Immunoglobulin D-Lambda Multiple Myeloma Initially Presenting in the Sphenoid Sinus, Orbital Apex, and Skull Base: A Systematic Review with a Case Report

Abstract

Objectives Multiple myeloma (MM) with initial manifestations in the sphenoid sinus, orbital apex, and skull base is exceedingly rare. A systematic review was conducted to investigate the epidemiology and advancements.

Methods Relevant cases were identified by searching CNKI, WanFang Data, CQVIP databases, PubMed, Embase, and Web of Science. Additionally, we present a case of IgD-λ (immunoglobulin D-lambda) MM with initial symptoms of dizziness, unilateral pain, blindness, and ophthalmoplegia, leading to a 4-month overall survival. Strictly based on PRISMA standards, we included and summarized existing cases and reflected our case.

Results Our systematic review includes 34 case reports, revealing 67.6% of patients initially presented with diplopia and 44.1% underwent endoscopic procedures, notably with only two cases of IgD-λ subtype. In our case, we performed an endoscopic wide trans-ethmoidal sphenoidotomy and biopsy of the skull base and orbital apex lesion. Postoperative pathology confirmed a highly active plasmacytoma, clinically diagnosed as IgD-λ MM with a TP53 deletion mutation and multiple extramedullary metastases. A range of diagnostic tools was employed, including hemoglobin, immunoglobulin, urinary protein analysis, positron emission tomography-computed tomography (CT), bone marrow cytology, and gene detection.

Conclusion The subtle clinical manifestations of IgD-λ MM in the paranasal sinuses and skull base hinder early diagnosis. There is a paucity of literature describing MM initially presenting in these locations. CT/magnetic resonance scans are necessary to identify characteristic bone destruction. An endoscopic approach is popular for tissue biopsy. Bone marrow biopsy with a smear, serum or urine protein electrophoresis, and immunofixation electrophoresis are crucial upon the appearance of target organ damage.

Keywords

case report - extramedullary metastasis - multiple myeloma - sphenoid sinus - skull base

Introduction

Multiple myeloma (MM) is a hematological malignancy characterized by the uncontrolled proliferation of plasma cells within the bone marrow, leading to the production of monoclonal immunoglobulins (M proteins).[1] Immunoglobulin D-lambda (IgD-λ)-type MM exhibiting extramedullary involvement in the orbital apex, sphenoid sinus, and ethmoid sinus represents an exceptionally rare variant. The clinical symptoms and imaging manifestations associated with such cases are often nonspecific, which poses challenges that increase the likelihood of misdiagnosis or delayed diagnosis, and subsequently impact prognosis.[2] In recognition of the critical need for a more comprehensive understanding of this rare and diagnostically challenging subset of MM, we conducted a scoping review to enhance awareness, improve early diagnostic rates, and facilitate timely treatment. Additionally, we present a distinctive case of IgD-λ MM characterized by an initial presentation in the orbital apex, sphenoid sinus, and ethmoid sinus. This case serves to illustrate the complexities associated with this variant and emphasizes the importance of heightened clinical suspicion and accurate diagnostic approaches to achieve optimal patient outcomes.

Materials and Methods

Search Strategy

Our comprehensive research involved an exhaustive search across multiple databases, including CNKI, WanFang Data, CQVIP, PubMed, Embase, and Web of Science, extending up to August 31, 2023. The search strategy employed a combination of subject terms and free-text keywords, such as “multiple myeloma,” “paranasal sinuses,” “skull base,” “plasma-cell myeloma,” “Kahler disease,” “nasal sinuses,” “ethmoid sinus,” and “sphenoid sinus.” A detailed retrieval strategy can be accessed in [Supplementary Table S1] (available in online version only).

Inclusion and Exclusion Criteria

Inclusion criteria: the following criteria were used to select articles for consideration:

• Case reports subsequent to January 1, 1980, and were available in Chinese or English.

• Cases in which MM initially manifested in the nasal sinuses and skull base, with a clear diagnosis based on the Multiple Myeloma Guidelines (2021) of the National Comprehensive Cancer Network (NCCN)[3] and the Guidelines for the Diagnosis and Management of Multiple Myeloma in China (2022 revision).[4] There were no gender or age restrictions.

Exclusion criteria: articles were excluded if they met any of the following criteria:

• Cases lacking an explicit diagnostic basis, those with a previous history of MM, or individuals who developed tumor lesions in other sites, experienced recurrence, or metastasis several months after the diagnosis of solitary extramedullary plasmacytoma, or with central nervous system involvement without lesions in the nasal sinuses or skull base were excluded.

• The absence of sufficient details in the description of at least four essential data points.

• Duplicate publications, studies lacking relevant data, or those inaccessible to researchers.

Data Extraction

Data extraction encompassed the following elements:

• Basic study information: this category includes the study's title, Study ID, and other pertinent details.

• Case report details: this section systematically captured essential information on each case, encompassing details related to age, gender, chief complaints, lesion locations, surgical interventions, diagnosis criteria, MM subtype, treatment modalities, follow-up data, and prognosis.

Results

Systematic Scoping Review

A total of 526 records were initially retrieved and imported into NoteExpress 3.2.0. Following the removal of duplicate records, 492 unique articles remained. The researchers conducted an initial screening based on titles and abstracts, narrowing down the selection to 288 records. Subsequently, a thorough review of full-text articles led to the inclusion of 34 articles. The search process is presented in a visual summary in accordance with PRISMA guidelines ([Fig. 1]). The final selection comprised 34 cases of MM patients who initially presented with lesions in the nasal sinuses and skull base. The male-to-female ratio was 19:15 among these cases. The majority of patients (67.6%) exhibited symptoms indicative of optic nerve, chiasma, or optic tract compression, such as diplopia, abnormal vision, or visual field disturbances at their initial presentation.

Fig. 1 Search process depicted by the PRISMA flowchart.

Surgical intervention was performed in 29 cases (85.3%), with 15 patients (44.1%) explicitly opting for endoscopic surgical approaches. The primary diagnostic methods employed included tissue biopsy, bone marrow examination, and serum/urine protein electrophoresis. The majority of patients underwent a combination of systemic chemotherapy and local radiotherapy, while a small number underwent autologous stem cell transplantation (ASCT).

Of the reported cases, 26 (76.5%) specified the MM subtype. It is noteworthy that only two cases (7.4%) involved IgD-λ-type MM, with one of these cases being female. Both IgD-λ patients succumbed within 12 months of diagnosis.

