Use of Mexiletine in Children: A Minireview

Catherine Sarret; Sarah Barrière; Ganaelle Remerand; Grégoire Massoullie; Aurélie Chalard; Claire Dauphin; Bénédicte Pontier; Fanny Laffargue

doi:10.1055/s-0043-1778102

Journal of Pediatric Neurology, Inhaltsverzeichnis

Journal of Pediatric Neurology 2024; 22(06): 425-428
DOI: 10.1055/s-0043-1778102

Review Article

Use of Mexiletine in Children: A Minireview

Catherine Sarret

¹Centre de Référence Maladies Rares des Pathologies Neuromusculaires, Service de Génétique Médicale, CHU Clermont-Ferrand, Clermont-Ferrand, France

,

Sarah Barrière

¹Centre de Référence Maladies Rares des Pathologies Neuromusculaires, Service de Génétique Médicale, CHU Clermont-Ferrand, Clermont-Ferrand, France

²Centre de Compétence Maladies Rares des Epilepsies, Service de Pédiatrie et Service de Néonatalogie, CHU Clermont-Ferrand, Clermont-Ferrand, France

,

Ganaelle Remerand

²Centre de Compétence Maladies Rares des Epilepsies, Service de Pédiatrie et Service de Néonatalogie, CHU Clermont-Ferrand, Clermont-Ferrand, France

,

Grégoire Massoullie

³Centre de Compétence Maladies Rares des Malformations Cardiaques Complexes, Service de Cardiologie, CHU Clermont-Ferrand, Clermont-Ferrand, France

,

Aurélie Chalard

³Centre de Compétence Maladies Rares des Malformations Cardiaques Complexes, Service de Cardiologie, CHU Clermont-Ferrand, Clermont-Ferrand, France

,

Claire Dauphin

³Centre de Compétence Maladies Rares des Malformations Cardiaques Complexes, Service de Cardiologie, CHU Clermont-Ferrand, Clermont-Ferrand, France

,

Bénédicte Pontier

¹Centre de Référence Maladies Rares des Pathologies Neuromusculaires, Service de Génétique Médicale, CHU Clermont-Ferrand, Clermont-Ferrand, France

,

Fanny Laffargue

¹Centre de Référence Maladies Rares des Pathologies Neuromusculaires, Service de Génétique Médicale, CHU Clermont-Ferrand, Clermont-Ferrand, France

› Institutsangaben

Abstract

Mexiletine is well-established sodium channel blocker that acts on cardiac myocytes and neurons. It has recently been repositioned as an orphan drug in the treatment of rare neuromuscular diseases in adults with nondystrophic myotonia. It has also long been used in some rare pediatric diseases in the areas of cardiopathy, epilepsy, neuromuscular diseases, and pain disorders. Here, we review the different uses of mexiletine reported in pediatrics, stating indications, efficacy, and tolerance. Special attention by health authorities to maintain access to mexiletine in rare pediatric diseases and further pediatric research in these rare syndromes are required.

Keywords

mexiletine - children - long QT syndrome - nondystrophic myotonia - myotonic dystrophy - erythromelalgia - epilepsy

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Referenzen

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