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Synthesis 2001(12): 1778-1779
DOI: 10.1055/s-2001-17519
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Rofecoxib, (MK 0966, Vioxx ® 4-(4′-Methylsulfonylphenyl)-3-Phenyl-2(5H)-Furanone), a Selective and Orally Active Inhibitor of Cyclooxygenase-2

Michel Thérien*, Jacques Yves Gauthier, Yves Leblanc, Serge Léger, Hélène Perrier, Petpiboon Prasit, Zhaoyin Wang
Merck Frosst Centre for Therapeutic Research, P.O. Box 1005, Pointe Claire - Dorval, Québec, Canada H9R 4P8
Fax: +1(514)4284939; e-Mail: Michel_Therien@Merck.com;
Further Information

Publication History

Received 26 January 2001
Publication Date:
12 August 2004 (online)

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Abstract

The synthesis of Vioxx® (Rofecoxib, MK 966, 4-(4’methylsulfonylphenyl)-3-phenyl-2(5H)-furanone), a newly FDA approved inhibitor of cyclooxygenase-2, is described.

Keywords

lactones - sulfones - anti-inflammatory drugs

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