For a detailed account of the characteristics of the included cases, please refer to [Table 1].

Table 1 Basic characteristics of included cases

Study ID (first author, year)	Age	Sex	Chief complaint	Lesion sites	Surgical intervention	Diagnostic basis	Subtype	Treatment	Follow-up (mo)	Prognosis
Liu 2013[48]	26	M	Bilateral ear stuffy, diplopia, headache, progressive numbness of both lower limbs	Mass in sphenoid sinus, abnormal signal in cervical medullary, and cavernous sinus	Endoscopic biopsy	1, 3	–	Chemotherapy (V)	7	Death
Shah, 2023[49]	68	M	Progressive blurred vision, periorbital pain, frontal headache, intermittent back pain	Centered in slope, extended to pituitary fossa, entered bilateral sphenoid sinus, and ethmoid sinus	–	2, 4	–	Chemotherapy (VCD)	3 wk	Alleviate
Zuo, 2002[50]	44	M	Hoarseness, diplopia	Sphenoid and sella, bottom of sella, ethmoidal sinus	Biopsy	1, 3	–	Chemotherapy (M2), Intracranial radiotherapy	7	Improve
Wu, 2006[78]	57	M	Frontal headache, nausea	Posterior cranial fossa, straddling transverse sinus, skull base fracture	Open procedure excision	1, 3	IgG-λ	Chemotherapy	3	Stable
Qu, 2018[51]	61	M	Unilateral decreased vision	Left sphenoid sinus occupied with adjacent bone infiltration	Biopsy	1, 3, 5, 6	λ	Chemotherapy (BD-PACE), Allo-SCT intended	–	Improve
Chen, 2003[80]	48	M	Bilateral decreased vision, bone pain, dizziness, headache	Sella-slope occupation with skull base fracture	Endoscopic biopsy and excision	1, 3, 4	IgG-λ	Chemotherapy (VAD)	1	Improve
Lu, 2009[79]	62	F	Headache, unilateral double vision	Sellar region, occipital slope, with bone destruction	–	3, 4, 5	Light chain	Chemotherapy (TD)	5d	Improve
Johnson, 2022[52]	52	M	Persistent visual changes, headache, epistaxis, fatigue	Invaded the cavernous sinus, displaced the internal carotid artery, extending to the middle cranial fossa, sphenoid sinus, posterior ethmoidal air chamber and slope, anterior pontine cisterna	Endoscopic biopsy and partial excision	1, 3, 6, 7	–	Local radiotherapy, Palliative radiotherapy, Chemotherapy (CyBorD, VRD), ASCT intended	–	VGPR
Silverman, 2022[53]	60	M	Intermittent diplopia, pain above the left eye, progressive ptosis	Left slope mass with cavernous sinus and slope extension with bone erosion	Endoscopic biopsy	1, 2, 4	IgG-λ	Pulse steroid + dexamethasone, local radiotherapy, Bortezomib intended	5	Death
Joshi, 2011[54]	66	M	Intermittent imbalance, right ear discomfort with hearing loss, dizziness, diplopia, right occipital headache, facial numbness	Mass located at the right apex of rock, destroyed the condyle of the right occipital bone, right side of the slope, body of the sphenoid bone, cavernous sinus, and apex of rock	–	3, 4	λ	Radiotherapy, cyclophosphamide, chemotherapy (VAD)	–	Alleviate
Ustuner, 2003[55]	39	M	Progressive paresthesia on the left side of the face and left arm, intermittent diplopia, dysphagia, hoarseness	Mass extends from the ethmoid and sphenoid sinuses to the junction of the slope and petroclival	Endoscopic biopsy	1, 2	Light chain	Local radiotherapy, chemotherapy (VAD), ASCT intended	–	Stable
Hogan, 2002[56]	39	M	Progressive loss of vision to amaurosis in the right eye, numbness in the left mandible, low fever, fatigue, frontal headache	Single epidural lesion of right orbital apex and sphenoid sinus near anterior bed process, optic nerve compression	–	2, 3	IgA-λ	Chemotherapy (VAD), radiotherapy, Allo-BMT	24	Improve
Yamguchi, 2008[57]	65	F	Progressive diplopia	Mass invaded sinuses, slopes, rock apex and infratemporal fossa, slopes and sphenoid bone	Endoscopic biopsy and radical excision	1, 3, 4	IgA-λ	Local radiotherapy, chemotherapy (VAD), ASCT, thalidomide	17	Stable
Wein, 2002[58]	60	F	Left frontal headache, dacryorrhea with bulbar conjunctival edema	Invasive mass in the left supraorbital region involving the frontal and ethmoid sinuses	Biopsy	1, 2	–	Chemotherapy (VAD)	–	Alleviate
Wachter, 2010[19]	43	F	Acute unilateral vision loss	Mass in the left optic channel, wrapped optic nerve, calcification around the mass, sphenoid sinus, and cavernous sinus	Open procedure excision	1	λ	Local radiotherapy, intrathecal methotrexate, ASCT intended	12	Progress
Alegre, 1996[59]	40	F	Sudden diplopia and dysarthria	Enlarged basal bone tumor of the skull, destroyed the left petroclival region and extended to sphenoid sinus	Biopsy and partial excision	1, 3	–	Local radiotherapy, chemotherapy (VAD), PBSCT	18	CR
Kadiri, 2016[60]	56	F	Temporary headache, diplopia	Sphenoid sinus mass invades the sphenoid bone and extends to the left temporal region and cavernous sinus	Endoscopic biopsy	1, 2, 4	IgA-κ	Chemotherapy (dexamethasone + zoledronic acid), decompression radiotherapy	8	Death
Humphrey, 1983[61]	60	M	Left sixth nerve paralysis, left shoulder pain	Sphenoid sinus	Biopsy	1, 4	IgD-λ	Local radiotherapy, chemotherapy (M2)	12	Death
Hess, 2006[62]	58	M	Pain and swelling in the right jaw	Sphenoid sinus mass invaded nasopharynx	Biopsy	1	Light chain	Chemotherapy, radiotherapy, ASCT	–	Alleviate
Liu, 2023[63]	54	F	Dizziness, loss of right visual field with nausea and vomiting	Soft tissue mass in sphenoid sinus invaded occipital bone	–	3, 5, 6	IgD-λ	Chemotherapy (VCD, DVD-R, PLD, DEDP-R)	9	Death
Yazdanpanah, 2020[64]	45	M	Diplopia, headache, cough, and difficulty breathing	Involved sphenoid sinus and slopes, extending to the anterior pontine cistus and bilateral cavernous sinuses (left > right)	Endoscopic biopsy and excision	2, 4, 6	IgG-λ	Local radiotherapy, Chemotherapy (E-KRd)	–	Alleviate
Movsas, 2000[65]	78	F	Bilateral horizontal diplopia, headache, lameness in lower limbs	Slope mass, right cavernous sinus involvement, extending into sphenoid sinus, with bone destruction	Endoscopic biopsy	1, 2, 4, 5	IgG-κ	Local radiotherapy, chemotherapy (MP)	–	–
Bachmeyer, 1997[66]	77	M	Temporary loss of consciousness, intermittent horizontal diplopia	Invaded entire sphenoid sinus and destroyed sphenoid bone, extending to the ethmoid sinus, slope	Biopsy	1, 2, 3	IgG-λ	Radiotherapy, chemotherapy (MP)	6	Stable
Oushy, 2018[67]	59	F	Ear distension, postural vertigo, pulsing tenderness in left ear, hoarseness, dysphagia	Internal lesion of left jugular foramen, tumor of left posterior occipital bone	Open procedure stereotactic biopsy	1, 2, 4	κ	Chemotherapy (VRd), ASCT	–	–
Reddy, 2021[68]	52	M	Unilateral diplopia, headache, sticky purulent discharge in the right ear, hearing impairment	Slope mass invaded the left cavernous sinus, multiple osteolytic lesions of the skull	Endoscopic biopsy	1, 2, 4	κ	Chemotherapy (VCD), local palliative radiotherapy	–	Alleviate
Patel, 2010[69]	42	F	Occipital headache, nausea, vomiting	Posterior fossa mass, osteolytic destruction of occipital bone, compression of Sylvius aqueduct and fourth ventricle, with hydrocephalus	Open procedure	1, 2, 4	IgG-λ	Steroid, cytotoxicity, radiotherapy	–	–
Rahman, 2016[70]	84	F	Headache, blurred vision, progressive bilateral horizontal diplopia	Slope mass extends to the sphenoid and posterior ethmoid sinuses	Endoscopic biopsy	1, 2	λ	Radiotherapy, chemotherapy (V)	–	–
How, 2019[71]	29	F	Distension, hearing loss, unilateral pulsating tinnitus, loss of taste	Central mass of the right jugular foramen with extensive bone destruction and an erosive appearance	Open procedure biopsy and excision	1, 2, 4, 6, 7	IgA-κ	Dexamethasone + local palliative radiotherapy, chemotherapy (KRd)	–	Alleviate
Magrassi, 2016[72]	57	M	Sudden diplopia, dizziness	Osteolytic clival disease extending to both the great wings of the sphenoid bone and the right petrous bone, with partial involvement of the inner ear	Stereotactic biopsy	1, 2	IgG-κ	Radiotherapy, chemotherapy	–	–
Du, 2015[77]	47	F	Frontal headache, eye distention	Mass in the sphenoid sinus, partial fracture of the sinus wall	Endoscopic biopsy	1, 3, 4	IgG	Chemotherapy	–	Alleviate
Shenoy, 2010[73]	58	M	Left side hearing loss, dizziness, headache	Slope mass invaded rock apex, left jugular bulb, and left cerebellar cornual cisterna extending to left sigmoid sinus	Endoscopic biopsy	1, 3, 4	–	Chemotherapy (TD), local radiotherapy, BMT	–	–
Rezazadeh, 2005[74]	62	M	Progressive cervical pain and diplopia	Slope mass extends to the brain stem, left inner ear and internal carotid artery canals, nasopharynx, sphenoid bone, cavernous sinus	Endoscopic stereotactic biopsy	1, 3, 4, 5	κ	Dexamethasone, radiotherapy	–	–
Higurashi, 2004[75]	53	F	Diplopia, left abducent paralysis	Osteolytic mass in the left petroclival region invaded left internal carotid artery	Open procedure radical excision	3	–	Chemotherapy, ASCT	30	Stable
Nofsinger, 1997[76]	79	F	Unilateral blurred vision and diplopia	Slope mass extends to right sphenoid sinus	Endoscopic biopsy	1, 2	IgG-κ	Chemotherapy, local radiotherapy	–	Alleviate
Chen, 2023	60	F	Distending pain and diplopia of unilateral eye, blurred vision	Lesions in ethmoid sinus and sphenoid sinus, orbital apex with bone absorption	Endoscopic biopsy and partial excision	1–7	IgD-λ	Chemotherapy (VRd*1, D-PAD*2)	4	Death

