Abstract
Fractionation of the MeOH extract of Angelica dahurica Benth et Hook resulted in the isolation of six furocoumarins, imperatorin (1), isoimperatorin (2), (±)-byakangelicol (3), (+)-oxypeucedanin (4), (+)-byakangelicin (5), and (+)-aviprin (6). Among these, compounds 1 and 5 exhibited strong hepatoprotective activities, displaying EC50 values of 36.6 ± 0.98 and 47.9 ± 4.6 μM, respectively. Compounds 3 and 4 showed moderate activities with EC50 values of 112.7 ± 5.35 and 286.7 ± 6.36 μM, respectively. Silybin as a positive control showed the EC50 value with 69.0 ± 3.4 μM. Comparison of hepatoprotective activities for six furocoumarins 1 - 6 suggested that oxy-substitution at the C-9 position increased the hepatoprotective activity.
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Prof. Young-Gab Yun
Medicinal Resources Research Center
Wonkwang University
Iksan, Chonbuk 570-749, Korea
Email: yunyg@wonkwang.ac.kr
Fax: +82-63-856-5056
