High Cervical Spinal Cord Stimulation (CSCS) Increases Regional Cerebral Blood Flow After Induced Subarachnoid Haemorrhage in Rats

H. Ebel; K. Schomäcker; A. Balogh; M. Volz; J. Funke; H. Schicha; N. Klug

doi:10.1055/s-2001-18149

min - Minimally Invasive Neurosurgery, Inhaltsverzeichnis

Minim Invasive Neurosurg 2001; 44(3): 167-171
DOI: 10.1055/s-2001-18149

ORIGINAL PAPER

Georg Thieme Verlag Stuttgart · New York

High Cervical Spinal Cord Stimulation (CSCS) Increases Regional Cerebral Blood Flow After Induced Subarachnoid Haemorrhage in Rats

H. Ebel¹ , K. Schomäcker² , A. Balogh³ , M. Volz¹ , J. Funke¹ , H. Schicha² , N. Klug¹

¹Department of Neurosurgery, University of Cologne, Germany
²Department of Nuclear Medicine, University of Cologne, Germany
³Department of Neurosurgery, Debrecen University, Debrecen, Hungary

Abstract

The effects of high cervical spinal cord stimulation (cSCS) on regional cerebral blood flow (rCBF) were investigated after experimentally induced subarachnoid haemorrhage (SAH) in rats by the means of ^99mTc-HMPAO. The experiments were carried out on a total of 24 Wistar rats, divided in three groups [group I: control without SAH, group II: SAH, group III: SAH and cSCS]. ^99mTc-HMPAO was administered intravenously (group II/group III) 48 hours after induction of SAH. In group III, ^99mTc-HMPAO was given after 3 hours of cSCS. All animals were sacrificed 30 minutes after application on ^99mTc-HMPAO. Radioactivities were determined in blood, cerebrum and cerebellum. The ratio cerebrum/blood and cerebellum/blood was calculated to ascertain “extraction rate” in the sample differentially. The following mean values were calculated for the cerebellum/blood ratio: Group I: 1.06, SD: 0.21; Group II: 0.66, SD: 0.21; Group III: 1.00, SD: 0.37. Comparing the mean values a highly significant difference could be found between group II and III (p = 0.007) and between group I and II (p = 0.0019), respectively. Calculations of the cerebrum/blood ratio revealed similar results. After SAH cSCS enhances cerebral and cerebellar blood flow in rats. Possibly, cSCD constitutes a new therapeutic approach in the treatment of disturbed regional cerebral blood flow after SAH.

Key words:

Subarachnoid Haemorrhage - Spinal Cord Stimulation - Regional Cerebral Blood Flow - ^99mTc-HMPAO - Cerebral Vasospasm

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References

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Corresponding Author

Dr. med. H. Ebel

Neurochirurgische Klinik
Universität zu Köln

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50924 Köln

Germany

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eMail: heinrich.ebel@t-online.de