Abbreviations: Allo-BMT, allogeneic bone marrow transplantation; Allo-SCT, allogeneic stem cell transplant; ASCT, autologous stem cell transplantation; BCD/VCD/CyBorD, Cyclophosphamide, Bortezomib, and Dexamethasone; BD-PACE, Bortezomib, Dexamethasone-Cisplatin, Cyclophosphamide, Etoposide, and Adriamycin; BMT, bone marrow transplantation; CR, complete response; DEDP-R, Dexamethasone and Lenalidomide; D-PAD, Daratumumab-Bortezomib, Doxorubicin liposomes, and Dexamethasone; DVD-R, Bortezomib, Lenalidomide, Pegylated liposomal doxorubicin, and Dexamethasone; E-KRd, Elotuzumab-Carfilzomib, Lenalidomide, and Dexamethasone; F, female; KRd, Carfilzomib, Lenalidomide, and Dexamethasone; M, male; M2, Carmustine, Cyclophosphamide, Vincristine, Melphalan, and Prednisone; MP, Melphalan and Prednisone; PBSCT, peripheral blood stem cell transplantation; PLD, Bortezomib, Lenalidomide, Pegylated liposomal doxorubicin; TD, Dexamethasone and Thalidomide; V, Bortezomib; VAD, Vincristine, Adriamycin, and Dexamethasone; VGPR, very good partial remission; VRD/VRd, Bortezomib, Lenalidomide, and Dexamethasone.

Note: 1: tissue biopsy; 2: bone marrow biopsy; 3: bone marrow aspiration/smear; 4: serum/urine protein electrophoresis; 5: immunofixation electrophoresis; 6: FISH; 7-PET-CT. “Alleviate” means symptoms have improved, but the lesions were not reduced or eliminated.

