Planta Med 2002; 68(6): 539-541
DOI: 10.1055/s-2002-32547
Letter
© Georg Thieme Verlag Stuttgart · New York

Antiviral and Antioxidant Activity of Flavonoids and Proanthocyanidins from Crataegus sinaica

Abdelaaty A. Shahat1, 2 , Paul Cos2 , Tess De Bruyne2 , Sandra Apers2 , Fayza M. Hammouda1 , Shams I. Ismail1 , Safa Azzam1 , Magda Claeys2 , Etienne Goovaerts3 , Luc Pieters2 , Dirk Vanden Berghe2 , Arnold J. Vlietinck2
  • 1Pharmacognosy and Chemistry of Medicinal Plants Department, NRC, Dokki, Cairo, Egypt
  • 2Faculty of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium
  • 3Department of Physics, University of Antwerp, Antwerp, Belgium
Further Information

Publication History

August 16, 2001

October 30, 2001

Publication Date:
01 July 2002 (online)

Abstract

The antiviral and antioxidant activity of some fractions and of a series of flavonoids and proanthocyanidins obtained from Crataegus sinaica (Rosaceae) was evaluated. The O-glycosidic flavonoids and the oligomeric proanthocyanidins exhibited significant inhibitory activity against herpes simplex virus type 1 (HSV-1), which was shown to be due to an extracellular mechanism for procyanidin C-1. Procyanidin C-1 also had the highest antioxidant activity in both the microsomal lipid peroxidation and the hydroxyl radical scavenging assay. In addition to the previously reported phenolic compounds, the pentacyclic triterpenoid ursolic acid (1) and a tetrameric (2) and pentameric procyanidin (3) are reported for the first time.

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Prof. Dr. L. Pieters

Department of Pharmaceutical Sciences

University of Antwerp

Universiteitsplein 1

2610 Antwerp, Belgium

Email: pieters@uia.ua.ac.be

Fax: (+32) 3 820 27 09