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Neuropediatrics 2024; 55(06): 356-365
DOI: 10.1055/s-0044-1788661
Original Article

Comparative Analysis of Supratentorial Intraventricular Tumors in Adults and Pediatrics in a Developing Country: Clinicopathological Features, Surgical Management, and Outcomes

Sandeep Mishra
1   Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India
2   Department of Neurosurgery and Neurointervention, Neo Multispeciality Hospital, Noida, Uttar Pradesh, India
,
Saurav Mishra
3   Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India
,
Sabina Regmi 
4   Department of Anaesthesia and Intensive Care, Neo Multispeciality Hospital, Noida, Uttar Pradesh, India
,
Varidh Katiyar
1   Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India
,
Satish Verma
1   Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India
,
Guru Dutt Satyarthee
1   Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India
,
Kanwaljeet Garg
1   Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India
,
Shashwat Mishra
1   Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India
,
M.C. Sharma
5   Department of Neuropathology, All India Institute of Medical Sciences, New Delhi, India
,
ManMohan Singh
1   Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India
,
Shashank Sharad Kale
1   Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India
› Institutsangaben Funding Support was provided solely from institutional and departmental sources.
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Abstract

Background Supratentorial intraventricular tumors, encompassing lateral and third ventricular tumors, are uncommon intracranial neoplasms, typically slow-growing and benign, manifesting symptoms only upon reaching a substantial size. This study aims to identify optimal surgical approaches, assess the prevalence and characteristics of these tumors, and evaluate postoperative outcomes among pediatric and adult age groups.

Methods A retrospective comparative study at a tertiary care hospital from January 2014 to June 2020 included 165 patients (68 pediatrics, 97 adults) meeting inclusion criteria for intraventricular tumor management. Data covered demographic factors, clinical history, neurological assessments, neuroimaging, surgical approaches, histopathological diagnoses, immunohistochemical features, adjuvant therapies, follow-up status, postoperative complications, and morbidity/mortality.

Results Ventricular tumor incidence showed male preponderance in both adults (M:F = 1.2:1) and pediatrics (M:F = 3:1). Lateral ventricles were the most common location. Pediatric cases exhibited more frequent calcifications on computed tomography scans (35.6% vs. 29.5%). Grade II and III tumors were more prevalent in adults within the lateral ventricle (27.1 and 1.9%) compared with pediatrics (6.5 and 8.4%). The third ventricle predominantly featured benign lesions, with pediatric patients experiencing significantly longer hospital stays (16.12 ± 21.94 days vs. 9.58 ± 6.21 days) (p = 0.006). Adults and pediatric patients showed a significant difference in high-grade lateral ventricle tumors (p-value = 0.002[*]).

Conclusions Supratentorial ventricular tumors are relatively more prevalent in children than adults, presenting challenges due to size and bleeding risks. Surgical resection is the primary treatment, with a focus on the optimal approach for gross total excision to reduce recurrence risk.

Keywords

ventricular tumors - pediatrics - care - patients - outcomes

The study was performed at All India Institute of Medical Sciences, New Delhi, India.


The significance of the footnote “*” is that it denotes statistically significant value.




Publikationsverlauf

Eingereicht: 10. Mai 2024

Angenommen: 02. Juli 2024

Artikel online veröffentlicht:
29. Juli 2024

© 2024. Thieme. All rights reserved.

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