Case Report

A 60-year-old female presented with a 1-month history of right-eye distending pain and diplopia, which had progressed to include blurred vision over the past week (May 2023). Furthermore, she also reported experiencing dizziness and an unexplained weight loss of exceeding 5 kg over a period of 2 weeks. Notably, no symptoms were observed on the left side and no complaints of headache, nausea, or vomiting were reported. A visual assessment revealed a significant impairment, with acuity measurements of 0.02 in the right eye (OD) and 0.8 in the left eye (OS). The right eye exhibited ptosis, a fixed eyeball position, the absence of both direct and indirect light reflections, and visual field defects. Blood test results indicated a low red blood cell count (3.32*10¹²/L), hemoglobin (Hb; 98 g/L), and hematocrit (28.7%).

Radiological imaging ([Fig. 2]): the computed tomography (CT) scan in axial, coronal, and sagittal views revealed the presence of a mass within the right posterior ethmoid and sphenoid sinuses, exhibiting no discernible evidence of bone destruction (A–C). The enhanced magnetic resonance (MR) in axial, coronal, and sagittal views shows the mass in the right posterior ethmoid and sphenoid sinuses. This mass displays a notable degree of enhancement and extends to the orbital apex and the skull base meninges and the cavernous segment of the internal carotid artery (D–F).

Fig. 2 Radiological imaging. CT shows a mass in the right posterior ethmoid and sphenoid sinuses, with no obvious bone destruction (A–C). Enhanced MR shows the mass enhances significantly and extends to the orbital apex and the skull base meninges and the cavernous segment of the internal carotid artery (D–F). CT, computed tomography; MR, magnetic resonance.

A space-occupying lesion was diagnosed in the right orbital apex, sphenoid sinus, and skull base based on the clinical findings. A subsequent biopsy was conducted via an endoscopic transnasal approach, which enabled access to the ethmoidal and sphenoid sinuses, and conducting a biopsy of the skull base and orbital apex. The frozen pathology indicated the presence of a malignant small round-blue cell tumor. Further exploration revealed the tumor had extended into the orbital apex, implicating the optic nerve eminence and the internal carotid artery eminence. The tumor was resected from the former two locations but not from the latter.

Histopathology and immunohistochemistry results indicated a highly active plasma cell tumor, with multiple myeloma oncogene-1 (MUM-1) (+)[B, 100 × ], CD138 (+)[C, 200 × ], a high proliferation rate as indicated by Ki-67% (MIB-1) (80% + )[D, 400 × ] and lambda light-chain restriction [E, 400 × ] ([Fig. 3]). Minority of plasma cells demonstrate Kappa positivity [F, 400 × ], collectively signifying light-chain restriction. Sinus mucosa is infiltrated by sheets of extensive plasma cells [A, hematoxylin and eosin, 400 × ], displaying dislocated nuclei, high nu–plasma ratio, coarse nuclear chromatin, polymorphic nuclei, and occasional nucleolus. A positron emission tomography–CT scan identified a hypermetabolic mass in the vicinity of the iliopsoas muscle within the right pelvic cavity, in addition to multiple bone lesions with increased metabolism, anemia, and splenomegaly. Bone marrow aspiration and biopsy confirmed a segment of the pulp cavity devoid of activity, along with a widespread proliferation of plasma cells, consistent with plasma cell myeloma. Fluorescence in situ hybridization (FISH) revealed a TP53 deletion in 96% of cells at the 17p13.1(0) and 11q22.3(G) sites.

Fig. 3 Histopathology and immunohistochemical profile of the sphenoid sinus mass. Highly active plasma cell tumor [A, hematoxylin and eosin (H&E), 400 × ].MUM-1(+) [B, 100 × ], CD138(+) [C, 200 × ] and Ki-67% (MIB-1) 80%+ [D, 400 × ].Light-chain restriction of Lambda [E, 400 × ] and Kappa [F, 400 × ].

Subsequent to the biopsy and confirmation of the pathological diagnosis, the patient was referred to the hematology department for further treatment. The clinical diagnosis was IgD-λ MM, classified as either IIIa stage (DS stage) or II stage (R-ISS stage), with a TP53 deletion mutation and multiple extramedullary metastases, including a skull base mass and a right iliopsoas muscle mass.

After a course of VRd chemotherapy (Bortezomib, Lenalidomide, and Dexamethasone), the patient's right-eye vision improved somewhat, accompanied by a reduction in right waist and leg pain. A D-PAD (Daratumumab-Bortezomib, Doxorubicin liposomes, and Dexamethasone) regimen was subsequently administered. However, following three cycles of both VRd and D-PAD, the patient developed progressive weakness in the bilateral lower extremities, loss of acupuncture sensation, and muscle strength deficits in both proximal and distal areas. Tendon reflexes in the bilateral lower extremities were absent, and deep sensation below the hip joint was lost. A MR imaging (MRI) of the cervical, thoracolumbar region revealed the presence of lesions in the vertebrae, which were diagnosed as intraspinal extramedullary plasmacytoma exerting pressure on the thoracic spinal cord. Surgery was proposed but declined by the family. Maintenance chemotherapy with Doxorubicin liposome and Dexamethasone was administered, but the patient's condition did not significantly improve. Due to financial limitations, Selinexor was not pursued, and symptomatic supportive treatment was offered.

At this juncture, the patient's ocular symptoms had subsided, and vision had largely been restored. However, chemotherapy proved less effective, and new extramedullary lesions emerged in the context of highly malignant circumstances. A clear and effective therapeutic regimen was not available, and the patient's life expectancy was estimated at 3 months. The patient chose to return to her local area to alleviate suffering and passed away in September 2023.

Discussion

Epidemiology

MM stands as the second most prevalent hematological tumor globally, with a higher incidence in males than in females and a mean age of onset of 57 years. Although the occurrence of IgD and nonsecreted types of M protein is infrequent, research conducted in Europe and the United States has demonstrated that IgD accounts for a mere 1 to 2% of all MM cases.[1] [5] In contrast, this proportion is slightly higher in China, accounting for 5.2,[6] 6.9,[7] and even 11.7%.[8] IgD MM can be further categorized as λ (60–95%[9] [10] [11]) and κ based on the light chain type. Extramedullary disease (EM) is typically observed as a solitary case, and MM complicated with EM is uncommon. Among the 40 patients with MM and EM observed by Chen et al,[12] IgD MM accounted for only 10%. Extramedullary invasion occurred in 4% of the 664 MM cases reported by García-Sanz et al.[13] The patient we reported, a 60-year-old female with sphenoid sinus, orbital apex, and skull base as the initial sites, represents a relatively rare clinical presentation that is prone to misdiagnosis and missed diagnosis.

