Planta Med 2001; 67(3): 277-279
DOI: 10.1055/s-2001-11993
Letter

© Georg Thieme Verlag Stuttgart · New York

Isolation of Virus-Cell Fusion Inhibitory Components from Eugenia caryophyllata

Hyoung Ja Kim1 , Ji Sun Lee1 , Eun-Rhan Woo2 , Min Kyung Kim1 , Beom Seok Yang1 , Yeon Gyu Yu1 ,  Hokoon Park1 , Yong Sup Lee1,*
  • 1 Division of Life Sciences, Korea Institute of Science & Technology, Cheongryang, Seoul, Korea
  • 2 College of Pharmacy, Chosun University, Kwangju, Korea
Further Information

Publication History

April 20, 2000

July 9, 2000

Publication Date:
31 December 2001 (online)

Abstract

The fractionation of Eugenia caryophyllata (Myrtaceae) guided by the syncytia formation inhibition assay led to the isolation of four tannins (eugeniin, casuarictin, 1,3-di-O-galloyl-4,6-(S)-hexahydroxydiphenoyl-β-D-glucopyranose, and tellimagrandin I), and two chromones (biflorin and isobiflorin). Among the isolated compounds, tellimagrandin (4) showed a significantly high inhibitory activity on the syncytia formation with an IC50 value of 16.12 ± 1.98 μg/ml.

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Yong Sup Lee

Korea Institute of Science and Technology

P.O. Box 131

Cheongryang

Seoul 130-650

Korea

Email: yslee@kist.re.kr

Fax: +82-2-958-5189

Phone: Tel: +82-2-958-5167