Inducible Nitric Oxide Synthase Inhibitors from Saposhnikovia divaricata and Panax quinquefolium

Abstract

A series of polyacetylenes, falcarinone, panaxynol, falcarindiol, panaxydol, and panaxytriol, were isolated from Saposhnikovia divaricata (Turcz.) Schischk and Panax quinquefolium L. These polyacetylenes were identified as active principles on the inhibition of nitrite production by inducible nitric oxide synthase (iNOS). Treatment with 10 μM of panaxynol, falcarindiol, panaxydol and panaxytriol decreased the LPS/IFN-γ-stimulated accumulation of nitrite by 71.92 ± 3.07, 69.95 ± 3.68, 45.48 ± 6.11 and 36.85 ± 8.80 %, respectively. The IC₅₀ value of falcarinone, panaxynol, falcarindiol, panaxydol and panaxytriol was > 20, 2.23, 1.98, 6.58 and 9.85 μM, respectively.

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