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Synthesis 2001(5): 0773-0777
DOI: 10.1055/s-2001-12766
DOI: 10.1055/s-2001-12766
PAPER
© Georg Thieme Verlag Stuttgart · New York
A Synthetic Approach for the Preparation of Rigid Analogs of 1,3-Dipropyl-7-methyl-8-aryl/heteroarylstyryl Xanthines
Further Information
Received
20 November 2000
Publication Date:
15 October 2004 (online)
Publication History
Publication Date:
15 October 2004 (online)
![](https://www.thieme-connect.de/media/synthesis/200105/lookinside/thumbnails/10.1055-s-2001-12766-1.jpg)
Abstract
Tethering the N-8-substituents of N-8-substituted styryl xanthine to N-7 has resulted in a series of conformationally constrained styryl xanthine analogs having the general formula 8. These new compounds have also been evaluated in order to investigate if the A2A adenosine receptor would be able to tolerate such a modification.
Key words
styryl xanthines - photoisomerization - A2A adenosine receptor antagonists - conformationally constrained analogues
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