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Semin Thromb Hemost
DOI: 10.1055/s-0044-1796630
Review Article

Regulatory Effect of PDGF/PDGFR on Hematopoiesis

Yong Liu   *
1   Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China
2   Pediatric Hematology Laboratory, Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China
,
Junbin Huang   *
2   Pediatric Hematology Laboratory, Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China
,
Lindi Li   *
2   Pediatric Hematology Laboratory, Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China
,
Yifei Duan
2   Pediatric Hematology Laboratory, Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China
,
Beng H. Chong
3   Haematology Research Unit, School of Clinical Medicine, St George and Sutherland Campus, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia
4   New South Wales Health Pathology, St George Hospital, Kogarah, New South Wales, Australia
,
Liang Li
2   Pediatric Hematology Laboratory, Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China
,
Mo Yang
1   Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China
2   Pediatric Hematology Laboratory, Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China
5   Department of Hematology, Affiliated Hospital of Guangdong Medical University (GDMU), Zhanjiang, Guangdong, China
› Author Affiliations Funding This research was supported by the Shenzhen Science and Technology Innovation Commission Fund (JCYJ20230807110419041 to M.Y.).
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Abstract

Platelet-derived growth factor (PDGF) is a critical cytokine with substantial regulatory effects on hematopoiesis. Recent research highlights the essential role of PDGF in the modulation of hematopoietic stem/progenitor cells (HSPCs), megakaryocytes/platelets, and thrombopoietin (TPO) synthesis within the bone marrow microenvironment. PDGF directly stimulates the proliferation and differentiation of HSPCs while also inhibiting apoptosis. In addition, PDGF indirectly enhances the production of other growth factors, including granulocyte–macrophage colony-stimulating factors. Further, PDGF regulates TPO production and influences the bone marrow milieu, thus impacting hematopoiesis and platelet formation. Mechanistically, PDGF binds to its receptor, PDGF receptor (PDGFR), thus activating the PDGF/PDGFR signaling pathway. This pathway subsequently activates phosphoinositide 3-kinase/protein kinase B, leading to the activation of downstream cytokines, including c-Fos and NF-E2, while inhibiting caspase-3 activation. Collectively, these actions have prodifferentiation and antiapoptotic effects on megakaryocytes, thereby regulating platelet production. This review provides a comprehensive analysis of the regulatory role of the PDGF/PDGFR axis in hematopoiesis, with a particular focus on platelet production, by summarizing all studies on PDGF/PDGFR from our group and globally.

Keywords

platelet-derived growth factor - platelet-derived growth factor receptor - hematopoietic stem/progenitor cells - megakaryocytes - platelets

Authors' Contributions

Y.L., J.H., L.L., and Y.D. wrote the manuscript. B.H.C., Liang Li, and M.Y. reviewed, edited, and revised the manuscript. All authors read and approved the final article.


* These authors contributed equally to this article.




Publication History

Article published online:
28 November 2024

© 2024. Thieme. All rights reserved.

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