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Synthesis 2001(10): 1509-1512
DOI: 10.1055/s-2001-16088
DOI: 10.1055/s-2001-16088
PAPER
© Georg Thieme Verlag Stuttgart · New York
Microwave-Assisted Solid-Support Synthesis of Pyrazolino/Iminopyrimidino/Thioxopyrimidino Imidazolines
Further Information
Received
9 January 2001
Publication Date:
29 September 2004 (online)
Publication History
Publication Date:
29 September 2004 (online)
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Abstract
An expeditious solvent-free synthesis of pyrazolino/iminopyrimidino/thioxopyrimidino imidazoline derivatives from readily accessible oxazolones on solid support using microwaves is described. The reaction time has been brought down from hours to minutes with improved yield as compared to conventional heating.
Key words
microwave irradiation - solid-support synthesis - heterocycles
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References
Aluminium Oxide Basic, Brockmann I (Aldrich Chem. Co., Cat. No. 19, 944-3, ~150 mesh, 58 Å, Surface area 155 m2/g)was used. Alumium Oxide Neutral, Brockmann I (Aldrich Chem. Co., Cat. No. 19, 997-4, ~150 mesh, 58 Å, Surface area 155 m2/g)was used.