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Planta Med 2002; 68(3): 244-248
DOI: 10.1055/s-2002-23135
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

New Macrocyclic Diterpenoids from Euphorbia esula

L. G. Liu1 , J. C. Meng1 , S. X. Wu2 , X. Y. Li3 , X. C. Zhao3 , R. X. Tan1
  • 1Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing, People′s Republic of China
  • 2NMR Center, Department of Chemistry, Emory University, Atlanta, Georgia, USA
  • 3National Xin-Zhong Laboratory for Drug Screening, Nanjing, People′s Republic of China
Further Information

Publication History

April 6, 2001

August 4, 2001

Publication Date:
25 March 2002 (online)

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Abstract

The structures of two new macrocyclic jatrophane diterpenoid esters from the whole herb of Euphorbia esula, were established as 11,14-epoxy-3β,5α,7β,8α,9α,15β-hexaacetoxy-12-oxo-13αH-jatropha-6(17)-ene (1) and 1α,3β-diacetoxy-5α,7β-dibenzoyloxy-9,14-dioxo-11β,12α-epoxy-2α,8α,15β-trihydroxy-13βH-jatropha-6(17)-ene (2) by a combination of 1D- and 2D-NMR techniques as well as UV, IR and mass spectral data. Bioassay evaluation of all isolates against the human tumor cell lines (B16, KB, SMMC and BGC) indicated that ester 2 was cytotoxic to B16 with the IC50 value being 1.81 μg/ml. In addition, the irritant activity assay indicated that both diterpenoids were inactive (ID24 50 > 100 μg/ear).

Key words

Euphorbia esula L. - Euphorbiacae - jatrophane diterpenoid esters - irritation - cytotoxicity

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Prof. R. X. Tan

Institute of Functional Biomolecules

School of Life Sciences

Nanjing University

Nanjing 210093

People’s Republic of China

Email: rxtan@netra.nju.edu.cn

Phone: and Fax: +86-25-3593201