Antimycobacterial and Antiplasmodial Cyclodepsipeptides from the Insect Pathogenic Fungus Paecilomyces tenuipes BCC 1614

Abstract

Bioassay-guided fractionation of the crude extract from the insect pathogenic fungus Paecilomyces tenuipes BCC 1614 led to the isolation and identification of two antimycobacterial and antiplasmodial cyclodepsipeptides, beauvericin and beauvericin A.

References

• 1 Hamill  R L,, Higgens  C E,, Boaz  H E,, Gorman  M.. The structure of beauvericin, a new depsipeptide antibiotic toxic to Artemia salina. .  Tetrahedron Letters. 1969;;  4255-8
• 2 Gupta  S,, Krasonoff  S B,, Underwood  N L,, Renwick  J AA,, Roberts  D W.. Isolation of beauvericin as an insect toxin from Fusarium semitectum and Fusarium moniliforme var. subglutinans. .  Mycopathologia. 1991;;  115 185-9
• 3 Gupta  S,, Montllor  C,, Hwang  Y-S.. Isolation of novel beauvericin analogues from the fungus Beauveria bassiana. .  Journal of Natural Products. 1995;;  58 733-8
• 4 Bernardini  M,, Carilli  A,, Pacioni  G,, Santurbano  B.. Isolation of beauvericin from Paecilomyces fumoso-roseus.  Phytochemistry. 1975;;  14 1865
• 5 Deol  B S,, Ridley  D D,, Singh  P.. Isolation of cyclodepsipeptides from plant pathogenic fungi.  Australian Journal of Chemistry. 1978;;  31 1397-9
• 6 Plattner  P A,, Nager  U,, Boller  A.. Über die Isolierung neuartiger Antibiotica aus Fusarien.  Helvetica Chimica Acta. 1948;;  31 594-602
• 7 Grove  J F,, Pople  M.. The insecticidal activity of beauvericin and the enniatin complex.  Mycopathologia. 1980;;  70 103-5
• 8 Collins  L,, Franzblau  S G.. Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium. .  Antimicrobial Agents and Chemotherapy. 1997;;  41 1004-9
• 9 Isaka  M,, Punya  J,, Lertwerawat  Y,, Tanticharoen  M,, Thebtaranonth  Y.. Antimalarial activities of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria.  Journal of Natural Products. 1999;;  62 329-31
• 10 Desjardins  R E,, Canfield  C J,, Chulay  J D.. Quantitative assessment of antimalarial activity in vitro by semiautomated microdilution technique.  Antimicrobial Agents and Chemotherapy. 1979;;  16 710-8
• 11 Likhitwitayawuid  K,, Angerhofer  C K,, Cordell  G A,, Pezzuto  J M.. Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Stephania erecta.  Journal of Natural Products 1993;;  56: 30 - 8.