Cytotoxic Triterpene Acids from the Peruvian Medicinal Plant Polylepis racemosa

Abstract

Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI₅₀ values of 6.9 and 8.3 μg/mL respectively.

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