Planta Med 2001; 67(2): 186-188
DOI: 10.1055/s-2001-11517
Letter

© Georg Thieme Verlag Stuttgart · New York

Dihydrochalcones from Piper longicaudatum

A. S. Joshi1 , X.-C. Li1 , A. C. Nimrod1 , H. N. ElSohly1,*, L. A. Walker1, 2 , A. M. Clark1, 3
  • 1 National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi, USA
  • 2 Department of Pharmacology, School of Pharmacy, University of Mississippi, University, Mississippi, USA
  • 3 Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, Mississippi, USA
Further Information

Publication History

March 23, 2000

August 9, 2000

Publication Date:
31 December 2001 (online)

Abstract

Bioactivity-guided fractionation of an ethanolic extract of the leaves and twigs of Piper longicaudatum Trelease & Yunker (Piperaceae) resulted in the isolation of one new (1) and three known (2 - 4) dihydrochalcones. The known compounds are: 2′,6′-dihydroxy-4′-methoxydihydrochalcone (2), 2′,6′,4-trihydroxy-4′-methoxydihydrochalcone (asebogenin) (3), and 2′-hydroxy-4′-methoxy-2′-[1-hydroxy-1-methylethyl]-2″,3″-dihydrofurano[4″,5″: 5′,6″]-3″-[2-hydroxy-5-methoxycarbonylphenyl]dihydrochalcone (piperaduncin B) (4). The new compound is 2′-hydroxy-4′-methoxy-2″-[2-hydroxy-5-methoxycarbonyl-phenyl]-furano[4″,5″ : 5′,6′]-dihydrochalcone (longicaudatin) (1). Compounds 1 - 4 were tested for antibacterial activity against S. aureus and methicillin-resistant S. aureus (MRSA); only compound 3 showed inhibitory activity (IC50 of 10 and 4.5 μg/ml, respectively).

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Dr. Hala N. ElSohly

National Center for Natural Products Research

School of Pharmacy

University of Mississippi

University

MS 38677

USA

Email: helsohly@olemiss.edu

Fax: +1 662-915-7062