Abstract
The topical anti-inflammatory activity of Haplophyllum hispanicum Spach is due to the presence of arylnaphthalene-type lignans acting as 5-lipoxygenase (5-LOX) inhibitors. The effects of the methanolic extract of this species on cellular systems have been determined by HPLC-DAD analysis. Diphyllin acetylapioside proved to be the main lignan endowed with 5-LOX inhibitory activity.
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Prof. José L. Ríos Cañavate
Departament Farmacologia, Universitat de València.
Avda. Vicent Andrés Estellés s/n
46100 Burjassot, Spain
Phone: /Fax: +34-963864973
Email: riosjl@uv.es
