Neuropediatrics 2001; 32(4): 211-213
DOI: 10.1055/s-2001-17370
Short Communication

Georg Thieme Verlag Stuttgart · New York

Interferon Beta-1a in Children with Multiple Sclerosis is Well Tolerated

E. Waubant, J. Hietpas, T. Stewart, Z. Dyme, J. Herbert, J. Lacy, C. Miller, M. Rensel, S. Schwid, D. Goodkin
  • UCSF/Mt Zion Multiple Sclerosis Center, San Francisco, CA, USA
Further Information

Publication History

Publication Date:
25 September 2001 (online)

Background: Multiple sclerosis is a chronic demyelinating disease rare in children. Currently marketed disease modifying therapies are limited to adults. Objective: To determine the tolerability of interferon beta-1a (IFNB-1 a) 30 mcg injected intramuscularly once a week in children with clinically definite relapsing-remitting multiple sclerosis (RRMS). Design/Methods: A standardized questionnaire was sent to neurologists in the United States to determine the tolerability of IFNB-1 a in patients younger than 16 years. Results: Tolerability data were available for 9 of 33 children who were reported to initiate IFNB-1 a. Mean age on initiating treatment was 12.7 years (range 8 - 15) and mean duration of therapy was 17 months (range 5 - 36). No patient discontinued therapy due to an adverse event. Conclusions: Preliminary data indicate that weekly intramuscular injections of IFNB-1 a are well tolerated.

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M. D. Emmanuelle Waubant

Centre d'Investigation Clinique
Bâtiment Paul Castaigne
Hôpital Pitié-Salpêtrière

47 boulevard de l'Hôpital

75013 Paris

France

Email: emmanuelle.waubant@psl.ap-hop-paris.fr