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Horm Metab Res 2001; 33(2): 96-100
DOI: 10.1055/s-2001-12404
Original Clinical
© Georg Thieme Verlag Stuttgart · New York

Decrease of Hypothalamic Neuropeptide Y Gene Expression by Vanadyl Sulfate in Streptozotocin-Induced Diabetic Rats

I. M. Liu, T. C. Chi, J. T. Cheng
  • Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan
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Publication History

Publication Date:
31 December 2001 (online)

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In an attempt to elucidate the effect of vanadium compounds on the gene expression of neuropeptide Y (NPY), vanadyl sulfate (VOSO4) was orally administrated at the dose of 1 mg/kg body weight into streptozotocin-induced diabetic rats (STZ-diabetic rats) three times daily for 1 week. We found a marked lowering of plasma glucose with a significant decrease of food and water intake in these STZ-diabetic rats treated with VOSO4, although the weight gain was unaffected. The increase of hypothalamic NPY, both the mRNA level and peptide concentration, in STZ-diabetic rats was also reduced by this oral treatment of VOSO4. However, similar treatment of VOSO4 in normal rats failed to modify the feeding behavior and hypothalamic NPY gene expression. These data suggest that decrease of hypothalamic NPY gene expression by VOSO4 is related to the recovery of hyperphagia in diabetic rats lacking insulin.

Key words:

Vanadyl Sulfate - Neuropeptide Y Gene Expression - Diabetic Rat

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Prof. J. T.  Cheng

Department of Pharmacology,
College of Medicine, National Cheng Kung University

Tainan City, Taiwan
70101, R.O.C.


Phone: Phone:+ 886 (6) 237-2706

Fax: Fax:+ 886 (6) 238-6548

Email: E-mail:jtcheng@mail.ncku.edu.tw