Planta Med 2001; 67(8): 763-765
DOI: 10.1055/s-2001-18360
Letter

© Georg Thieme Verlag Stuttgart · New York

Effect of trans-Dehydrocrotonin, a 19-Nor-Clerodane Diterpene from Croton cajucara on Experimental Hypertriglyceridaemia and Hypercholesterolaemia Induced by Triton WR 1339 (Tyloxapol) in Mice

R. M. Silva1 , F. A. Santos1 , M. A. M. Maciel2 , A. C. Pinto2 , V. S. N. Rao1,*
  • 1 Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil
  • 2 Department of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Further Information

Publication History

November 9, 2000

March 4, 2001

Publication Date:
09 November 2001 (online)

Abstract

The effect of trans-dehydrocrotonin (t-DCTN) from Croton cajucara Benth. was investigated in mice on Triton WR 1339 (tyloxapol)-induced hypercholesterolaemia and hypertriglyceridaemia. Mice treated with single application of tyloxapol (400 mg/kg, i.p.) demonstrated significantly increased blood levels of total cholesterol and triglycerides at 24 h and 48 h after its injection, compared to normal controls. These increases were found to be markedly suppressed in animals treated orally with 25 and 50 mg/kg t-DCTN or 100 mg/kg gemfibrozil, an established antihypercholesterolaemic drug. These results suggest that t-DCTN may be a suitable candidate for combating pathologies associated with hyperlipaemia.

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V. S. N. Rao

Departamento de Fisiologia e Farmacologia

Faculdade de Medicina

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60430-270 Fortaleza

CE, Brasil

Email: vietrao@ufc.br

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