Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000058.xml
Planta Med 2001; 67(6): 555-557
DOI: 10.1055/s-2001-16471
DOI: 10.1055/s-2001-16471
Letter
© Georg Thieme Verlag Stuttgart · New York
Cytotoxic Cyclopenta[b]benzofuran Derivatives from the Stem Bark of Aglaia formosana
Further Information
Publication History
August 18, 2000
October 22, 2000
Publication Date:
17 August 2001 (online)
Abstract
A new cytotoxic cyclopenta[b]benzofuran derivative, aglaiformosanin (1) and three known cyclopenta[b]benzofuran derivatives (2 - 4) were isolated from the stem bark of Aglaia formosana. Compounds 1 - 4 exhibited potent cytotoxicity against the P-388, KB, HT-29, HL-60, and A549 cell lines. The structure of compound 1 was determined by spectroscopic analysis.
References
- 1 Duh C-Y, Wang S-K, Hou R-S, Wu Y-C, Wang Y, Cheng M-C, Chang T T. Dehydroodorin, a cytotoxic diamide from the leaves of Aglaia formosana . Phytochemistry. 1993; 34 857-8
- 2 Geran R I, Greenberg N H, MacDonald M M, Schumacher A M, Abbott B J. Protocols for screening chemical agents and natural products against tumors and other biological systems. Cancer Chemotherapy Reports. 1972; Part 3 (3) 1-91
- 3 Hou R-S, Duh C-Y, Chiang M Y, Lin C-N. Sinugibberol, a new cytotoxic cembranoid diterpene from the soft coral Sinulara gibberosa . Journal of Naturnal Products. 1995; 58 1126-30
- 4 Kokpol U, Venaskulchai B, Simpson J, Weaver R T. Isolation and X-ray structure determination of a novel pyrimidinone from Aglaia odorata . Journal of Chemical Society, Chemical Communication. 1994; 773-4
- 5 Cui B, Chai H, Santisuk T, Reutrakul V, Fansworth N R, Cordell G A, Pezzuto J M, Kinghorn A D. Novel cytotoxic 1H-cyclopenta[b]bezofuran lignans from Aglaia elliptica . Tetrahedron. 1997; 53 17625-32
- 6 King M-L, Chang C-C, Ling H-C, Fujita E, Ochiai M, McPhail A T. X-ray crystal structure of rocaglamide, a novel antineukemic 1H-cyclopenta[b]bezofuran from Aglaia elliptifolia . Journal of Chemical Society, Chemical Communication. 1982; 1150-1
- 7 Nugroho B W, Edrada R A, Güssrengen V, Wary V, Witte L, Proksch P. An insecticidal rocaglamide derivatives and related compounds from Aglaia odorata (Meliaceae). Phytochemistry. 1997; 44 1455-61
- 8 Duh C-Y, Wang S-K, Weng Y-L, Chiang M, Dai C-F. Cytotoxic terpenoids from the Formosan soft coral Nephthea brassica . Journal of Natural Products. 1992; 62 1518-21
- 9 Chen J-J, Duh C-Y, Chen I-S. New tetrahydroprotobernerine N-oxide alkaloids and cytotoxic constituents of Corydalis tashiroi . Planta Medica. 1999; 65 643-7
Prof. Dr. Chang-Yih Duh
Department of Marine Resources
National Sun Yat-sen University
Kaohsiung 804
Taiwan
Republic of China
Email: yihduh@mail.nsysu.edu.tw
Fax: +886-75255020