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Planta Med 2000; 66(8): 751-753
DOI: 10.1055/s-2000-9563
DOI: 10.1055/s-2000-9563
Letter
© Georg Thieme Verlag Stuttgart · New York
Inhibition of Neutrophil Elastase Activity by Cinnamic Acid Derivatives from Cimicifuga racemosa
Further Information
Publication History
Publication Date:
31 December 2000 (online)
![](https://www.thieme-connect.de/media/plantamedica/200008/lookinside/thumbnails/10.1055-s-2000-9563-1.jpg)
Abstract
Caffeic acid, fukinolic acid as well as cimicifugic acids A, B, E and F isolated from the rhizomes of Cimicifuga racemosa (Ranunculaceae) inhibited the activity of neutrophil elastase (EC 3.4.21.37) in a dose-dependent manner. An IC50 of 93 μmol/L was determined for caffeic acid and 0.23 μmol/L for fukinolic acid. Cimicifugic acid A inhibited the enzyme with an IC50 of 2.2 μmol/L, cimicifugic acid B with 11.4 μmol/L, and cimicifugic acid F with 18 μmol/L. Cimicifugic acid E was only a very weak inhibitor.
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Prof. Dr. Matthias F. Melzig
Institute of Pharmacy Humboldt-University Berlin
Goethestr. 54
13086 Berlin
Germany
Email: matthias=melzig@pharma.hu-berlin.de