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Aktuelle Urol 1999; 30(7): 449-460
DOI: 10.1055/s-1999-8963
ÜBERSICHTSARBEIT
Georg Thieme Verlag Stuttgart ·New York

Oral-medikamentöse Therapie der erektilen Dysfunktion: Grundlagen, Spektrum und Grenzen

Oral Treatment of Erectile Dysfunction: Background, Spectrum and LimitationsJ. E. Altwein1 , W. F. Thon2
  • 1Urologische Klinik, Krankenhaus der Barmherzigen Brüder, München
  • 2Urologische Klinik, Klinikum Hannover/Krankenhaus Siloah
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Publication History

Publication Date:
31 December 1999 (online)

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Zusammenfassung

Das Behandlungsspektrum der erektilen Dysfunktion (ED) spannt sich von der oral-medikamentösen Therapie bis zur Implantation einer Penisprothese. Die bedarfsangepaßte („on demand”) Tabletteneinnahme wird von der Mehrzahl der Patienten mit ED bevorzugt. In der Kategorie der zentralen Initiatoren der Erektion ist die wichtigste Substanz Apomorphin SL, dessen klinische Prüfungen abgeschlossen sind. In der Kategorie der peripheren Konditioner der Erektion stehen die klinischen Prüfungen der Phentolamidinmesylat oral vor dem Abschluß. Die innovativste Substanz dieser Kategorie ist Sildenafil, der erste Phosphodiesterase-5-Hemmer, der in Deutschland zugelassen ist.

Abstract

The therapeutic spectrum of erectile dysfunction comprises the oral-medical therapy at one end and the implantation of a penile prothesis at the other end. The majority of patients with erectile dysfunction favours the intake of tablets „on demand”. In the category of central initiators of erection, apomorphine SL is the most important compound, the clinical trials are now completed. In the category of peripheral conditioners of erection, the clinical trials with phentolaminmesylate per os are about to be concluded. The true novel substance in this category is sildenalfil, the first phosphodiesterase-5-inhibitor which has been approved in Germany.

Key words:

Erectile dysfunction - Oral treatment.

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Prof. Dr. med. J. E. Altwein

Chefarzt an der Urologischen Abteilung Krankenhaus der Barmherzigen Brüder

Romanstr. 93

80639 München