Inhibition of HIV-1 Reverse Transcriptase and HIV-1 Replication by Calophyllum Coumarins and Xanthones

H. R. W. Dharmaratne; G. T. Tan; G. P. K. Marasinghe; J. M. Pezzuto

doi:10.1055/s-2002-20058

Planta Medica, Table of Contents

Planta Med 2002; 68(1): 86-87
DOI: 10.1055/s-2002-20058

Letter

Inhibition of HIV-1 Reverse Transcriptase and HIV-1 Replication by Calophyllum Coumarins and Xanthones

H. R.W. Dharmaratne¹ , G. T. Tan² , G. P.K. Marasinghe¹ , J. M. Pezzuto²

¹1 Natural Products Programme, Institute of Fundamental Studies, Kandy, Sri Lanka
²2 Programme for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Chicago, Illinois, U.S.A.

Abstract

As part of our continuing study on the Calophyllum species, a number of coumarins, xanthones and chromene acids from different Calophyllum species of Sri Lanka were tested for inhibitory activity against the HIV-1 and its virally-encoded reverse transcriptase (RT). These compounds were found to be inactive in both the HIV-1 RT and whole virus systems. In contrast, cordatolide A and B demonstrated IC₅₀ values of 19.3 and 11.7 μM, respectively, against HIV-1 replication in a novel green fluorescent protein (GFP)-based reporter cell assay (HOG.R5).

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References

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Dr. H. R. W. Dharmaratne

Natural Products Propgramme

Institute of Fundamental Studies

Kandy

Sri Lanka

Email: hrwd13@hotmail.com

Fax: 94 - 8 232131