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Semin Respir Crit Care Med 2024; 45(05): 560-573
DOI: 10.1055/s-0044-1792112
Review Article

Navigating COPD in Aging Populations: Insights Into Pathophysiology and Comprehensive Care

William T. Atchley
1   Division of Pulmonary and Critical Care Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas
,
Amy Montgomery
1   Division of Pulmonary and Critical Care Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas
,
Rohan Seth
2   Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas
,
Tanmay Gandhi
3   Division of Pulmonary, Allergy and Critical Care Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
,
Shannon Brewer
2   Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas
› Author Affiliations Funding None.
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Abstract

Chronic obstructive pulmonary disease (COPD) poses a significant and growing health burden among aging populations, marked by increasing prevalence and complex management challenges specific to elderly patients. This review explores the multifaceted interplay between COPD and aging, highlighting overlapping pathophysiological processes and comorbidities that complicate diagnosis and treatment. We examine age-specific management strategies, emphasizing the need for tailored approaches that account for the unique physical, cognitive, and health-related quality of life impacts on older adults. Additionally, we discuss preventive treatments and the critical roles of mental health, end-of-life care, and caregiver support in comprehensive disease management. The importance of integrative approaches to enhancing health care delivery is also underscored. Finally, we outline future directions, focusing on novel treatment pathways and the identification of biomarkers for early detection. Addressing these elements is essential for optimizing care in this vulnerable population and alleviating the significant societal and economic impacts of COPD among aging patients.

Keywords

aging - COPD - management strategies - pharmacological treatments - comprehensive care


Publication History

Article published online:
12 November 2024

© 2024. Thieme. All rights reserved.

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  • References

  • 1 Hardie JA, Vollmer WM, Buist AS, Bakke P, Mørkve O. Respiratory symptoms and obstructive pulmonary disease in a population aged over 70 years. Respir Med 2005; 99 (02) 186-195
    CrossrefPubMedSearch in Google Scholar
  • 2 Kohansal R, Martinez-Camblor P, Agustí A, Buist AS, Mannino DM, Soriano JB. The natural history of chronic airflow obstruction revisited: an analysis of the Framingham offspring cohort. Am J Respir Crit Care Med 2009; 180 (01) 3-10
    CrossrefPubMedSearch in Google Scholar
  • 3 Chapman KR, Mannino DM, Soriano JB. et al. Epidemiology and costs of chronic obstructive pulmonary disease. Eur Respir J 2006; 27 (01) 188-207
    CrossrefPubMedSearch in Google Scholar
  • 4 Murgia N, Gambelunghe A. Occupational COPD-the most under-recognized occupational lung disease?. Respirology 2022; 27 (06) 399-410
    CrossrefPubMedSearch in Google Scholar
  • 5 Buist AS, McBurnie MA, Vollmer WM. et al; BOLD Collaborative Research Group. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet 2007; 370 (9589): 741-750
    CrossrefPubMedSearch in Google Scholar
  • 6 Boers E, Barrett M, Su JG. et al. Global burden of chronic obstructive pulmonary disease through 2050. JAMA Netw Open 2023; 6 (12) e2346598
    CrossrefPubMedSearch in Google Scholar
  • 7 Agusti A, Faner R. Lung function trajectories in health and disease. Lancet Respir Med 2019; 7 (04) 358-364
    CrossrefPubMedSearch in Google Scholar
  • 8 Dieleman JL, Cao J, Chapin A. et al. US health care spending by payer and health condition, 1996-2016. JAMA 2020; 323 (09) 863-884
    CrossrefPubMedSearch in Google Scholar
  • 9 Duan KI, Birger M, Au DH, Spece LJ, Feemster LC, Dieleman JL. Health care spending on respiratory diseases in the united states, 1996-2016. Am J Respir Crit Care Med 2023; 207 (02) 183-192
