A New Steroidal Saponin from the Leaves of Agave americana

Abstract

A new bisdesmosidic spirostanol saponin, along with three known saponins, were isolated from Agave americana (Agavaceae). The structure of the new saponin was elucidated as (25R)-3β,6α-dihydroxy-5α-spirostan-12-one 3,6-di-O-β-D-glucopyranoside. Among the isolated saponins, hecogenin tetraglycoside showed cytotoxic activity against HL-60 human promyelocytic leukemia cells with an IC₅₀ value of 4.3 μg/mL.

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