Clinical Manifestation

MM typically presents with a constellation of symptoms collectively known as “CRAB”, which encompass hypercalcemia, renal insufficiency, anemia, and bone destruction. Alternatively, it may manifest as an extramedullary plasma cell tumor, Bence–Jones protein in urine, weight loss, and other symptoms.[14] This wide range of symptoms can pose diagnostic challenges, given the diverse range of specialties involved. Bone pain is the initial presenting symptom in over 80% of MM patients.[15] Additionally, there have been reports of unconventional presentations, including central retinal vein obstruction,[16] hoarseness,[17] anaphylactoid purpura,[18] and vision loss.[19] In comparison to other types of MM, IgD MM is more likely to develop extramedullary infiltration.[20] The incidence of IgD-λ MM patients with EM at the initial diagnosis is approximately 7 to 18%, and the occurrence of EM during treatment is approximately 6 to 20%.[21] [22] [23] The patient we presented displayed evident ocular symptoms during the initial consultation, with imaging diagnostics revealing a mass occupying both the ethmoid and sphenoid sinuses, accompanied by osteolytic lesions located at the orbital apex. Further investigation is necessary to reach an accurate diagnosis.

Laboratory Examination

When Hb decreases, and globulin increases, but no significant abnormalities in white blood cell count or classification are evident in routine tests, serum immunoglobulin detection, serum protein electrophoresis (SPE), and blood/urine light chain detection should be performed in a timely manner.[24] In instances where there is a reduction in lipid levels,[25] decline in peripheral blood lymphocyte count, and an elevation in uric acid levels,[26] it is imperative that clinicians exercise heightened vigilance and undertake a comprehensive bone marrow analysis.

The identification of the M protein in either blood or urine is a crucial element in the diagnosis of MM. It is important to note that the absence of an M protein peak in SPE does not rule out MM. Immunofixation electrophoresis is a more effective diagnostic tool than SPE and urine Bence–Jones protein,[27] serving as the industry standard for identifying and classifying protein types through immunochemical techniques.[28] Additionally, serum-free light chain immunoassay is an early indicator for assessing efficacy and detecting minimal residual disease (MRD).[29] Another recently introduced index is β2-microglobulin, which is employed to assist in the diagnosis and evaluation of MM treatment effectiveness.

However, 5 to 10% of patients do not excrete M protein, which can result in clinical diagnosis difficulties.[30] Bone marrow analysis remains an indispensable test for the final determination of MM. Increased quantities of myeloma cells (MCs) can be observed in bone marrow aspiration and smear. Bone marrow biopsy can help eliminate misdiagnosis caused by localized hyperplasia lesions. Thus, bone marrow biopsy combined with smear is an effective means to improve the detection rate of MM.[31] Chromosomal translocations and IGH gene mutations detected by FISH are related to MC morphology, clinical subtypes, disease progression, chemotherapy sensitivity, and prognosis.[32] For instance, the deletion of 17p13 leads to the loss of tumor suppressor gene p53, resulting in poor prognosis, severe conditions, plasma cell tumors, and hypercalcemia.[33]

Histopathology

Histopathology is widely considered the definitive method for the diagnosis of MM. In cases where masses in the head and neck are difficult to diagnose, a pathological biopsy can be a quick and effective diagnostic tool. It does the need for a reminder that SRBCT (small round blue cell tumor) requires taking a conservative and thorough approach before rendering a diagnosis because of the pathological characteristics.[34] [35] CD138 is a surface antigen specific to MC and is utilized as an early detection marker in 100% of cases.[36] [37] Although CD38 also highly expresses in MC and myeloma stem cells, normal plasma cells express both markers as well.[38] CD56 is expressed in abnormal plasma cells, while CD19 is expressed in normal plasma cells but not or at low levels in MM cells. Malignant plasma cells are more likely to express CD56(+)/CD19(−), which enhances the combined specificity.[39] CD138, CD79α, and Cyclin D1 are highly expressed in MM. CD138, CD79α, and Cyclin D1 can be used as powerful diagnostic tools when no characteristic tumor cell space-occupying lesions are found in bone marrow samples.[40]

Imaging Manifestation

Regarding the intracranial involvement of MM extramedullary metastasis, CT can visually observe the bone destruction around the masses, and MRI can enable early detection of the soft tissue masses and assess the extent of mass infiltration. CT manifestations in MM with sphenoid sinus lesions typically include irregular soft tissue masses in the sphenoid sinus region presenting as isodensity, with poorly defined boundaries and peripheral osteolytic bone destruction.[41] The surrounding bone of lymphoma of sinus origin is predominantly characterized by insect erosion and osteolytic destruction, with a greater scope of soft tissue invasion than bone destruction.[42] The bone destruction is less severe than that observed in other sinus malignancies.[43] While the MR signal strength is nonspecific, the apparent diffusion coefficient can be used to initially identify the area.[44] [45]

Diagnosis

Diagnosing active MM follows established criteria outlined in the Multiple Myeloma Guidelines (2021) of NCCN and the International Myeloma Working Group guidelines. The aforementioned diagnostic criteria encompass the following elements: (1) a bone marrow biopsy revealing a proportion of plasma cells ≥10% or confirmation of plasmacytoma through biopsy of other tissues. (2) The presence of M protein in either serum or urine. (3) Identification of the “CRAB” symptoms, which includes C for hypercalcemia (serum calcium > 2.75 mmol/L), R for renal insufficiency (serum creatinine > 177 μmol/L), A for anemia (Hb < 100 g/L), and B for bone destruction, as indicated by the presence of single or multiple osteolytic lesions upon imaging examination. A diagnosis of active MM is made when criteria (1) and (2) are present, and at least one of the criteria outlined in (3) is met.[46] [47] Clinical staging systems, including Durie–Salmon, the International Staging System (ISS), and the Revised ISS (R-ISS), are frequently employed for the assessment of the disease extent. In the case we presented, the diagnosis was rigorously established following a comprehensive analysis.