    CrossrefPubMedSearch in Google Scholar
  • 10 Mannino DM, Roberts MH, Mapel DW. et al. National and local direct medical cost burden of COPD in the United States From 2016 to 2019 and projections through 2029. Chest 2024; 165 (05) 1093-1106
    CrossrefPubMedSearch in Google Scholar
  • 11 Rehman AU, Hassali MAA, Muhammad SA, Harun SN, Shah S, Abbas S. The economic burden of chronic obstructive pulmonary disease (COPD) in Europe: results from a systematic review of the literature. Eur J Health Econ 2020; 21 (02) 181-194
    CrossrefPubMedSearch in Google Scholar
  • 12 Chen S, Kuhn M, Prettner K. et al. The global economic burden of chronic obstructive pulmonary disease for 204 countries and territories in 2020-50: a health-augmented macroeconomic modelling study. Lancet Glob Health 2023; 11 (08) e1183-e1193
    CrossrefPubMedSearch in Google Scholar
  • 13 Atwood CE, Bhutani M, Ospina MB. et al. Optimizing COPD acute care patient outcomes using a standardized transition bundle and care coordinator: a randomized clinical trial. Chest 2022; 162 (02) 321-330
    CrossrefPubMedSearch in Google Scholar
  • 14 Yan C, Round J, Akpinar I. et al. Cost analysis of a transition care bundle compared with usual care for COPD patients being discharged from hospital: evaluation of a randomized controlled trial. PharmacoEconom Open 2023; 7 (03) 493-505
    CrossrefPubMedSearch in Google Scholar
  • 15 Mosher CL, Nanna MG, Jawitz OK. et al. Cost-effectiveness of pulmonary rehabilitation among US adults with chronic obstructive pulmonary disease. JAMA Netw Open 2022; 5 (06) e2218189
    CrossrefPubMedSearch in Google Scholar
  • 16 Gauderman WJ, Urman R, Avol E. et al. Association of improved air quality with lung development in children. N Engl J Med 2015; 372 (10) 905-913
    CrossrefPubMedSearch in Google Scholar
  • 17 Rennard SI. COPD: overview of definitions, epidemiology, and factors influencing its development. Chest 1998; 113 (4, Suppl): 235S-241S
    CrossrefPubMedSearch in Google Scholar
  • 18 Mannino DM. COPD: epidemiology, prevalence, morbidity and mortality, and disease heterogeneity. Chest 2002; 121 (5, Suppl): 121S-126S
    CrossrefPubMedSearch in Google Scholar
  • 19 Lundbäck B, Lindberg A, Lindström M. et al; Obstructive Lung Disease in Northern Sweden Studies. Not 15 but 50% of smokers develop COPD?–Report from the obstructive lung disease in Northern Sweden Studies. Respir Med 2003; 97 (02) 115-122
    CrossrefPubMedSearch in Google Scholar
  • 20 Kc R, Shukla SD, Gautam SS, Hansbro PM, O'Toole RF. KC R. The role of environmental exposure to non-cigarette smoke in lung disease. Clin Transl Med 2018; 7 (01) 39
    CrossrefPubMedSearch in Google Scholar
  • 21 Coggon D, Newman Taylor A. Coal mining and chronic obstructive pulmonary disease: a review of the evidence. Thorax 1998; 53 (05) 398-407
    CrossrefPubMedSearch in Google Scholar
  • 22 Lytras T, Beckmeyer-Borowko A, Kogevinas M. et al. Cumulative occupational exposures and lung-function decline in two large general-population cohorts. Ann Am Thorac Soc 2021; 18 (02) 238-246
    CrossrefPubMedSearch in Google Scholar
  • 23 Kalacić I. Ventilatory lung function in cement workers. Arch Environ Health 1973; 26 (02) 84-85
    CrossrefPubMedSearch in Google Scholar
  • 24 Hessel PA, Melenka LS, Michaelchuk D, Herbert FA, Cowie RL. Lung health among plumbers and pipefitters in Edmonton, Alberta. Occup Environ Med 1998; 55 (10) 678-683
    CrossrefPubMedSearch in Google Scholar
  • 25 Sigsgaard T, Basinas I, Doekes G. et al. Respiratory diseases and allergy in farmers working with livestock: a EAACI position paper. Clin Transl Allergy 2020; 10 (01) 29
    CrossrefPubMedSearch in Google Scholar
  • 26 Cui L, Gallagher LG, Ray RM. et al. Unexpected excessive chronic obstructive pulmonary disease mortality among female silk textile workers in Shanghai, China. Occup Environ Med 2011; 68 (12) 883-887
    CrossrefPubMedSearch in Google Scholar
  • 27 Andersson E, Sällsten G, Lohman S, Neitzel R, Torén K. Lung function and paper dust exposure among workers in a soft tissue paper mill. Int Arch Occup Environ Health 2020; 93 (01) 105-110
