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Synlett 2002(5): 0820-0822
DOI: 10.1055/s-2002-25344
DOI: 10.1055/s-2002-25344
LETTER
© Georg Thieme Verlag Stuttgart · New York
A Rapid Entry to Natural and Unnatural Disubstituted Maleic Anhydrides
Further Information
Received
19 March 2002
Publication Date:
07 February 2007 (online)
Publication History
Publication Date:
07 February 2007 (online)
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Abstract
Copper-mediated tandem vicinal difunctionalisation of dimethyl acetylenedicarboxylate, followed in selected cases by oxidation of one of the substituents, provides a versatile and rapid route to a variety of natural and unnatural disubstituted maleic anhydrides.
Key words
conjugate additions - copper - maleic anhydrides - natural products - tandem reactions
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References
New address: R. J. Cox, Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
14All new compounds described in this communication have been fully characterised by 1H and 13C NMR, IR, mass spectroscopy and HRMS.