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DOI: 10.1055/s-2001-18344
© Georg Thieme Verlag Stuttgart · New York
Polysomnographic Evaluation of the Hypnotic Effect of Valeriana edulis Standardized Extract in Patients Suffering from Insomnia
Publication History
October 31, 2000
January 21, 2001
Publication Date:
09 November 2001 (online)
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Abstract
Valeriana edulis ssp. procera, commonly known as ”valeriana mexicana”, is widely used in Mexican traditional medicine for the treatment of insomnia and anxiety. To evaluate the hypnotic effect and safety of 450 mg of Valeriana edulis standardized hydroalcoholic extract in patients with insomnia, a double-blind, cross-over, controlled study was carried out. Valeriana officinalis extract, at the same doses, was used as a positive control. In a sleep laboratory, polysomnographic (PSG) recordings were performed for analyzing the quantity and architecture of sleep as well as evaluating morning sleepiness, memory quotient, and side effects. The experimental procedures were conducted on four consecutive nights of 8 h each. Twenty patients were admitted. Based on the PSG results, V. edulis reduced the number of awaking episodes while both treatments increased the rapid eye movement (REM) sleep; this last parameter was better improved by V. officinalis extract. Other PSG data did not achieve outstanding statistical differences, but the clinical tendency with both treatments was to increase the sleep efficiency index. These Valeriana extracts produced beneficial effects on sleep architecture because they diminished the time of stages 1 and 2 in non-REM sleep while they increased delta sleep. Validated clinical tests showed that both species reduced notoriously the morning sleepiness, that was further improved by V. officinalis extract, and did not affect anterograde memory. In only three cases were slight side effects observed, one due to the experimental extract. Chemical analysis of the hydroalcoholic extract of V. edulis indicated that this extract contains 0.26 % of dihydroisovaltrate as the main valepotriate, and that it does not contain valerenic acid. In general, the results support the hypnotic effect and safety of acute treatment of Valeriana edulis and Valeriana officinalis on patients suffering insomnia.
Key words
Valeriana edulis ssp. procera - Valeriana officinalis - Valerianaceae - insomnia - polysomnography - double-blind cross-over study - valepotriates - HPLC analysis
References
-
1 APA (American Psychiatric A ssociation).
Diagnostic and statistical manual of mental disorders. 3rd ed, revised . Washington, D,C; American Psychiatric Press 1987: 355-75 - 2 Stradling J R. ABC of sleep disorders. Recreational drugs and sleep. British Medical Journal. 1993; 306 573-5
- 3 Shapiro C M, Dement W C. ABC of sleep disorders. Impact and epidemiology of sleep disorders. British Medical Journal. 1993; 306 1604-7
- 4 Roth T, Roehrs T A, Stepanski E J, Rosenthal L D. Hypnotics and behavior. American Journal of Medicine. 1990; 88 43-6
-
5 Trease G E, Evans W C.
Farmacognosia . México; Editorial Continental 1984: 687-90 -
6 Martínez M.
Las Plantas Medicinales de México . México; Editorial Andrés Botas 1969: 337-9 - 7 Morazzoni P, Bombardelli E. Valeriana officinalis: traditional use and recent evaluation of activity. Fitoterapia. 1995; 66 99-112
- 8 Hazelhoff B, Malingre T M, Meijer D K. Antiespasmodic effects of valeriana compounds: an in-vivo and in-vitro study on the guinea-pig ileum. Archives Internationales de Pharmacodynamie et de Therapie. 1982; 257 274-87
- 9 Hendriks H, Bos R, Allersma D P, Malingre T M, Koster A S. Pharmacological screening of valeranal and some other components of essential oil of Valeriana officinalis . Planta Medica. 1981; 42 62-8
- 10 Hendriks H, Bos R, Woerdenbag H J, Koster A S. Central nervous depressant activity of valerenic acid in the mouse. Planta Medica. 1985; 1 28-31
- 11 Lindahl O, Lindwall L. Double blind study of a valerian preparation. Pharmacology, Biochemistry and Behavior. 1989; 32 1065-6
- 12 Leathwood P D, Chauffard F. Aqueous extract of valerian reduces latency to fall asleep in man. Planta Medica. 1985; 51 144-8
- 13 Dement W C. Normal sleep, disturbed sleep, transient and persistent insomnia. Acta Psychiatrica Scandinavica Suppl. 1986; 332 41-6
- 14 Schulz H, Stolsz C, Muller J. The effect of valerian extract on sleep polygraphy in poor sleepers: a pilot study. Pharmacopsychiatry. 1994; 27 147-51
- 15 Balderer G, Borbely A A. Effect of valerian on human sleep. Psychopharmacology. 1985; 87 406-9
- 16 Gessner B, Klasser M. Studies on the effect of Harmonicum Much on sleep using polygraphic EEG recordings. EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. 1984; 15 45-51
- 17 Muller-Limmroth W, Ehrenstein W. Experimental studies of the effects of Seda-Kneipp on the sleep of sleep disturbed subjects; implications for the treatment of different sleep disturbances. Medizinische Klinik. 1977; 72 1119-25
- 18 Wechsler D. A Standardized memory scale for clinical use. Journal of Psychology. 1945; 19 87-95
- 19 Leathwood P D, Chauffard F, Heck E, Munoz-Box R. Aqueous extract of valerian root (Valeriana officinalis L .) improves sleep quality in man. Pharmacology, Biochemistry and Behavior. 1982; 17 65-71
- 20 Practice parameters for the use of polysomnography in the evaluation of i nsomnia. Standards of Practice Committee of the American Sleep Disorders Association. Sleep. 1995; 18 55-7
Dr. Jaime Tortoriello
Centro de Investigación Biomédica del Sur. IMSS
Argentina No. 1
Xochitepec
Morelos
México, C.P. 62790
Email: jtortora2@yahoo.es
Fax: (0052) 7 361 21 55