    CrossrefPubMedSearch in Google Scholar
  • 28 Peña VS, Miravitlles M, Gabriel R. et al. Geographic variations in prevalence and underdiagnosis of COPD: results of the IBERPOC multicentre epidemiological study. Chest 2000; 118 (04) 981-989
    CrossrefPubMedSearch in Google Scholar
  • 29 Verbeken EK, Cauberghs M, Mertens I, Clement J, Lauweryns JM, Van de Woestijne KP. The senile lung. Comparison with normal and emphysematous lungs. 1. Structural aspects. Chest 1992; 101 (03) 793-799
    PubMedSearch in Google Scholar
  • 30 Brandenberger C, Mühlfeld C. Mechanisms of lung aging. Cell Tissue Res 2017; 367 (03) 469-480
    CrossrefPubMedSearch in Google Scholar
  • 31 Skloot GS. The effects of aging on lung structure and function. Clin Geriatr Med 2017; 33 (04) 447-457
    CrossrefPubMedSearch in Google Scholar
  • 32 Sharma G, Goodwin J. Effect of aging on respiratory system physiology and immunology. Clin Interv Aging 2006; 1 (03) 253-260
    CrossrefPubMedSearch in Google Scholar
  • 33 Scichilone N, Messina M, Battaglia S, Catalano F, Bellia V. Airway hyperresponsiveness in the elderly: prevalence and clinical implications. Eur Respir J 2005; 25 (02) 364-375
    CrossrefPubMedSearch in Google Scholar
  • 34 López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell 2013; 153 (06) 1194-1217
    CrossrefPubMedSearch in Google Scholar
  • 35 López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: an expanding universe. Cell 2023; 186 (02) 243-278
    CrossrefPubMedSearch in Google Scholar
  • 36 Kakkera K, Atchley WT, Kodali M, Bartter T. Ageing and chronic obstructive pulmonary disease: interrelationships. Curr Opin Pulm Med 2023; 29 (02) 90-95
    CrossrefPubMedSearch in Google Scholar
  • 37 Lowery EM, Brubaker AL, Kuhlmann E, Kovacs EJ. The aging lung. Clin Interv Aging 2013; 8: 1489-1496
    PubMedSearch in Google Scholar
  • 38 Tsuji T, Aoshiba K, Nagai A. Alveolar cell senescence in patients with pulmonary emphysema. Am J Respir Crit Care Med 2006; 174 (08) 886-893
    CrossrefPubMedSearch in Google Scholar
  • 39 Rutten EPA, Gopal P, Wouters EFM. et al. Various mechanistic pathways representing the aging process are altered in COPD. Chest 2016; 149 (01) 53-61
    CrossrefPubMedSearch in Google Scholar
  • 40 Mannino DM, Buist AS. Global burden of COPD: risk factors, prevalence, and future trends. Lancet 2007; 370 (9589): 765-773
    CrossrefPubMedSearch in Google Scholar
  • 41 Raherison C, Girodet P-O. Epidemiology of COPD. Eur Respir Rev 2009; 18 (114) 213-221
    CrossrefPubMedSearch in Google Scholar
  • 42 Divo MJ, Celli BR, Poblador-Plou B. et al; EpiChron—BODE Collaborative Group. Chronic obstructive pulmonary disease (COPD) as a disease of early aging: Evidence from the EpiChron Cohort. PLoS ONE 2018; 13 (02) e0193143
    CrossrefPubMedSearch in Google Scholar
  • 43 Sabit R, Bolton CE, Edwards PH. et al. Arterial stiffness and osteoporosis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007; 175 (12) 1259-1265
    CrossrefPubMedSearch in Google Scholar
  • 44 Patel BD, Loo WJ, Tasker AD. et al. Smoking related COPD and facial wrinkling: is there a common susceptibility?. Thorax 2006; 61 (07) 568-571
    CrossrefPubMedSearch in Google Scholar
  • 45 Quanjer PH, Stanojevic S, Cole TJ. et al; ERS Global Lung Function Initiative. Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations. Eur Respir J 2012; 40 (06) 1324-1343
    CrossrefPubMedSearch in Google Scholar
  • 46 Hall GL, Filipow N, Ruppel G. et al; contributing GLI Network members. Official ERS technical standard: Global Lung Function Initiative reference values for static lung volumes in individuals of European ancestry. Eur Respir J 2021; 57 (03) 2000289
    CrossrefPubMedSearch in Google Scholar
  • 47 Graham BL, Steenbruggen I, Miller MR. et al. Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement. Am J Respir Crit Care Med 2019; 200 (08) e70-e88
    CrossrefPubMedSearch in Google Scholar
