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Viszeralchirurgie 2000; 35(4): 288-290
DOI: 10.1055/s-2000-6910
KASUISTIK
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© Georg Thieme Verlag Stuttgart · New York

M. Castleman - seltene Differenzialdiagnose eines retroperitonealen Tumors

A. Schaper1 C. Langer2 T. Liersch2 R. Schlemminger3
  • 1Giftinformationszentrum Nord, Zentrum Pharmakologie und Toxikologie, Universität Göttingen (Direktor: Prof. Dr. med. H. F. Kahl)
  • 2Klinik und Poliklinik für Allgemeinchirurgie, Universität Göttingen (Direktor: Prof. Dr. med. H. Becker)
  • 3 Klinik für Allgemein- und Viszeralchirurgie, Reinhard-Nieter-Krankenhaus, Wilhelmshaven
Further Information

Publication History

Publication Date:
31 December 2000 (online)

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Zusammenfassung.

Beim M. Castleman handelt es sich um eine seltene lymphoproliferative Erkrankung im Sinne eines Prälymphoms. Ätiologisch und pathogenetisch kommen einer Infektion mit dem humanen Herpes Virus 8 sowie einem Anstieg des Immunmodulators Interleukin 6 eine gewisse Rolle zu. Überlappungssyndrome mit verschiedenen Autoimmunerkrankungen werden beschrieben. Therapeutische Ansätze stellen die Operation und verschiedene Chemotherapie-Schemata dar. In unserer Klinik exstirpierten wir bei einem 61-jährigen Patienten einen linksseitigen retroperitonealen Tumor, der sich als zirkumskripter M. Castleman herausstellte. Eingriff und postoperativer Verlauf waren unauffällig; eine weitere adjuvante Therapie war nicht erforderlich.

M. Castleman - rare differential diagnosis of a retroperitoneal tumor.

Castleman's disease is a lymphoproliferative disorder nowadays understood as a prelymphoma. Infection with human herpes virus 8 and an increase of interleukin 6 seem to play an important role in etiology and pathogenesis. Associations with several autoimmune diseases do exist and therapy consists of surgery and chemotherapy. In our hospital we excided a tumor from the left retroperitoneum in a 61 year old patient. Histologically it was a localized Castleman's disease. Surgery and hospital stay were without any complication and there was no indication for further adjuvant therapy.

Schlüsselwörter:

M. Castleman - lymphoproliferative Erkrankung - zwei Subtypen - HHV 8 - AIDS

Key words:

M. Castleman - lymphoproliferative disorder - 2 types - HHV 8 - AIDS

Literatur

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Dr. med. A. Schaper

Giftinformationszentrum Nord Zentrum Pharmakologie und Toxikologie

Universität Göttingen

Robert Koch-Str. 40

37075 Göttingen