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Planta Med 2002; 68(6): 523-527
DOI: 10.1055/s-2002-32549
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Pharmacologically Active Ellagitannins from Terminalia myriocarpa

Mohamed S.A. Marzouk1 , Sayed A.A. El-Toumy1 , Fatma A. Moharram2 , Nagwa M.M. Shalaby  3 , Amany A.E. Ahmed  4
  • 1Chemistry of Tannins and Proteins Department, National Research Centre, Cairo, Egypt
  • 2Pharmacognosy Department, Faculty of Pharmacy, Helwan University, Ain Helwan, Egypt
  • 3Chemistry of Natural Product Department, National Research Centre, Cairo, Egypt
  • 4Pharmacology and Toxicology Department, Faculty of Pharmacy, Helwan University, Ain Helwan, Egypt
Further Information

Publication History

August 10, 2001

December 2, 2001

Publication Date:
01 July 2002 (online)

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Abstract

A new ellagitannin, methyl (S)-flavogallonate (14) along with fourteen known compounds, gallic acid, methyl gallate, ethyl gallate, 2,3-di-O-[(S)-4,5,6,4′,5′,6′-hexahydroxybiphenyl-2,2′-diyldicarbonyl]-(α/β)-D-glucopyranose (4), vitexin, isovitexin, orientin, iso-orientin, kaempferol 3-O-β-D-rutinoside, rutin, neosaponarin, ellagic acid, flavogallonic acid (13), and (α/β)-punicalagin (15) have been isolated from the leaves of Terminalia myriocarpa Heurck. Protective effect of the major and structurally related compounds 4, 13, 15 and the new compound 14 against CCl4-induced hepatotoxicity has been evaluated and compared, using adult male rats weighing 200 - 250 g. Serum levels of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), lipid peroxide and nitric oxide production were significantly increased by administration of CCl4 to rats and then reduced significantly only by treatment with compounds 4, 14 and 15 in a dose-dependent manner. Comparison of the protective properties of these compounds showed that compound 14 is more potent than compound 15 than 4 and that compound 13 has a non-significant effect at the used two dose levels.

Key words

Terminalia myriocarpa - Combretaceae - CCl4-induced hepatotoxicity - hepatoprotective activity - nitric oxide - lipid peroxidation

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Dr. Nagwa M.M. Shalaby

Chemistry of Natural Product Department

National Research Centre

El-Tahrir St.

Dokki

Cairo

Egypt

Email: nmshalaby@hotmail.com

Phone: +202 3669927

Fax: +2023370931