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DOI: 10.1055/s-2002-20055
© Georg Thieme Verlag Stuttgart · New York
Evaluation of Antimycobacterial, Antiplasmodial and Cytotoxic Activities of Preussomerins Isolated from the Lichenicolous Fungus Microsphaeropsis sp. BCC 3050
Publication History
January 8, 2001
June 9, 2001
Publication Date:
31 January 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200201/lookinside/thumbnails/10.1055-s-2002-20055-1.jpg)
Abstract
A new preussomerin isomer, 3′-O-demethylpreussomerin I, five known preussomerins E - I, and two known deoxypreussomerins, deoxypreussomerin A and bipendensin (palmarumycin C11), were isolated from a lichenicolous fungus Microsphaeropsis sp. BCC 3050. These structures were elucidated by spectroscopic methods, especially 1D- and 2D-NMR. The preussomerins were evaluated for their antimycobacterial and antiplasmodial activities as well as cytotoxicity against KB, BC-1 and vero cell lines.
Key words
Microsphaeropsis sp. - lichenicolous fungi - preussomerins - antiplasmodial activity - antimycobacterial activity
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Dr. Masahiko Isaka
National Center for Genetic Engineering and Biotechnology (BIOTEC)
National Science and Technology Development Agency (NSTDA)
Rama 6 Road
Bangkok 10400
Thailand
Email: isaka@biotec.or.th