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Synthesis 2002(1): 0133-0137
DOI: 10.1055/s-2002-19313
PAPER
© Georg Thieme Verlag Stuttgart · New York

Efficient Syntheses of New CF3-containing Diazolopyrimidines

Arcady L. Krasovsky, Anton S. Hartulyari, Valentine G. Nenajdenko*, Elizabeth S. Balenkova
Department of Chemistry , Moscow State University , 119899 Moscow, Russia
Fax: +7(95)9328846; e-Mail: Nen@acylium.chem.msu.su;
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Publication History

Received 1 August 2001
Publication Date:
04 August 2004 (online)

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Abstract

A new simple and efficient way to CF3-containing pyrimido[1,2-a]benzimidazole and pyrazolo[1,5-a]pyrimidines, by the reaction of 1,1,1-trifluoro-4-sulfonyl-but-3-ene-2,2-dioles 1a,b with aminoheterocycles is described. The influence of reaction conditions and nature of the aminoheterocycles on regiochemistry was investigated.

Key words

cycloaddition - heterocycles - pyrimido[1,2-a]benzimidazole - pyrazolo[1,5-a]pyrimidines - sulfones

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Krasovsky, A. L.; Nenajdenko, V. G.; Balenkova, E. S.; Synthesis 2001 in press.