Treatment

Effectively managing active MM necessitates a multifaceted approach that encompasses initial treatment, the prevention of bone disease, and symptomatic supportive care. For patients in good physical condition, ASCT is the preferred course of action following effective induction therapy. Induction therapy typically involves a three-drug combination regimen incorporating protease inhibitors (PIs) such as Bortezomib, immunomodulators (iMiDs) like Lenalidomide, and Dexamethasone. This regimen is primarily employed to initiate treatment. In some cases, a four-drug regimen, including the addition of Daratumumab, can yield improved postinduction outcomes, particularly with regard to MRD conversion. In instances of recurrent or refractory MM, a range of treatment options is considered, including PIs, iMiDs, Daratumumab, exportin 1 inhibitors (XPO1), such as Selinexor, and cytotoxic agents like Doxorubicin liposomes, with the overarching goal of enhancing patients' overall quality of life.[4]

Conclusion

Early diagnosis is crucial in IgD-λ MM presenting in the sphenoid sinus, orbital apex, and skull base due to its rapid progression and generally poor prognosis. Symptoms like diplopia and anemia should raise suspicion, prompting imaging for diagnosis. CT/MR scans show high-grade malignancy with characteristic bone destruction, necessitating a biopsy for definitive diagnosis. The trans-nasal endoscopic approach is favored due to minimal surgical trauma, requiring familiarity with localized anatomy. Recognition of anemia, lipid-level changes, and organ damage warrants thorough examination, including immunoglobulin assessment and bone marrow biopsy. For progressive cases, early induction chemotherapy followed by marrow transplantation post-surgery is recommended. Regular follow-up and symptomatic support are essential components of patient care.

Conflicts of Interest

None declared.

Trial Registration

Chen, Y., Liu, J. (September 12, 2023). Immunoglobulin D-Lambda Multiple Myeloma Initially Positioning in Orbital Apex and Skull Base: a Case Report and Scoping Reviews. Retrieved from: https://osf.io/wzafy// DOI: 10.17605/OSF.IO/WZAFY.

Author Contributions

J.L. was responsible for conceptualization, funding acquisition, project administration, supervision, and writing (review and editing). Y.C. handled data curation, formal analysis, investigation, methodology, resources, software, validation, visualization, and writing (original draft) and J.H. contributed to investigation, resources, and visualization.

Ethical Statements

The case study has gained institutional approval and informed consents.

