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DOI: 10.1055/s-2000-7358
Östrogenersatztherapie und Koronare Herzerkrankung
Publication History
Publication Date:
31 December 2000 (online)
Über die Indikation zur Hormonersatztherapie in der Menopause bei der koronaren Herzerkrankung, deren positive Wirkung und auch deren potenzielle Nebenwirkungen herrscht häufig eine große Unsicherheit. Das kann dazu führen, dass Patientinnen einerseits günstige Effekte durch zu enge Indikationsstellung vorenthalten werden. Andererseits ist bei zu weiter Indikationsstellung oder Verordnung eines »falschen Hormonpräparates« mit Nebenwirkungen zu rechnen, die in keinem adäquaten Verhältnis zu den günstigen Wirkungen stehen. In dieser Arbeit soll eine Übersicht über die Wirksamkeit und Sicherheit der Hormonersatztherapie bei koronarer Herzkrankheit anhand des derzeitigen Standes der Literatur gegeben werden.
Literatur
- 1 Andersson B, Mattsson L, Hahn L, Märin P, Lapidus L, Hohn G, Bengtsson B, Björntorp B. Estrogen replacement therapy decreases hyperandrogenecity and improves glucose homeostasis and plasma lipids in postmenopausal women with noninsulin dependent diabetes mellitus. J Clin Endocrinol Metabol. 1997; 82 638-643
- 2 Bounameaux H, de Moerloose P, Campanne A. Contraception orale et substitution hormonale de la menopause. Schweiz Med Wschr. 1996; 126 1756-1763
- 3 Collaborative study of cardiovascular disease and steroid hormone contraception. Contraception. 1998; 57 315-324
- 4 Col N F, Eckmann M H, Karas R H, Paucker S G, Goldberg R J, Ross E M, Orr R K, Wong J B. Patient-specific decisions about hormone replacement therapy in postmenopausal womens. J Am Med Ass. 1997; 277 1140-1147
- 5 Colditz G A, Willett W C, Stampfer M J. et al . Menopause and the risk of coronary heart disease in women. N Engl J Med. 1987; 316 1105-1110
- 6 Colditz G A, Hankinson S E, Hunter D J. et al . The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med. 1995; 332 1589-1593
- 7 Daly E, Vessey M P, Hawkins M M. et al . Risk of venous thromboembolism in users of hormone replacement therapy. Lancet. 1996; 348 977-980
- 8 Dunn N, Thorogood M, Faragher B. et al . Oral contraceptives and myocardial infarction: results of the MICA case-control study. Brit Med J. 1999; 318 1579-1584
- 9 Ettinger P, Friedman G D, Bush R, Quesenburg jr C P. Reduced mortality associated with long-term postmenopausal estrogen therapy. Obstet Gynecol. 1996; 87 1-7
- 10 Folsorn A R, Mink P J, Selleres T A, Hong C P, Zheng W, Potter J D. Hormonal replacement therapy and morbidity and mortality in a prospective study of postmenopausal women. Am J Public Health. 1995; 85 1128-1132
- 11 Gorsky R D, Koplan J P. et al . Relative risks and benefits of longterm estrogen replacement therapy. Obstet Gynecol. 1994; 83 161-166
- 12 Grady D, Rubin S M, Petitti D, Fox C S, Black D, Ettinger B, Ernster V, Cummings S R. Hormone replacement therapy to prevent disease and prolong life in postmenopausal women. Ann Int Med. 1992; 117 1038-1041
- 13 Grodstein F, Stampfer M J, Colditz G A. Postmenopausal hormone therapy and mortality. N Engl J Med. 1997; 336 1769-1775
- 14 Grodstein F, Stampfer M J, Manson J E, Colditz G A, Willet W C, Rosner B, Speizer F, Hennekens C H. Postmenopausal estrogen and progestin use and the risk of cardiovascular disaese. N Engl J Med. 1996; 335 453-461
- 15 Grodstein F, Stampfer M J, Goldhaber S Z, Manson J E, Coldis G A, Speizer F E, Willett W C, Hennekens C H. Prospective study of exogenous hormones and risk of pulmonary embolism in women. Lancet. 1996; 248 1183-1186
- 16 Hennekens C H. Hormone replacement therapy: Current perspectives and future directions. Eur Heart J. 1997; 19 1362-1363
- 17 Hertfelder H J, Hanfland P. Blutgerinnungsveränderungen unter Ovulationshemmung, in der Schwangerschaft und in der Postmenopause. Herz/Kreislauf. 1999; 31 109-112
- 18 Hulley S, Grady D, Bush T, Furberg C, Herrington D, Vittinghoff E. for the Heart and Estrogen/Progestin Replacement study (HERS) research group . Rado○ized ▾rial of e▴▾roge plu▴ proge▴▾i for ▴ecodar▮ preve▾io of coroar▮ hear▾ di▴ea▴e i po▴▾○eopau▴al wo○e. J Am Med Ass. 1998; 280 605-623
- 19 Jick H, Derby L E, Myers M W, Vasilaikis C, Newton K M. Risk of hosptital admission for idiopathic venous thromboembolism among users of postmenopausal estrogens. Lancet. 1996; 348 981-983
