Abstract
A new cytotoxic cyclopenta[b]benzofuran derivative, aglaiformosanin (1) and three known cyclopenta[b]benzofuran derivatives (2 - 4) were isolated from the stem bark of Aglaia formosana. Compounds 1 - 4 exhibited potent cytotoxicity against the P-388, KB, HT-29, HL-60, and A549 cell lines. The structure of compound 1 was determined by spectroscopic analysis.
References
-
1
Duh C-Y, Wang S-K, Hou R-S, Wu Y-C, Wang Y, Cheng M-C, Chang T T.
Dehydroodorin, a cytotoxic diamide from the leaves of Aglaia formosana
.
Phytochemistry.
1993;
34
857-8
-
2
Geran R I, Greenberg N H, MacDonald M M, Schumacher A M, Abbott B J.
Protocols for screening chemical agents and natural products against tumors and other biological systems.
Cancer Chemotherapy Reports.
1972;
Part 3 (3)
1-91
-
3
Hou R-S, Duh C-Y, Chiang M Y, Lin C-N.
Sinugibberol, a new cytotoxic cembranoid diterpene from the soft coral Sinulara gibberosa
.
Journal of Naturnal Products.
1995;
58
1126-30
-
4
Kokpol U, Venaskulchai B, Simpson J, Weaver R T.
Isolation and X-ray structure determination of a novel pyrimidinone from Aglaia odorata
.
Journal of Chemical Society, Chemical Communication.
1994;
773-4
-
5
Cui B, Chai H, Santisuk T, Reutrakul V, Fansworth N R, Cordell G A, Pezzuto J M, Kinghorn A D.
Novel cytotoxic 1H-cyclopenta[b]bezofuran lignans from Aglaia elliptica
.
Tetrahedron.
1997;
53
17625-32
-
6
King M-L, Chang C-C, Ling H-C, Fujita E, Ochiai M, McPhail A T.
X-ray crystal structure of rocaglamide, a novel antineukemic 1H-cyclopenta[b]bezofuran from Aglaia elliptifolia
.
Journal of Chemical Society, Chemical Communication.
1982;
1150-1
-
7
Nugroho B W, Edrada R A, Güssrengen V, Wary V, Witte L, Proksch P.
An insecticidal rocaglamide derivatives and related compounds from Aglaia odorata (Meliaceae).
Phytochemistry.
1997;
44
1455-61
-
8
Duh C-Y, Wang S-K, Weng Y-L, Chiang M, Dai C-F.
Cytotoxic terpenoids from the Formosan soft coral Nephthea brassica
.
Journal of Natural Products.
1992;
62
1518-21
-
9
Chen J-J, Duh C-Y, Chen I-S.
New tetrahydroprotobernerine N-oxide alkaloids and cytotoxic constituents of Corydalis tashiroi
.
Planta Medica.
1999;
65
643-7
Prof. Dr. Chang-Yih Duh
Department of Marine Resources
National Sun Yat-sen University
Kaohsiung 804
Taiwan
Republic of China
Email: yihduh@mail.nsysu.edu.tw
Fax: +886-75255020