  • 48 Bush A. Lung development and aging. Ann Am Thorac Soc 2016; 13 (Suppl. 05) S438-S446
    CrossrefPubMedSearch in Google Scholar
  • 49 Bhakta NR, Bime C, Kaminsky DA. et al. Race and ethnicity in pulmonary function test interpretation: an official American Thoracic Society Statement. Am J Respir Crit Care Med 2023; 207 (08) 978-995
    CrossrefPubMedSearch in Google Scholar
  • 50 Baugh A, Adegunsoye A, Connolly M. et al. Towards a race-neutral system of PFT interpretation. Chest 2023; 164: 727-733
    CrossrefPubMedSearch in Google Scholar
  • 51 Incalzi RA, Scarlata S, Pennazza G, Santonico M, Pedone C. Chronic obstructive pulmonary disease in the elderly. Eur J Intern Med 2014; 25 (04) 320-328
    CrossrefPubMedSearch in Google Scholar
  • 52 Agustí A, Celli BR, Criner GJ. et al. Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary. Eur Respir J 2023; 61 (04) 2300239
    CrossrefPubMedSearch in Google Scholar
  • 53 Quanjer PH, Brazzale DJ, Boros PW, Pretto JJ. Implications of adopting the Global Lungs Initiative 2012 all-age reference equations for spirometry. Eur Respir J 2013; 42 (04) 1046-1054
    CrossrefPubMedSearch in Google Scholar
  • 54 Belo J, Palmeiro T, Caires I. et al. Reference values for spirometry in elderly individuals: a cross-sectional study of different reference equations. Multidiscip Respir Med 2018; 13 (01) 4
    CrossrefPubMedSearch in Google Scholar
  • 55 Haynes JM, Kaminsky DA, Stanojevic S, Ruppel GL. Pulmonary function reference equations: a brief history to explain all the confusion. Respir Care 2020; 65 (07) 1030-1038
    CrossrefPubMedSearch in Google Scholar
  • 56 de Marco R, Accordini S, Marcon A. et al; European Community Respiratory Health Survey (ECRHS). Risk factors for chronic obstructive pulmonary disease in a European cohort of young adults. Am J Respir Crit Care Med 2011; 183 (07) 891-897
    CrossrefPubMedSearch in Google Scholar
  • 57 Vollmer WM, Gíslason T, Burney P. et al. Comparison of spirometry criteria for the diagnosis of COPD: results from the BOLD study. Eur Respir J 2009; 34 (03) 588-597
    CrossrefPubMedSearch in Google Scholar
  • 58 Schermer TRJ, Smeele IJM, Thoonen BPA. et al. Current clinical guideline definitions of airflow obstruction and COPD overdiagnosis in primary care. Eur Respir J 2008; 32 (04) 945-952
    CrossrefPubMedSearch in Google Scholar
  • 59 Stanojevic S, Kaminsky DA, Miller MR. et al. ERS/ATS technical standard on interpretive strategies for routine lung function tests. Eur Respir J 2022; 60 (01) 2101499
    CrossrefPubMedSearch in Google Scholar
  • 60 Hanania NA, Sharma G, Sharafkhaneh A. COPD in the elderly patient. Semin Respir Crit Care Med 2010; 31 (05) 596-606
    Thieme ConnectPubMedSearch in Google Scholar
  • 61 Matera MG, Hanania NA, Maniscalco M, Cazzola M. Pharmacotherapies in older adults with COPD: challenges and opportunities. Drugs Aging 2023; 40 (07) 605-619
    CrossrefPubMedSearch in Google Scholar
  • 62 Taffet GE, Donohue JF, Altman PR. Considerations for managing chronic obstructive pulmonary disease in the elderly. Clin Interv Aging 2014; 9: 23-30
    PubMedSearch in Google Scholar
  • 63 Nazir SA, Erbland ML. Chronic obstructive pulmonary disease: an update on diagnosis and management issues in older adults. Drugs Aging 2009; 26 (10) 813-831
    CrossrefPubMedSearch in Google Scholar
  • 64 Cote CG, Celli BR. Pulmonary rehabilitation and the BODE index in COPD. Eur Respir J 2005; 26 (04) 630-636
    CrossrefPubMedSearch in Google Scholar
  • 65 Cawkwell PB, Blaum C, Sherman SE. Pharmacological smoking cessation therapies in older adults: a review of the evidence. Drugs Aging 2015; 32 (06) 443-451
    CrossrefPubMedSearch in Google Scholar
  • 66 Leone FT, Zhang Y, Evers-Casey S. et al. Initiating pharmacologic treatment in tobacco-dependent adults. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med 2020; 202 (02) e5-e31
    CrossrefPubMedSearch in Google Scholar
  • 67 van Eerd EA, van der Meer RM, van Schayck OC, Kotz D. Smoking cessation for people with chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2016; 2016 (08) CD010744
