FREQUENT PRESENCE OF HELICOBACTER PYLORI GENOME IN THE SALIVA OF PATIENTS WITH HYPEREMESIS GRAVIDARUM

Satoshi Hayakawa; Noriko Nakajima; Miki Karasaki-Suzuki; Haruki Yoshinaga; Yasuyuki Arakawa; Kazuo Satoh; Tatsuo Yamamoto

doi:10.1055/s-2000-10005

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Am J Perinatol 2000; Volume 17(Number 05): 243-248
DOI: 10.1055/s-2000-10005

FREQUENT PRESENCE OF HELICOBACTER PYLORI GENOME IN THE SALIVA OF PATIENTS WITH HYPEREMESIS GRAVIDARUM

Satoshi Hayakawa¹ , Noriko Nakajima² , Miki Karasaki-Suzuki¹ , Haruki Yoshinaga¹ , Yasuyuki Arakawa² , Kazuo Satoh¹ , Tatsuo Yamamoto¹

¹Department of Obstetrics & Gynaecology, Nihon University School of Medicine, Tokyo, Japan
²Third Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan

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Publication Date:
31 December 2000 (online)

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ABSTRACT

Recently, possible involvement of Helicobacter pylori (H. pylori) in hyperemesis gravidarum have been reported based on serological studies and the therapeutic effects of antibiotics. In this study, we examined for the presence of H. pylori genome [by (PCR) of saliva] in combination with serological techniques. Thirty-four patients with hyperemesis and 29 normal pregnant subjects were examined for serum anti-H. pylori IgG antibodies and PCR of saliva. By serum antibody test, 16 of 34 hyperemesis patients (47.5%) were positive for anti-H. pylori IgG antibody, while 6 of 29 control subjects (20.6%) were positive (χ² p < 0.0005). PCR revealed positive H. pylori genome in 21 cases out of 34 hyperemesis (61.8%, 14 of 16 patients positive for H. pylori antibody and 7 of H. pylori-antibody-negative 18 patients) and 8 of 29 control subjects (27.6%) (χ² p < 0.000001). We suggest chronic infection of H. pylori as one of the important factors on the pathogenesis of hyperemesis gravidarum even though it may not be the single cause of the disorder.

KEYWORD

Helicobacter pylori; Hyperemesis gravidarum - latent gastritis - PCR

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