 2013 Apr 6. PMID: 23558604
- 29 Levrini L, Salone GS, Ramirez-Yanez GO. Efficacy of a Pre-Fabricated Myofunctional Appliance for the Treatment of Mild to Moderate Pediatric Obstructive Sleep Apnea: A Preliminary Report. J Clin Pediatr Dent 2018; 42 (06) 475-477 DOI: 10.17796/1053-4625-42.6.14. . Epub 2018 Aug 7. PMID: 30085867
- 30 Maspero C, Giannini L, Galbiati G, Kairyte L, Farronato G. Upper airway obstruction in class II patients. Effects of Andresen activator on the anatomy of pharyngeal airway passage. Cone beam evaluation. Stomatologija 2015; 17 (04) 124-130 . PMID: 27189498
- 31 Rãdescu OD, Albu S, Baciut M, Bran S, Coman AC, Bechir ES. et al. Results in the treatment with twin block polymeric appliance of the retrognathic mandible in sleep apnea patients. Rev Mater Plast 2017; 54: 473-476
- 32 Rose E, Schessl J. Orthodontic procedures in the treatment of obstructive sleep apnea in children. J Orofac Orthop 2006; Jan; 67 (01) 58-67 . English, German. DOI: 10.1007/s00056-006-0534-8. . PMID: 16447025
- 33 Schessl J, Rose E, Korinthenberg R, Henschen M. Severe obstructive sleep apnea alleviated by oral appliance in a three-year-old boy. Respiration 2008; 76 (01) 112-116 DOI: 10.1159/000098407. . Epub 2007 Jan 5. PMID: 17202808
- 34 Modesti-Vedolin G, Chies C, Chaves-Fagondes S, Piza-Pelizzer E, Lima-Grossi M. Efficacy of a mandibular advancement intraoral appliance (MOA) for the treatment of obstructive sleep apnea syndrome (OSAS) in pediatric patients: A pilot-study. Med Oral Patol Oral Cir Bucal 2018; Nov 1; 23 (06) e656-e663 DOI: 10.4317/medoral.22580. . PMID: 30341264; PMCID: PMC6260994
- 35 Kaditis A, Kheirandish-Gozal L, Gozal D. Algorithm for the diagnosis and treatment of pediatric OSA: a proposal of two pediatric sleep centers Sleep Med 2012; Mar; 13 (03) 217-227 DOI: 10.1016/j.sleep.2011.09.009. . Epub 2012 Feb 1. PMID: 22300748
- 36 Karadeniz C, Lee KWC, Lindsay D, Karadeniz EI, Flores-Mir C. Oral appliance -generated malocclusion traits during the long-term management of obstructive sleep apnea in adults: A systematic review and meta- analysis. 316.1
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