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Synthesis 2001(12): 1846-1850
DOI: 10.1055/s-2001-17513
PAPER
© Georg Thieme Verlag Stuttgart · New York

Iodine Mediated Lactonization of Terpenic 3-Hydroxy Acids

Tsutomu Fujita*b,, Naoto Hanyua, Takashi Minob, Masami Sakamotoa
a Graduate School of Science and Technology, Chiba University, 1-33, Yayoicho, Inage-ku, Chiba, Japan 263-8522
b Department of Materials Technology, Faculty of Engineering, Chiba University, 1-33, Yayoicho, Inage-ku, Chiba, Japan 263-8522
Fax: +81(43)2903386; e-Mail: fuji@planet.tc.chiba-u.ac.jp;
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Publication History

Received 1 March 2001
Publication Date:
11 August 2004 (online)

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Abstract

Cyclization of terpenic 3-hydroxy acids in the presence of a catalytic amount of iodine gave bicyclic or tricyclic lactones in good yield.

Key words

iodine - lactonization - 3-hydroxy acid - terpenoid - lithium naphthalenide