    CrossrefPubMedSearch in Google Scholar
  • 68 Tønnesen P. Smoking cessation and COPD. Eur Respir Rev 2013; 22 (127) 37-43
    CrossrefPubMedSearch in Google Scholar
  • 69 Selby P, Zawertailo L. Tobacco addiction. N Engl J Med 2022; 387 (04) 345-354
    CrossrefPubMedSearch in Google Scholar
  • 70 Albertson TE, Schivo M, Zeki AA. et al. The pharmacological approach to the elderly COPD patient. Drugs Aging 2013; 30 (07) 479-502
    CrossrefPubMedSearch in Google Scholar
  • 71 Weinberger B, Grubeck-Loebenstein B. Vaccines for the elderly. Clin Microbiol Infect 2012; 18 (Suppl. 05) 100-108
    CrossrefPubMedSearch in Google Scholar
  • 72 Mohr A, Kloos M, Schulz C. et al. Low adherence to pneumococcal vaccination in lung cancer patients in a tertiary care university hospital in Southern Germany. Vaccines (Basel) 2022; 10 (02) 311
    CrossrefPubMedSearch in Google Scholar
  • 73 Felzer JR, Montgomery AJ, LeMahieu AM. et al. Disparities in influenza, pneumococcal, COVID-19 vaccine coverage in high-risk adults aged 19 to 64 years in Southeastern Minnesota, 2010-2021. Chest 2024; 166 (01) 49-60
    CrossrefPubMedSearch in Google Scholar
  • 74 Mulpuru S, Li L, Ye L. et al; Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research Network (CIRN). Effectiveness of influenza vaccination on hospitalizations and risk factors for severe outcomes in hospitalized patients with COPD. Chest 2019; 155 (01) 69-78
    CrossrefPubMedSearch in Google Scholar
  • 75 Gershon AS, Chung H, Porter J. et al. Influenza vaccine effectiveness in preventing hospitalizations in older patients with chronic obstructive pulmonary disease. J Infect Dis 2020; 221 (01) 42-52
    CrossrefPubMedSearch in Google Scholar
  • 76 Riley CM, Sciurba FC. Diagnosis and outpatient management of chronic obstructive pulmonary disease: a review. JAMA 2019; 321 (08) 786-797
    CrossrefPubMedSearch in Google Scholar
  • 77 Guilleminault L, Rolland Y, Didier A. Particularités de la prise en charge non médicamenteuse de la BPCO chez les sujets âgés. Réhabilitation, sevrage tabagique, nutrition et éducation thérapeutique. [Characteristics of non-pharmacological interventions in the elderly with COPD. Smoking cessation, pulmonary rehabilitation, nutritional management and patient education]. Rev Mal Respir 2018; 35 (06) 626-641
    CrossrefPubMedSearch in Google Scholar
  • 78 Henoch I, Strang S, Löfdahl C-G, Ekberg-Jansson A. Management of COPD, equal treatment across age, gender, and social situation? A register study. Int J Chron Obstruct Pulmon Dis 2016; 11: 2681-2690
    CrossrefPubMedSearch in Google Scholar
  • 79 Katsura H, Kanemaru A, Yamada K, Motegi T, Wakabayashi R, Kida K. Long-term effectiveness of an inpatient pulmonary rehabilitation program for elderly COPD patients: comparison between young-elderly and old-elderly groups. Respirology 2004; 9 (02) 230-236
    CrossrefPubMedSearch in Google Scholar
  • 80 Nishi SPE, Zhang W, Kuo Y-F, Sharma G. Pulmonary rehabilitation utilization in older adults with chronic obstructive pulmonary disease, 2003 to 2012. J Cardiopulm Rehabil Prev 2016; 36 (05) 375-382
    CrossrefPubMedSearch in Google Scholar
  • 81 Spitzer KA, Stefan MS, Priya A. et al. Participation in pulmonary rehabilitation after hospitalization for chronic obstructive pulmonary disease among Medicare beneficiaries. Ann Am Thorac Soc 2019; 16 (01) 99-106
    CrossrefPubMedSearch in Google Scholar
  • 82 Vestbo J, Hurd SS, Agustí AG. et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2013; 187 (04) 347-365
    CrossrefPubMedSearch in Google Scholar
  • 83 Yohannes AM, Hardy CC. Treatment of chronic obstructive pulmonary disease in older patients: a practical guide. Drugs Aging 2003; 20 (03) 209-228
    CrossrefPubMedSearch in Google Scholar
  • 84 Hanania NA, Dransfield MT, Goehring U-M, Lakkis H, Rowe P. Efficacy Of roflumilast in elderly patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2011; 183: A3087-A3087
    PubMedSearch in Google Scholar
