Endoscopy 1999; 31(9): 761-767
DOI: 10.1055/s-1999-75
Review
Georg Thieme Verlag Stuttgart ·New York

Adverse Effects of Nonsteroidal Anti-Inflammatory Drugs on the Small and Large Bowel

A. R. J. Schneider 1 , C. Benz 1 , C. Beermann 2 , A. Schiebeler 3 , J. F. Riemann 1
  • Medical Department C, Gastroenterology, Hepatology and Diabetes Care, Klinikum Ludwigshafen, Academic Hospital of the University of Mainz, Germany
Further Information

Publication History

Publication Date:
31 December 1999 (online)

Nonsteroidal anti-inflammatory drugs (NSAID) account for a large part of prescriptions and self-administered medication worldwide. The adverse effects on the upper gastrointestinal tract are well documented. However, in an increasing number of publications adverse effects in the small and large intestine distal to the duodenum are being reported. This paper provides an updated review of current as well as earlier literature on the pathogenesis of such adverse effects and the potential damage to the small and large bowel caused by NSAID. In addition, suggestions for an appropriate diagnostic workup of NSAID damage are discussed.

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A.R. J. Schneider

Medical Department C

Klinikum Ludwigshafen

Bremserstrasse 79

67063 Ludwigshafen

Germany

Phone: + 49-621-503-4114