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Planta Med 2000; 66(5): 483-484
DOI: 10.1055/s-2000-8583
DOI: 10.1055/s-2000-8583
Letter
Georg Thieme Verlag Stuttgart · New York
Cytotoxic Triterpene Acids from the Peruvian Medicinal Plant Polylepis racemosa
Further Information
Publication History
Publication Date:
31 December 2000 (online)
![](https://www.thieme-connect.de/media/plantamedica/200005/lookinside/thumbnails/10.1055-s-2000-8583-1.jpg)
Abstract
Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI50 values of 6.9 and 8.3 μg/mL respectively.
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Dr. Gerald B. Hammond
Department of Chemistry and Biochemistry University of Massachussetts-Dartmouth
North Dartmouth
MA 02747
U.S.A.
Email: ghammond@umassd.edu
Phone: +1-508-999-9167