Planta Med 2001; 67(8): 750-751
DOI: 10.1055/s-2001-18347
Letter

© Georg Thieme Verlag Stuttgart · New York

Bakuchiol: A Hepatoprotective Compound of Psoralea corylifolia on Tacrine-Induced Cytotoxicity in Hep G2 Cells

Hyun Cho1 , Jung-Yang Jun1 , Eun-Kyoung Song1 , Ki-Hong Kang1 , Hum-Young Baek2 , Yong-Suk Ko3 , Youn-Chul Kim1,*
  • 1 MRRC and College of Pharmacy, Wonkwang University, Iksan, Korea
  • 2 Jungwoo Pharmaceutical Co., Asan, Chungnam, Korea
  • 3 Korea Food and Drug Administration, Kwangju Regional, Kwangju, Korea
Further Information

Publication History

November 30, 2000

January 21, 2001

Publication Date:
09 November 2001 (online)

Abstract

Bioassay-guided fractionation of the H2O extract of the seeds of Psoralea corylifolia furnished one hepatoprotective compound, bakuchiol (1), together with two moderately active compounds, bakuchicin (2) and psoralen (3), on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC50 values of compounds 1 - 3 are 1.0, 47.0, 50.0 μg/ml, respectively. Silymarin as a positive control showed the EC50 value with 5.0 μg/ml.

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Prof. Dr. Youn-Chul Kim

MRRC and College of Pharmacy

Wonkwang University

Iksan 570-749

Korea