Cardioactive Terpenoids and a New Rearranged Diterpene from Salvia syriaca

Ayhan Ulubelen; Sevil Öksüz; Ufuk Kolak; Hüsniye Birman; Wolfgang Voelter

doi:10.1055/s-2000-8629

Planta Medica, Table of Contents

Planta Med 2000; 66(7): 627-629
DOI: 10.1055/s-2000-8629

Original Paper

Georg Thieme Verlag Stuttgart · New York

Cardioactive Terpenoids and a New Rearranged Diterpene from Salvia syriaca

Ayhan Ulubelen^1,*, Sevil Öksüz¹ , Ufuk Kolak¹ , Hüsniye Birman² , Wolfgang Voelter³

¹ University of Istanbul, Faculty of Pharmacy, Department of Chemistry, Istanbul, Turkey
² University of Istanbul, Faculty of Medicine, Department of Physiology, Istanbul, Turkey
³ Abteilung für Physikalische Biochemie des Physiologisch-chemischen Instituts, Universität Tübingen, Tübingen, Germany

Abstract

From the roots of Salvia syriaca L., in addition to known terpenoids, a new rearranged diterpene, named salvisyrianone, was isolated. The structure of the new compound was assigned from spectral data. The crude extract and the single compounds were tested for cardiovascular parameters using Wistar Albino rats. Antihypertensive activity was established in the crude extract of the roots as well as in two compounds, ferruginol and 3β-hydroxystigmast-5-en-7-one.

Full Text

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Prof. Dr. Ayhan Ulubelen

Department of Chemistry Faculty of Pharmacy University of Istanbul

34452 Istanbul

Turkey

Phone: +90 212 5193086