  • 85 Rabe KF, Calverley PMA, Martinez FJ, Fabbri LM. Effect of roflumilast in patients with severe COPD and a history of hospitalisation. Eur Respir J 2017; 50 (01) 1700158
    CrossrefPubMedSearch in Google Scholar
  • 86 Kendzerska T, Aaron SD, To T. et al. Effectiveness and safety of inhaled corticosteroids in older individuals with chronic obstructive pulmonary disease and/or asthma. A population study. Ann Am Thorac Soc 2019; 16 (10) 1252-1262
    CrossrefPubMedSearch in Google Scholar
  • 87 Mkorombindo T, Dransfield MT. Inhaled corticosteroids in chronic obstructive pulmonary disease: benefits and risks. Clin Chest Med 2020; 41 (03) 475-484
    CrossrefPubMedSearch in Google Scholar
  • 88 Chapman KR, Love L, Brubaker H. A comparison of breath-actuated and conventional metered-dose inhaler inhalation techniques in elderly subjects. Chest 1993; 104 (05) 1332-1337
    CrossrefPubMedSearch in Google Scholar
  • 89 Grandmaison G, Grobéty T, Vaucher J, Hayoz D, Suter P. Prevalence of critical errors and insufficient peak inspiratory flow in patients hospitalized with COPD in a Department of General Internal Medicine: a cross-sectional study. Chronic Obstr Pulm Dis (Miami) 2024; 11 (04) 406-415
    PubMedSearch in Google Scholar
  • 90 Bao LK, Khoa ND, Chi LTK, Anh NT. Prevalence and factors affecting appropriate inhaler use in elderly patients with chronic obstructive pulmonary disease: a prospective study. J Clin Med 2023; 12 (13) 4420
    CrossrefPubMedSearch in Google Scholar
  • 91 Cho-Reyes S, Celli BR, Dembek C, Yeh K, Navaie M. Inhalation technique errors with metered-dose inhalers among patients with obstructive lung diseases: a systematic review and meta-analysis of U.S. studies. Chronic Obstr Pulm Dis (Miami) 2019; 6 (03) 267-280
    PubMedSearch in Google Scholar
  • 92 Molimard M, Raherison C, Lignot S. et al. Chronic obstructive pulmonary disease exacerbation and inhaler device handling: real-life assessment of 2935 patients. Eur Respir J 2017; 49 (02) 1601794
    CrossrefPubMedSearch in Google Scholar
  • 93 Jarvis S, Ind PW, Shiner RJ. Inhaled therapy in elderly COPD patients; time for re-evaluation?. Age Ageing 2007; 36 (02) 213-218
    CrossrefPubMedSearch in Google Scholar
  • 94 Allen SC, Ragab S. Ability to learn inhaler technique in relation to cognitive scores and tests of praxis in old age. Postgrad Med J 2002; 78 (915) 37-39
    CrossrefPubMedSearch in Google Scholar
  • 95 Iamthanaporn C, Wisitsartkul A, Chuaychoo B. Cognitive impairment according to Montreal Cognitive Assessment independently predicts the ability of chronic obstructive pulmonary disease patients to maintain proper inhaler technique. BMC Pulm Med 2023; 23 (01) 144
    CrossrefPubMedSearch in Google Scholar
  • 96 Allen SC. Competence thresholds for the use of inhalers in people with dementia. Age Ageing 1997; 26 (02) 83-86
    CrossrefPubMedSearch in Google Scholar
  • 97 Dodd JW, Getov SV, Jones PW. Cognitive function in COPD. Eur Respir J 2010; 35 (04) 913-922
    CrossrefPubMedSearch in Google Scholar
  • 98 Al-Showair RAM, Tarsin WY, Assi KH, Pearson SB, Chrystyn H. Can all patients with COPD use the correct inhalation flow with all inhalers and does training help?. Respir Med 2007; 101 (11) 2395-2401
    CrossrefPubMedSearch in Google Scholar
  • 99 Mahler DA, Waterman LA, Gifford AH. Prevalence and COPD phenotype for a suboptimal peak inspiratory flow rate against the simulated resistance of the Diskus® dry powder inhaler. J Aerosol Med Pulm Drug Deliv 2013; 26 (03) 174-179
    CrossrefPubMedSearch in Google Scholar
  • 100 Vincken W, Levy ML, Scullion J, Usmani OS, Dekhuijzen PNR, Corrigan CJ. Spacer devices for inhaled therapy: why use them, and how?. ERJ Open Res 2018; 4 (02) 00065-02018
    CrossrefPubMedSearch in Google Scholar
  • 101 Levy ML, Dekhuijzen PNR, Barnes PJ. et al. Inhaler technique: facts and fantasies. A view from the Aerosol Drug Management Improvement Team (ADMIT). NPJ Prim Care Respir Med 2016; 26 (01) 930-937
    PubMedSearch in Google Scholar
  • 102 Jones PW. Issues concerning health-related quality of life in COPD. Chest 1995; 107 (5 Suppl): 187S-193S
