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Planta Med 2001; 67(6): 585-587
DOI: 10.1055/s-2001-16477
Letter

© Georg Thieme Verlag Stuttgart · New York

A New Guaianolide as Apoptosis Inhibitor from Chrysanthemum boreale

Jong Rok Lee1 , Min Suk Yang1 , Dae Sik Jang1 , Tae Joung Ha1 , Ki Min Park2 , Choong-Hwan Lee3 , Yung-Hee Kho3 , Ki Hun Park1,*
  • 1 Department of Agricultural Chemistry, Gyeongsang National University, Chinju, Korea
  • 2 The Research Institute of Natural Science, Gyeongsang National University, Chinju, Korea
  • 3 Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Korea
Further Information

Publication History

August 18, 2000

December 2, 2000

Publication Date:
17 August 2001 (online)

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Abstract

The 8-O-acetyl-3,10-dihydroxy-4(15),11(13)-guaiadien-12,6-olide, named borenolide, was isolated from Chrysanthemum boreale M. Borenolide inhibits the etoposide-induced apoptosis in U937 cell with an IC50 value of 6.2 μg/ml. Structural assignment was based on NMR-spectroscopic methods and X-ray crystallographic analysis.

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Prof. Ki Hun Park

Department of Agricultural Chemistry, Gyeongsang

National University

Chinju

Korea 660-701

Email: khpark@gshp.gsnu.ac.kr

Fax: +82-55-757-0178