Orbital Manifestation of Multiple Myeloma: Case Report

Orbital involvement is a rare manifestation of multiple myeloma. Therefore, the correct diagnosis and appropriate management are usually difficult and generally require biopsy. We report a 60-year-old woman having multiple myeloma with orbital involvement. Right orbitozygomatic craniotomy was carried out and the mass lesion was removed. After the histological examination, the diagnosis of multiple myeloma was confirmed. The clinical course and the treatment modalities of this entity are discussed in view of the literature.

Key words:

Multiple Myeloma - Orbit - Surgery

References

• 1 Azar H A. Pathology of multiple myeloma and related growths. In: Azar HA, Potter M, eds. Multiple Myeloma and Related Disorders. Vol. 1 Hagerstown: Harper and Row 1973: 1-26
• 2 Wiltshaw E. The natural history of extramedullary plasmacytoma and its relation to solitary myeloma of bone and myelomatosis.  Medicine. 1976;  55 217-238
• 3 Foerster J. Multiple myeloma. In: Lee R, Bithell T, Foerster J et al. eds. Wintrobe's Clinical Haematology, Vol. 2 Philadelphia, London: Lea and Febiger 1993: 2219-2249
• 4 Howling S J, Tighe J, Patterson K, Shaw P. Case Report: The CT features of orbital multiple myeloma.  Clin Radiol. 1998;  53 304-305
• 5 Levin S R, Spaulding A G, Wirman J A. Multiple myeloma - orbital involvement in a youth.  Arch Ophthalmol. 1977;  95 642-644
• 6 Aboud N, Sullivan T, Whitehead K. Primary extramedullary plasmacytoma of the orbit.  Aust NZ J Ophthalmol. 1995;  23 235-239
• 7 Rodman H I, Font R L. Orbital involvement in multiple myeloma.  Arch Ophthalmol. 1972;  87 30-35
• 8 De Smet M D, Rootman J. Orbital manifestations of plasmacytic lymphoproliferations.  Ophthalmology. 1987;  94 995-1003
• 9 Clarke E. Plasma cell myeloma of the orbit.  Br J Ophthalmol. 1953;  37 543-554
• 10 Rappaport K, Liesegang T J, Menke D H, Czervionke L F. Plasmacytoma manifesting as recurrent cellulitis and hematic cysts of the orbit.  Am J Ophthalmol. 1996;  122 595-597
• 11 Adkins J W, Shields J A, Shields C L, Eagle R C, Campanella P C. Plasmacytoma of the eye and orbit.  Int Ophthalmol. 1996 - 97;  20 339-343
• 12 Gonnering R S. Bilateral primary extramedullary orbital plasmacytomas.  Ophthalmology. 1987;  94 267-270
• 13 Luxenberg M N. Plasmacytoma of the orbit.  Arch Ophthalmol. 1988;  106 1622
• 14 Woodruff R K, Whittle J M, Malpas J S. Solitary plasmacytoma 1: extramedullary soft tissue plasmacytoma.  Cancer. 1979;  43 2340-2343
• 15 Tong D, Griffin T W, Laramore G F. Solitary plasmacytoma of bone and soft tissues.  Radiology. 1980;  135 195-198
• 16 Kyle R. Multiple myeloma review of 869 cases.  Mayo Clin Proc. 1975;  50 29-40
• 17 Macfadzean R M. Orbital plasma cell myeloma.  Br J Ophthalmol. 1975;  59 164-195
• 18 Jonasson F. Orbital plasma cell tumours.  Ophthalmologica. 1978;  177 152-157

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