    CrossrefPubMedSearch in Google Scholar
  • 103 Martinez CH, Diaz AA, Parulekar AD. et al; COPDGene and SPIROMICS Investigators. Age-related differences in health-related quality of life in copd: an analysis of the COPDGene and SPIROMICS cohorts. Chest 2016; 149 (04) 927-935
    CrossrefPubMedSearch in Google Scholar
  • 104 Parulekar AD, Martinez C, Tsai C-L. et al. Examining the effects of age on health outcomes of chronic obstructive pulmonary disease: results from the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease Study and Evaluation of Chronic Obstructive Pulmonary Disease Longitudinally to Identify Predictive Surrogate Endpoints Cohorts. J Am Med Dir Assoc 2017; 18 (12) 1063-1068
    CrossrefPubMedSearch in Google Scholar
  • 105 Berry CE, Han MK, Thompson B. et al. Older adults with chronic lung disease report less limitation compared with younger adults with similar lung function impairment. Ann Am Thorac Soc 2015; 12 (01) 21-26
    CrossrefPubMedSearch in Google Scholar
  • 106 Błachnio A, Buliński L. Prejudices and elderly patients' personality – the problem of quality of care and quality of life in geriatric medicine. Med Sci Monit 2013; 19: 674-680
    CrossrefPubMedSearch in Google Scholar
  • 107 Bossenbroek L, de Greef MHG, Wempe JB, Krijnen WP, Ten Hacken NHT. Daily physical activity in patients with chronic obstructive pulmonary disease: a systematic review. COPD 2011; 8 (04) 306-319
    CrossrefPubMedSearch in Google Scholar
  • 108 Donaire-Gonzalez D, Gimeno-Santos E, Balcells E. et al. Physical activity in COPD patients: patterns and bouts. Eur Respir J 2013; 42 (04) 993-1002
    CrossrefPubMedSearch in Google Scholar
  • 109 McGlone S, Venn A, Walters EH, Wood-Baker R. Physical activity, spirometry and quality-of-life in chronic obstructive pulmonary disease. COPD 2006; 3 (02) 83-88
    CrossrefPubMedSearch in Google Scholar
  • 110 Garcia-Aymerich J, Félez MA, Escarrabill J. et al. Physical activity and its determinants in severe chronic obstructive pulmonary disease. Med Sci Sports Exerc 2004; 36 (10) 1667-1673
    CrossrefPubMedSearch in Google Scholar
  • 111 Mewes R, Rief W, Kenn K, Ried J, Stenzel N. Psychological predictors for health-related quality of life and disability in persons with chronic obstructive pulmonary disease (COPD). Psychol Health 2016; 31 (04) 470-486
    CrossrefPubMedSearch in Google Scholar
  • 112 Blakemore A, Dickens C, Guthrie E. et al. Depression and anxiety predict health-related quality of life in chronic obstructive pulmonary disease: systematic review and meta-analysis. Int J Chron Obstruct Pulmon Dis 2014; 9: 501-512
    CrossrefPubMedSearch in Google Scholar
  • 113 Kühl K, Schürmann W, Rief W. Mental disorders and quality of life in COPD patients and their spouses. Int J Chron Obstruct Pulmon Dis 2008; 3 (04) 727-736
    CrossrefPubMedSearch in Google Scholar
  • 114 Siebeling L, Musoro JZ, Geskus RB. et al. Prediction of COPD-specific health-related quality of life in primary care COPD patients: a prospective cohort study. NPJ Prim Care Respir Med 2014; 24 (01) 14060
    CrossrefPubMedSearch in Google Scholar
  • 115 Yohannes AM, Baldwin RC, Connolly MJ. Mood disorders in elderly patients with chronic obstructive pulmonary disease. Rev Clin Gerontol 2000; 10 (02) 193-202
    CrossrefPubMedSearch in Google Scholar
  • 116 Pollok J, van Agteren JE, Carson-Chahhoud KV. Pharmacological interventions for the treatment of depression in chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2018; 12 (12) CD012346
    PubMedSearch in Google Scholar
  • 117 Yohannes AM, Baldwin RC, Connolly MJ. Depression and anxiety in elderly patients with chronic obstructive pulmonary disease. Age Ageing 2006; 35 (05) 457-459
    CrossrefPubMedSearch in Google Scholar
  • 118 Maurer J, Rebbapragada V, Borson S. et al; ACCP Workshop Panel on Anxiety and Depression in COPD. Anxiety and depression in COPD: current understanding, unanswered questions, and research needs. Chest 2008; 134 (4 Suppl): 43S-56S
    CrossrefPubMedSearch in Google Scholar