• References

• 1 Kyle RA, Gertz MA, Witzig TE. et al. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc 2003; 78 (01) 21-33
• 2 Liu J, Hu X, Jia Y. et al. Clinical features and survival outcomes in IgD myeloma: a study by Asia Myeloma Network (AMN). Leukemia 2021; 35 (06) 1797-1802
• 3 Kumar SK, Callander NS, Adekola K. et al. Multiple Myeloma, Version 3.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 2020; 18 (12) 1685-1717
• 4 Chinese Hematology Association. Chinese Society of Hematology. Guidelines for the diagnosis and management of multiple myeloma in China (2022 version) [in Chinese]. Zhonghua Nei Ke Za Zhi 2022; 61 (05) 480-487
• 5 Morris C, Drake M, Apperley J. et al; Myeloma Subcommittee of Chronic Leukaemia Working Party of EBMT. Efficacy and outcome of autologous transplantation in rare myelomas. Haematologica 2010; 95 (12) 2126-2133
• 6 Mai YJ, Qiu LG, Li R. et al. The clinical and laboratory features of 432 patients with multiple myeloma. Journal Leukemia Lymphoma. 2004; 45 (02) 198-201
• 7 Chen S, Li Y, Zhang P, Zhai Y, Sun W, Su L. A clinical analysis of 798 cases of M protein positive patients [in Chinese]. Zhonghua Nei Ke Za Zhi 2001; 40 (06) 398-400
• 8 Zhuang JL, Wu YJ, Zhong YP. et al. Clinical analysis of 218 cases of multiple myeloma. Zhongguo Shiyong Neike Zazhi 2004; 24 (02) 108-110
• 9 Jancelewicz Z, Takatsuki K, Sugai S, Pruzanski W. IgD multiple myeloma. Review of 133 cases. Arch Intern Med 1975; 135 (01) 87-93
• 10 Lu J, Lu J, Chen W, Huo Y, Huang X, Hou J. Chinese Medical Doctor Association Hematology Branch. Clinical features and treatment outcome in newly diagnosed Chinese patients with multiple myeloma: results of a multicenter analysis. Blood Cancer J 2014; 4 (08) e239-e239
• 11 Bladé J, Lust JA, Kyle RA. Immunoglobulin D multiple myeloma: presenting features, response to therapy, and survival in a series of 53 cases. J Clin Oncol 1994; 12 (11) 2398-2404
• 12 Chen HF, Fu WJ, Wang DX, Yuan ZG, Chen YB, Hou J. Clinical features of multiple myeloma patients with extramedullary disease: a report of 40 cases from a single center [in Chinese]. Zhonghua Xue Ye Xue Za Zhi 2007; 28 (10) 655-658
• 13 García-Sanz R, Orfão A, González M. et al. Primary plasma cell leukemia: clinical, immunophenotypic, DNA ploidy, and cytogenetic characteristics. Blood 1999; 93 (03) 1032-1037
• 14 Kumar S, Paiva B, Anderson KC. et al. International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma. Lancet Oncol 2016; 17 (08) e328-e346
• 15 Terpos E, Ntanasis-Stathopoulos I, Gavriatopoulou M, Dimopoulos MA. Pathogenesis of bone disease in multiple myeloma: from bench to bedside. Blood Cancer J 2018; 8 (01) 7
• 16 Xue Y, Zhu RR, Chen H. The first diagnosis was two cases of multiple myeloma with central retinal vein obstruction in both eyes. Chinese J Ophthalmic Otolaryngology 2017; 17: 423-424
• 17 Yuan KL, Ren Y, Yang M. et al. A case of multiple myeloma with hoarseness as the primary symptom. Chinese Department of Otolaryngology Head and Neck Surgery 2021; 28: 144
• 18 Jiang M, Cheng F, Yi X. et al. Multiple myeloma with Henoch-Schonlein purpura as the initial manifestation: a case report. The Chinese J Dermatovenereology 2022; 46 (06) 1-6
• 19 Wachter D, Böker DK, Huegens-Penzel M, Kuchelmeister K, Jödicke A. First manifestation of lambda positive plasmacytoma in the orbital apex with acute unilateral loss of vision. Minim Invasive Neurosurg 2010; 53 (02) 74-76
• 20 Kim MK, Suh C, Lee DH. et al; Korean Multiple Myeloma Working Party. Immunoglobulin D multiple myeloma: response to therapy, survival, and prognostic factors in 75 patients. Ann Oncol 2011; 22 (02) 411-416
• 21 Li X, Huang ZX. Research progress on multiple myeloma with extramedullary disease. J Clin Oncol 2020; 26: 86-91
• 22 Bladé J, Fernández de Larrea C, Rosiñol L. Extramedullary disease in multiple myeloma in the era of novel agents. Br J Haematol 2015; 169 (06) 763-765
• 23 Lee SE, Kim JH, Jeon YW. et al. Impact of extramedullary plasmacytomas on outcomes according to treatment approach in newly diagnosed symptomatic multiple myeloma. Ann Hematol 2015; 94 (03) 445-452
• 24 Liu ZW, Li XT, Pang T. et al. The clinical value of routine tests in the diagnosis of multiple myeloma. J Clin Haematol 2021; 34: 48-52
• 25 Wei Y, Wang J, Chen F. et al. Serum abnormal metabolites for evaluating therapeutic response and prognosis of patients with multiple myeloma. Front Oncol 2022; 12: 808290
• 26 Xun ZM, Xu YL, Wang JY. et al. Laboratory study on early detection of multiple myeloma. Int J Lab Med. 2023; 44: 84-88
• 27 Wang JX, Zhao Y, Liu BX. et al. Significance of serum immunofixation electrophoresis in diagnosis of multiple myeloma. Guangdong Yixue 2011; 32: 2018-2020
• 28 Kraj M. Immunoglobulin heavy chain/light chain pairs (HLC, Hevylite™) assays for diagnosing and monitoring monoclonal gammopathies. Adv Clin Exp Med 2014; 23 (01) 127-133
• 29 Hu Y, Sun CY. Advances in the diagnosis of multiple myeloma. J Clin Haematol 2012; 25: 406-410
• 30 Chen HS, Liu EB, Wang TT. et al. Morphologic and clinical study of 131 cases of plasma cell myeloma [in Chinese]. Zhonghua Bing Li Xue Za Zhi 2004; 33 (01) 44-48
• 31 Zhou F, Lei C, Guo BY. et al. Comparison of diagnosis value of bone marrow smear and biopsy for multiple myeloma. Clin J MED Offic 2011; 39: 752-754
• 32 Wang SJ, Zhu LH. Multiple myeloma and its laboratory diagnosis. Chin J Lab Med 2004; 27 (04) 255-258
• 33 Fonseca R, Blood E, Rue M. et al. Clinical and biologic implications of recurrent genomic aberrations in myeloma. Blood 2003; 101 (11) 4569-4575
• 34 Lei W, Su Z, Wen W. et al. [Diagnosis of small round cell tumor of nasal sinus and bases of skull (a report of 123 cases)]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008; 22 (20) 929-933
• 35 Simons SA, Bridge JA, Leon ME. Sinonasal small round blue cell tumors: an approach to diagnosis. Semin Diagn Pathol 2016; 33 (02) 91-103
• 36 Ayed AO, Chang LJ, Moreb JS. Immunotherapy for multiple myeloma: current status and future directions. Crit Rev Oncol Hematol 2015; 96 (03) 399-412
• 37 García-Sanz R, Orfão A, González M. et al. Primary plasma cell leukemia: clinical, immunophenotypic, DNA ploidy, and cytogenetic characteristics. Blood 1999; 93 (03) 1032-1037
• 38 Wong SW, Comenzo RL. CD38 monoclonal antibody therapies for multiple myeloma. Clin Lymphoma Myeloma Leuk 2015; 15 (11) 635-645
• 39 Zhu P, Wu BQ, Ding TL. et al. Feature and significance of the cell immunophenotype of 30 multiple myeloma patients. J Med Res 2014; 43: 40-42
• 40 Tanaka T, Ichimura K, Sato Y. et al. Frequent downregulation or loss of CD79a expression in plasma cell myelomas: potential clue for diagnosis. Pathol Int 2009; 59 (11) 804-808
• 41 Weng YF, Qi RF, Lu GM. CT and MRI features of multiple myeloma associated with plasmacytoma located in the spheno-clival region: three cases and literature review. J Chin Clin Med Imaging. 2016; 27: 580-583