- 20 Jordan V C. Designer-Östrogene: Neuartige Prävention gegen Brustkrebs und Osteoporose. Spektrum der Wissenschaft. 1999; ✗ 66-73
- 21 Koh K K, Mincemoyer R, Bui B N, Csako G, Pucino F, Guetta V, Waclawiw M, Cannon R O. Effects of hormone replacement therapy on fibrinolysis in postmenopausal women. N Engl J Med. 1997; 336 683-690
- 22 Kommission Hormontoxikologie der Deutschen Gesellschaft für Endokrinologie . Östrogen/Gestagen-Substitution während und nach den Wechseljahren. Endokrinologie. 1996; 20 122-125
- 23 Mant J, Painter R, Vessey M. Risk of myocardial infarction, angina and stroke in users of oral contraceptives: updated analysis of a cohort study. Br J Obstet Gynaekcol. 1998; 105 890-896
- 24 Mendelsohn M E, Karas R H. Mechanism of Disease: The protective effects of Estrogen on the cardiovascular system. N Engl J Med. 1999; 340 1801
- 25 O`Brian J E, Peterson E D, Keeler G P. Relation between estrogen replacement therapy and restenosis after percutaneous coronary interventions. J Am Coll Cardiol. 1996; 28 1111-1118
- 26 Oger E, Scarabin P Y. Assessment of the risk for venous thromboembolism among users of the hormone replacement therapy. Drugs Aging. 1999; 14 55-61
- 27 Peterson L. Estrogen replacement therapy and coronary heart disease. Curr Opin Cardiol. 1998; 13 223-231
- 28 Psaty B M, Heckbert S R, Atkins D. et al . The risk of myocardial infarction associated with the combined use of estrogen and progestin in postmenopausal women. Arch Int Med. 1994; 154 1333-1339
- 29 Rich-Edwards J W, Manson J, Hennekens C H, Buring J E. The primary prevention of coronary heart disease in women. N Engl J Med. 1995; 332 1758-1766
- 30 Rich-Edwards J W, Hennekens C H. Postmenopuasal hormones and coronary heart disease. Curr Opin Cardiol. 1996; 12 440-446
- 31 Ringe J D, Nickelsen T h. Raloxifen. Arzneimitteltherapie. 1999; 17 113-120
- 32 Schunkert H, Danser A H-J, Hense H, Derks F H-M, Kürzinger S, Rigger G A-J. Effects of estrogen replacement therapy of the renin-angiotensin system in postmenopausal women. Circulation. 1997; 95 39-45
- 33 Sherif K. Benefits and risks of oral contraceptives. Am J Obstet Gynecol. 1999; 180 343-348
- 34 Skouby S O. Oral contraceptives and venous thrombosis: End of the debate?. Eur J Contracept Reprod Health Care. 1998; 3 59-64
- 35 Stadel B V. Oral contraceptives and cardiovascular disease. N Engl J Med. 1993; 328 1069-1075
- 36 Stampfer M J, Willett W C, Colditz G A, Rosner B, Speizer F E, Hennekens C H. A prospective study of the meonopausal estrogen therapy and coronary heart disease. N Engl J Med. 1985; 313 1044-1049
- 37 Stampfer M J, Colditz G A, Willett W C. et al . Postmenopausal estrogen therapy and cardiovascular disease. N Engl J Med. 1991; 325 756-762
- 38 Stampfer M J, Colditz G A. Estrogen replacement therapy and coronary heart disase: A quantitative assessment of the epidemiologic evidence. Prev Med. 1991; 20 47-63
- 39 Sullivan J M, El-Zeky F, Vander Zwang R, Ramanathan K B. Effect on survival of estrogen replacement therapy after coronary artery bypass grafting. Am J Cardiol. 1997; 79 847-850
- 40 Sourander L, Rajala T, Makinen I. et al . Cardiovascular and cancer morbidity and mortality and sudden cardiac death in postmenopausal women on estrogen replacement therapy. Lancet. 1998; 352 1965-1969
- 41 Todd J, Lawrenson R, Farmer R D, Williams T J, Leyden G M. Venous thromboembolic disease and combined oral contraceptives: A reanalysis of the MedPlus database. Hum Reprod. 1999; 14 1500-1005
- 42 Weiss G. Risk of venous thromboembolism with third generation oral contraceptives. A review. Am J Obstet Gynecol. 1999; 180 295-301
- 43 The writing group for the PEPI trial . Effects of estrogen or Estrogen/Progestin Regimens on heart disease: Risk factors in postmenopausal women. The postmenopausal Estrogen/Progestin interventions(PEPI) trial. J Am Med Ass. 1995; 273 199-208
- 44 Windler E. Prävention kardiovaskulärer Erkrankungen durch Hormonsubstitution in der Postmenopause. Zentralbl Gynäkol. 1996; 118 188-197
Korrespondenz
Privatdozent Dr. W. Lengfelder
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Minden
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