  • 119 Yohannes AM, Connolly MJ, Baldwin RC. A feasibility study of antidepressant drug therapy in depressed elderly patients with chronic obstructive pulmonary disease. Int J Geriatr Psychiatry 2001; 16 (05) 451-454
    CrossrefPubMedSearch in Google Scholar
  • 120 Kunik ME, Braun U, Stanley MA. et al. One session cognitive behavioural therapy for elderly patients with chronic obstructive pulmonary disease. Psychol Med 2001; 31 (04) 717-723
    CrossrefPubMedSearch in Google Scholar
  • 121 Garlo K, O'Leary JR, Van Ness PH, Fried TR. Burden in caregivers of older adults with advanced illness. J Am Geriatr Soc 2010; 58 (12) 2315-2322
    CrossrefPubMedSearch in Google Scholar
  • 122 Knauft E, Nielsen EL, Engelberg RA, Patrick DL, Curtis JR. Barriers and facilitators to end-of-life care communication for patients with COPD. Chest 2005; 127 (06) 2188-2196
    CrossrefPubMedSearch in Google Scholar
  • 123 Curtis JR. Palliative and end-of-life care for patients with severe COPD. Eur Respir J 2008; 32 (03) 796-803
    CrossrefPubMedSearch in Google Scholar
  • 124 Fried TR, Vaz Fragoso CA, Rabow MW. Caring for the older person with chronic obstructive pulmonary disease. JAMA 2012; 308 (12) 1254-1263
    CrossrefPubMedSearch in Google Scholar
  • 125 Malemud CJ. Matrix metalloproteinases (MMPs) in health and disease: an overview. Front Biosci 2006; 11 (01) 1696-1701
    CrossrefPubMedSearch in Google Scholar
  • 126 Hoekstra R, Eskens FALM, Verweij J. Matrix metalloproteinase inhibitors: current developments and future perspectives. Oncologist 2001; 6 (05) 415-427
    CrossrefPubMedSearch in Google Scholar
  • 127 Mukhopadhyay S, Sypek J, Tavendale R. et al. Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults. J Allergy Clin Immunol 2010; 126 (01) 70-6.e16
    CrossrefPubMedSearch in Google Scholar
  • 128 Mocchegiani E, Giacconi R, Costarelli L. Metalloproteases/anti-metalloproteases imbalance in chronic obstructive pulmonary disease: genetic factors and treatment implications. Curr Opin Pulm Med 2011; 17 (Suppl. 01) S11-S19
    CrossrefPubMedSearch in Google Scholar
  • 129 Anzueto A, Barjaktarevic IZ, Siler TM. et al. Ensifentrine, a novel phosphodiesterase 3 and 4 inhibitor for the treatment of chronic obstructive pulmonary disease: randomized, double-blind, placebo-controlled, multicenter phase III trials (the ENHANCE Trials). Am J Respir Crit Care Med 2023; 208 (04) 406-416
    CrossrefPubMedSearch in Google Scholar
  • 130 Cosio M, Ghezzo H, Hogg JC. et al. The relations between structural changes in small airways and pulmonary-function tests. N Engl J Med 1978; 298 (23) 1277-1281
    CrossrefPubMedSearch in Google Scholar
  • 131 Hogg JC, McDonough JE, Suzuki M. Small airway obstruction in COPD: new insights based on micro-CT imaging and MRI imaging. Chest 2013; 143 (05) 1436-1443
    CrossrefPubMedSearch in Google Scholar
  • 132 Stockley JA, Ismail AM, Hughes SM, Edgar R, Stockley RA, Sapey E. Maximal mid-expiratory flow detects early lung disease in α1-antitrypsin deficiency. Eur Respir J 2017; 49 (03) 1602055
    CrossrefPubMedSearch in Google Scholar
  • 133 Schermer T, Malbon W, Newbury W. et al. Spirometry and impulse oscillometry (IOS) for detection of respiratory abnormalities in metropolitan firefighters. Respirology 2010; 15 (06) 975-985
    CrossrefPubMedSearch in Google Scholar
  • 134 Faner R, Tal-Singer R, Riley JH. et al; ECLIPSE Study Investigators. Lessons from ECLIPSE: a review of COPD biomarkers. Thorax 2014; 69 (07) 666-672
    CrossrefPubMedSearch in Google Scholar
  • 135 Carolan BJ, Hughes G, Morrow J. et al. The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes. Respir Res 2014; 15 (01) 127
    CrossrefPubMedSearch in Google Scholar
  • 136 Wątroba M, Dudek I, Skoda M, Stangret A, Rzodkiewicz P, Szukiewicz D. Sirtuins, epigenetics and longevity. Ageing Res Rev 2017; 40: 11-19
    CrossrefPubMedSearch in Google Scholar
  • 137 Baker JR, Vuppusetty C, Colley T. et al. Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells. Sci Rep 2016; 6 (01) 35871
    CrossrefPubMedSearch in Google Scholar