Semin Thromb Hemost 2000; 26(5): 479-484
DOI: 10.1055/s-2000-13203
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

A Pathway Leading to Hypoxia-Induced Vascular Fibrin Deposition

Shi-Fang Yan, David J. Pinsky, David M. Stern
  • Departments of Surgery, Medicine and Physiology and Cellular Biophysics, College of Physicians and Surgeons of Columbia University, New York, New York
Further Information

Publication History

Publication Date:
31 December 2000 (online)

ABSTRACT

Hypoxemia has long been associated with vascular fibrin formation leading to thrombosis. This review describes a pathway through which mononuclear phagocytes and vascular smooth muscle cells upregulate tissue factor under hypoxic conditions. Increased expression of tissue factor triggers events leading to vascular fibrin deposition, providing insight into a novel mechanism potentially underlying thrombosis in ischemic vasculature.

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