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DOI: 10.1055/s-2001-15804
© Georg Thieme Verlag Stuttgart · New York
Neuroprotective Dibenzylbutyrolactone Lignans of Torreya nucifera
Publication History
July 11, 2000
September 17, 2000
Publication Date:
31 December 2001 (online)
![](https://www.thieme-connect.de/media/plantamedica/200105/lookinside/thumbnails/10.1055-s-2001-15804-1.jpg)
Abstract
The methanolic extract of the bark of Torreya nucifera Sieb. et Zucc. (Taxaceae) significantly protected primary cultures of rat cortical cells exposed to the excitotoxic amino acid, L-glutamate. (-)-Arctigenin (1), (-)-traxillagenin (2), arctiin (4), traxillaside (5), and a newly-reported compound 3 (-)-4′-demethyltraxillagenin [(2R,3R)-2-(4″-hydroxy-3″-methoxybenzyl)-3-(4′-hydroxy-3′,5′-dimethoxybenzyl)-butyrolactone] were isolated by bioactivity-guided fractionation and further separation using chromatographic techniques. These lignans and their glycosides had significant neuroprotective activities against glutamate-induced toxicity in primary cultures of rat cortical cells at concentrations ranging from 0.01 μM to 10.0 μM.
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Young Choong Kim, Ph. D.
College of Pharmacy, Seoul National University
San 56-1
Shillim-Dong
Kwanak-Ku
Seoul 151-742
Korea
Email: youngkim@plaza.snu.ac.kr
Fax: +82-2-888-2933Tel.: +82-2-880-7842