• 42 Zhu L, Fang P, Liu Y, Tong B. Clinical and diagnosis analysis of malignant lymphoma in nasal cavity and paranasal sinus [in Chinese]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2015; 29 (03) 255-257
• 43 Chen HJ, Yang YY, Zhao W. et al. Contrast⁃enhanced CT and MRI in differentiating squamous cell carcinoma of the nasal cavity and sinuses from lymphoma. J Pract Med 2024; 40: 394-399
• 44 Kato H, Kanematsu M, Watanabe H, Kawaguchi S, Mizuta K, Aoki M. Differentiation of extranodal non-Hodgkins lymphoma from squamous cell carcinoma of the maxillary sinus: a multimodality imaging approach. Springerplus 2015; 4: 228
• 45 Kawaguchi M, Kato H, Tomita H. et al. Imaging characteristics of malignant sinonasal tumors. J Clin Med 2017; 6 (12) 116
• 46 Luo ZY, Zhou FL. The 2019 National Comprehensive Cancer Network guidelines for the Diagnosis and treatment of multiple myeloma. J Clin Intern Med. 2020; 37: 71-72
• 47 Li HX, Hong H, Zhang JL. IgDλ type multiple myeloma involving sphenoid sinus with cerebral symptoms as first clinical presentation symptom: a case report. J Clin Oncol 2023; 29: 335-338
• 48 Liu Y, Sun J, Li H, Qian J. Clinical characteristics of multiple myeloma involving sphenoid sinus [in Chinese]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2013; 27 (05) 230-232
• 49 Shah CP, Chamlagain R, Shah S. et al. Multiple myeloma with plasmacytoma of the clivus bone presenting with multiple cranial nerve III, IV, and VI palsy: a diagnostic dilemma. Clin Case Rep 2023; 11 (02) e6958
• 50 Zuo XL. Neuropathy became the first manifestation of multiple myeloma. Zhonghua Xue Ye Xue Za Zhi 2002; 23 (04) 456-459
• 51 Qu S, Liao L, Xie Y, Zheng Z, Chen B. Intracranial involvement in newly diagnosed multiple myeloma with TP53 deletion: two case reports. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018; 43 (11) 1272-1275
• 52 Johnson JT, Bhakta PN, Vinnakota RD. etc.. Suprasellar Plasmacytoma Leading to the Diagnosis of Multiple Myeloma. Cureus 2022; 14 (06) e25831
• 53 Silverman RF, Hanson L, Salahi N, Li Z, Boruk M, Hodgson NM. Case report: cavernous sinus syndrome as the initial presentation of multiple myeloma. Front Ophthalmol (Lausanne) 2022; 2 (07) 849343
• 54 Joshi A, Jiang D, Singh P, Moffat D. Skull base presentation of multiple myeloma. Ear Nose Throat J 2011; 90 (01) E6-E9
• 55 Ustuner Z, Basaran M, Kiris T. et al. Skull base plasmacytoma in a patient with light chain myeloma. Skull Base 2003; 13 (03) 167-171
• 56 Hogan MC, Lee A, Solberg LA, Thome SD. Unusual presentation of multiple myeloma with unilateral visual loss and numb chin syndrome in a young adult. Am J Hematol 2002; 70 (01) 55-59
• 57 Yamaguchi S, Terasaka S, Ando S, Shinohara T, Iwasaki Y. Neoadjuvant therapy in a patient with clival plasmacytoma associated with multiple myeloma: a case report. Surg Neurol 2008; 70 (04) 403-407
• 58 Wein RO, Popat SR, Doerr TD, Dutcher PO. Plasma cell tumors of the skull base: four case reports and literature review. Skull Base 2002; 12 (02) 77-86
• 59 Alegre A, Tomás JF, Pinilla I, Gil-Fernández JJ, Fernández-Rañada JM. Multiple myeloma presenting as plasmacytoma of the base of the skull. Am J Hematol 1996; 52 (01) 60-61
• 60 Kadiri S. Multiple myeloma revealed by a sphenoid plasmocytoma: case report and literature review. Integrative Journal of Medical Sciences 2013; 3: 57-9
• 61 Humphrey DM, Aufdemorte TB, Gates GA. An IgD extramedullary plasmacytoma involving the sphenoid sinus at onset: an immunohistochemical study. Laryngoscope 1983; 93 (11, Pt 1): 1476-1480
• 62 Hess T, Egerer G, Kasper B, Rasul KI, Goldschmidt H, Kauffmann GW. Atypical manifestations of multiple myeloma: radiological appearance. Eur J Radiol 2006; 58 (02) 280-285
• 63 Liu J. Case reports: Central nervous system involvement in patients with newly diagnosed multiple myeloma. Front Neurol 2023; 14: 1072490
• 64 Yazdanpanah O, Kaur J, Shafi I, Sarakbi HA. Diplopia as the initial symptom of multiple myeloma in a patient with sarcoidosis. BMJ Case Rep 2020; 13 (08) e235725
• 65 Movsas TZ, Balcer LJ, Eggenberger ER, Hess JL, Galetta SL. Sixth nerve palsy as a presenting sign of intracranial plasmacytoma and multiple myeloma. J Neuroophthalmol 2000; 20 (04) 242-245
• 66 Bachmeyer C, Levy V, Carteret M. et al. Sphenoid sinus localization of multiple myeloma revealing evolution from benign gammopathy. Head Neck 1997; 19 (04) 347-350
• 67 Oushy S, Graffeo CS, Perry A, Morris JM, Carlson ML, Van Gompel JJ. Collet-Sicard syndrome attributable to extramedullary plasmacytoma of the jugular foramen. World Neurosurg 2018; 110: 386-390
• 68 Venkataswamy Reddy P, Singh V, Roy R, Yanamandra U. Multiple myeloma presenting as clival mass: a diagnostic dilemma. BMJ Case Rep 2021; 14 (03) e240670
• 69 Patel AJ, Adams GJ, Humphries WE. etc.. Multiple myeloma presenting as solitary mass in the posterior fossa. J Clin Neurosci 2010; 17 (11) 1457-9
• 70 Rahman EZ, Barros Palau AE, Morgan ML. etc.. Neuro-ophthalmic presentations of clival plasmacytoma. Can J Ophthalmol 2016; 51 (02) e49-53
• 71 How J, Johnson PC, Corrales CE. etc.. Sperling AS, Connell NT. Plasmacytoma presenting as jugular foramen tumor in a young woman with multiple myeloma. Am J Hematol 2019; 94 (06) 728-732
• 72 Magrassi L, Moretti E, Marchionni M, Rognone E, Maurizio B. Stereotactic biopsy approach to the upper clivus through the middle fossa floor that avoids pneumatised cavities and the intradural compartment. Acta Neurochir (Wien) 2016; 158 (04) 717-720
• 73 Shenoy K, Boloor A, Pai S, Suddharsan DS. Unusual presentation of multiple myeloma. Indian J Cancer 2010; 47 (03) 347-348
• 74 Rezazadeh A, Kloecker GH, Laber DA. etc.. Multiple Myeloma Presenting as a Clivus and Brain Stem Plasmacytoma. [J] Blood 2005; 106 (11) 5061
• 75 Higurashi M, Yagishita S, Fujitsu K, Kitsuta Y, Takemoto Y, Osano S. Plasma cell myeloma of the skull base: report of two cases. Brain Tumor Pathol 2004; 21 (03) 135-141
• 76 Nofsinger YC, Mirza N, Rowan PT, Lanza D, Weinstein G. Head and neck manifestations of plasma cell neoplasms. Laryngoscope 1997; 107 (06) 741-746
• 77 Du YP, Wu YQ, Zhu YF. etc.. Sphenoid sinus plasmacytoma as initial presentation of multiple myeloma: one case report and literature review[J]. . Journal of Practical Radiology 20992100
• 78 Wu DQ, Yao JS. Osteoplasmacytosarcoma of skull base: a case report[J]. Chinese Journal of Minimally Invasive Neurosurgery 2006; 11: 330-330
• 79 Lu SH, Li HG. A case of multiple myeloma with skull base invasion[J]. Journal of Clinical Radiology 2009; 28: 432-433
• 80 Chen DL, Yue ZJ. Multiple myeloma with cranial base plasmacytoma: a case report [J]. Guangxi Medical Journal 2003; 25: 2040-2041

Publikationsverlauf

Eingereicht: 29. Juni 2024

Angenommen: 13. August 2024

Artikel online veröffentlicht:
16. September 2024