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DOI: 10.1055/s-2002-26741
© Georg Thieme Verlag Stuttgart · New York
The Effects of Higenamine on LPS-Induced
Experimental Disseminated Intravascular Coagulation (DIC) in Rats
Publication History
June 27, 2001
August 25, 2001
Publication Date:
02 May 2002 (online)
![](https://www.thieme-connect.de/media/plantamedica/200204/lookinside/thumbnails/10.1055-s-2002-26741-1.jpg)
Abstract
The effect of higenamine, a benzyl-tetrahydroisoquinoline alkaloid of the roots of Aconitum spp. (Ranunculaceae), on disseminated intravascular coagulation (DIC), was investigated using an experimental DIC rat model. The oral administration of higenamine (10 mg/kg or 50 mg/kg), significantly ameliorated the decrease of fibrinogen level in plasma, the increase of fibrinogen/fibrin degradation product (FDP) level, and the prolongation of prothrombin time (PT) induced by the i. v. infusion of lipopolysaccharide (LPS). The prolongation of activated partial thrombin time (aPTT) and the decrease of platelet count were suppressed. The increase in serum aspartate aminotransferase (AST) and blood urea nitrogen (BUN) were also significantly prevented with higenamine. The above results are suggestive that higenamine has therapeutic potential for DIC and/or accompanying multiple organ failure (MOF).
Key words
Higenamine - benzyl-tetrahydroisoquinoline - Aconitum spp. - Ranunculaceae - disseminated intravascular coagulation (DIC) - multiple organ failure (MOF)
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Hye Sook Yun-Choi
Natural Products Research Institute
Seoul National University
Seoul 110-460, Korea
Phone: +82-2-740-8901
Fax: +82-2-742-9951
Email: hsyun@snu.ac.kr