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Planta Med 2001; 67(8): 763-765
DOI: 10.1055/s-2001-18360
Letter

© Georg Thieme Verlag Stuttgart · New York

Effect of trans-Dehydrocrotonin, a 19-Nor-Clerodane Diterpene from Croton cajucara on Experimental Hypertriglyceridaemia and Hypercholesterolaemia Induced by Triton WR 1339 (Tyloxapol) in Mice

R. M. Silva1 , F. A. Santos1 , M. A. M. Maciel2 , A. C. Pinto2 , V. S. N. Rao1,*
  • 1 Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil
  • 2 Department of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
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Publication History

November 9, 2000

March 4, 2001

Publication Date:
09 November 2001 (online)

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Abstract

The effect of trans-dehydrocrotonin (t-DCTN) from Croton cajucara Benth. was investigated in mice on Triton WR 1339 (tyloxapol)-induced hypercholesterolaemia and hypertriglyceridaemia. Mice treated with single application of tyloxapol (400 mg/kg, i.p.) demonstrated significantly increased blood levels of total cholesterol and triglycerides at 24 h and 48 h after its injection, compared to normal controls. These increases were found to be markedly suppressed in animals treated orally with 25 and 50 mg/kg t-DCTN or 100 mg/kg gemfibrozil, an established antihypercholesterolaemic drug. These results suggest that t-DCTN may be a suitable candidate for combating pathologies associated with hyperlipaemia.

References

  • 1 Choi J S, Suh S S, Young H S, Park H J. Antihyperlipidaemic effect of flavonoids from Prunus davidiana .  Archives of Pharmacological Research. 1991;  14 44-7
    PubMedSearch in Google Scholar
  • 2 La Cour B, Molgaard P, Yi Z. Traditional Chinese Medicine in treatment of hyperlipidaemia.  Journal of Ethnopharmacology. 1995;  46 125-9
    CrossrefPubMedSearch in Google Scholar
  • 3 Craig W J. Health promoting properties of common herbs.  American Journal of Clinical Nutrition. 1999;  70 (Suppl 3) 491S-9S
    PubMedSearch in Google Scholar
  • 4 Wang H X, Ng T B. Natural products with hypoglycemic, hypotensive, hypocholesterolemic, antiatherosclerotic and antithrombotic activities.  Life Sciences. 1999;  65 2663-77
    CrossrefPubMedSearch in Google Scholar
  • 5 Di Stasi L C, Santos E MG, Santor C M, Hiruima C A. Plantas Medicinais da Amazônia. São Paulo; UNESP 1989: 127-8
    Search in Google Scholar
  • 6 Farias R AF, Neto M FO, Viana G SB, Rao V SN. Effects of C. cajucara extract on serum lipids of rats fed a high fat diet.  Phytotherapy Research. 1996;  10 697-9
    CrossrefPubMedSearch in Google Scholar
  • 7 Maciel M AM, Pinto A C, Brabo S N, Silva M N. Terpenoids from C. cajucara .  Phytochemistry. 1998;  49 823-8
    CrossrefPubMedSearch in Google Scholar
  • 8 Carvalho J C, Silva M F, Maciel M AM, Pinto A C, Nunes D S, Lima R M et al. Investigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from C. cajucara. Part 1.  Planta Medica. 1996;  62 402-4
    PubMedSearch in Google Scholar
  • 9 Maciel M AM, Pinto A C, Arruda A C, Pamplona S GSR, Vanderlinde F A, Lapa A J et al. Ethnopharmacology, phytochemistry and pharmacology: a successful combination in the study of Croton cajucara .  Journal of Ethnopharmacology. 2000;  70 41-55
    CrossrefPubMedSearch in Google Scholar
  • 10 Farias R AF, Rao V SN, Viana G SB, Silveira E R, Maciel M AM, Pinto A C. Hypoglycemic effect of trans-dehydrocrotonin, a nor-clerodane diterpene from Croton cajucara .  Planta Medica. 1997;  66 558-60
    PubMedSearch in Google Scholar
  • 11 Hall J A, Gradin J L, Andreasen C B, Wander R C. Use of nonionic detergent (Triton WR 1339) in health to assess hepatic secretion of triglycerides.  American Journal of Veterinary Research. 2000;  61 941-50
    PubMedSearch in Google Scholar
  • 12 Nagao K, Sakono M, Nakayama M, Hirakawa T, Imaizumi K. Effect of gemfibrozil on triacylglycerol synthesis and secretion by liver and lipoprotein lipase activity in adipose tissue of rats.  Comparative Biochemistry and Physiology. 1999;  124 289-94
    PubMedSearch in Google Scholar
  • 13 Tsi D, Das N P, Tan B KH. Effects of aqueous colery (Apium graveolens) extract on lipid parameters of rats fed a high fat diet.  Planta Medica. 1995;  61 18-21
    PubMedSearch in Google Scholar
  • 14 Fattore P C, Sirtori C R. Nicotinic acid and derivatives.  Current Opinion in Lipidology. 1991;  2 43-7
    PubMedSearch in Google Scholar
  • 15 Kunjathoor V V, Wilson D L, LeBoeuf R C. Increased atherosclerosis in streptozotocin-induced diabetic mice.  Journal of Clinical Investigation. 1996;  97 1767-73
    PubMedSearch in Google Scholar
  • 16 Agner A R, Maciel M AM, Pinto A C, Pamplona S GSR, Cólus I MS. Investigation of genotoxic activity of trans-dehydrocrotonin, a clerodane diterpene from Cróton cajucara .  Teratogenesis Carcinogenesis and Mutagenesis. 1999;  19 377-84
    CrossrefPubMedSearch in Google Scholar
  • 17 Allain C C, Poon L S, Chan C SG, Richmond W, Fu P C. Enzymatic determination of total serum cholesterol.  Clinical chemistry. 1974;  20 470-5
    PubMedSearch in Google Scholar
  • 18 Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes.  Clinical Chemistry. 1973;  19 476-82
    PubMedSearch in Google Scholar
  • 19 Warnick G R, Cheung M C, Albers J J. Comparation of current methods for high-density lipoprotein cholesterol quantitation.  Clinical Chemistry. 1979;  25 596-604
    PubMedSearch in Google Scholar

V. S. N. Rao

Departamento de Fisiologia e Farmacologia

Faculdade de Medicina

Rua Cel. Nunes de Melo, 1127

Caixa Postal 3157

60430-270 Fortaleza

CE, Brasil

Email: vietrao@ufc.br

Fax: +55 85 288 8333

Phone: Tel.: +55 85 288 8341