Planta Med 2001; 67(2): 172-174
DOI: 10.1055/s-2001-11509
Letter

© Georg Thieme Verlag Stuttgart · New York

Cnidicin, a Coumarin, from the Root of Angelica koreana, Inhibits the Degranulation of Mast Cell and the NO Generation in RAW 264.7 Cells

Shi Yong Ryu2 , Na Youn Kou1 , Hong Seok Choi1 , Hyun Ryu1 , Tae Sung Kim1 , Kyeong Man Kim1,*
  • 1 Pharmacology Laboratory; College of Pharmacy, Drug Development Research Center, Chonnam National University, Kwang-Ju, Korea
  • 2 Korea Research Institute of Chemical Technology, Yusung, Taejeon, Korea
Further Information

Publication History

March 30, 2000

July 9, 2000

Publication Date:
31 December 2001 (online)

Abstract

Cnidicin (1) and five related coumarins were isolated from the root extract of Angelica koreana (Umbelliferae) as active principles responsible for the inhibitory effect on the degranulation process of cultured mast cells. Cnidicin (1) demonstrated a significant inhibition upon the release of β-hexosaminidase from the cultured RBL-2H3 cells in a dose dependent manner (IC50 value, 25 μM) and upon the nitric oxide production from the activated RAW264.7 cells (IC50 value, 7.5 μM). In agreement with this, cnidicin inhibited the expression of nitric oxide synthase in RAW264.7 cells.

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Ph. D. Kyeong-Man Kim

Pharmacology Laboratory

College of Pharmacy

Chonnam National University

Kwang-Ju, 500-757

Korea

Email: kmkim@chonnam.chonnam.ac.kr

Fax: +82-62-530-2949