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Exp Clin Endocrinol Diabetes 2000; Vol. 108(8): 494-497
DOI: 10.1055/s-2000-11002
DOI: 10.1055/s-2000-11002
Mini-Review
© Johann Ambrosius Barth
Current perspectives of biotechnological replacement of insulin secreting cells
Further Information
Publication History
Publication Date:
31 December 2000 (online)
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Key words:
Genetic engineering - β-cell replacement, transplantation
References
- 1 Bailey C J, Davies E L, Docherty K. Prospects for insulin delivery by ex-vivo somatic cell gene therapy. J Mol Med . 97 (in press), 2000;
- 2 Bretzel R G, Hopt U T, Schatz H. Transplantations in patients with diabetes mellitus. Exp Clin Endo Diabetes. 108 241-243 2000;
- 3 Efrat S. Cell-based therapy for insulin-dependent diabetes mellitus. European Journal of Endocrinology. 138 129-133 1998;
- 4 Falqui L, Berra C, Severini G M, Martinengli S, Monti L D, Taglietti V, Pozza G, Bordignon C. Production of mature human insulin by retrovirally engineered fibroblasts and primary hepatocytes. Exp Clin Endo Diabetes. 104 A36 1996;
- 5 Ferber S, Halkin A, Cohen H, Ber I, Einav Y, Goldberg I, Barshack I, Seijfers R, Kopolovic J, Kaiser N, Karasik A. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates steptozotocin-induced hyperglycemia. Nature Medicine. 6 568-572 1999;
- 6 Lipes M A, Davalli A M, Cooper E M. Genetic engineering of insulin expression in nonislet-cells: implications for β-cell replacement therapy for insulin-dependent diabetes mellitus. Acta Diabetologia. 34 2-5 1997;
- 7 Moore H-P H, Walker M D, Lee F, Kelly R B. Expressing a human proinsulin cDNA in a mouse ACTH secreting cell. Cell. 35 531-538 1983;
- 8 Newgard C B. Cellular engineering and gene therapy strategies for insulin replacement in diabetes. Diabetes. 43 341-350 1994;
- 9 Pfeiffer E F. The “Ulm Zucker Uhr” system and its consequences. Horm Metab Res. 26 510-515 1994;
- 10 Tietge M, Lenzen S. Gene therapy of diabetes mellitus - aims, methods and future prospects. Experimental Clinical Endocrinology & Diabetes. 103 46-55 1995;
Prof. Dr. A. F. H. Pfeiffer
Department of Clinical Nutrition, German Institute of Nutrition
Arthur-Scheunert-Allee 114-116
D-14558 Potsdam-Rehbrücke
Department of Nutrition, Endocrinology and Metabolism
Free University of Berlin
Clinic Benjamin Franklin
Hindenburgdamm 30
D-12200 Berlin
Email: AFHP@www.dife.de