A Synthetic Approach for the Preparation of Rigid Analogs of 1,3-Dipropyl-7-methyl-8-aryl/heteroarylstyryl Xanthines

Abstract

Tethering the N-8-substituents of N-8-substituted styryl xanthine to N-7 has resulted in a series of conformationally constrained styryl xanthine analogs having the general formula 8. These new compounds have also been evaluated in order to investigate if the A_2A adenosine receptor would be able to tolerate such a modification.

Key words

styryl xanthines - photoisomerization - A_2A adenosine receptor antagonists - conformationally constrained analogues

References

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