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Semin Liver Dis 2000; Volume 20(Number 03): 373-384
DOI: 10.1055/s-2000-9390
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Molecular Alterations in Hepatocyte Transport Mechanisms in Acquired Cholestatic Liver Disorders

JOHN. LEE, JAMES. L. BOYER
  • From the Department of Internal Medicine and Liver Center, Yale University School of Medicine, New Haven, Connecticut
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Publication History

Publication Date:
31 December 2000 (online)

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ABSTRACT

Recent advances in the molecular cloning of membrane transport systems that determine bile formation have facilitated studies of the molecular mechanisms of cholestatic liver disease. The present review summarizes what has been learned about the molecular alterations of these membrane transporters in hepatocytes and cholangiocytes in acquired cholestatic liver disorders. Much of this information has been obtained from the study of animal models of cholestasis and from more limited studies in clinical cholestatic liver diseases. Many of these responses may be interpreted as adaptations that serve to diminish cholestatic liver injury.

KEYWORD

cholestasis - membrane transporters - hepatocyte - cholangiocyte - export pumps

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