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Planta Med 2002; 68(6): 515-518
DOI: 10.1055/s-2002-32570
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Antiulcerogenic Activity of Some Sesquiterpene Lactones Isolated from Artemisia annua

Mary Ann Foglio1 , Patrícia Corrêa Dias1, 2 , Marcia Aparecida Antônio1, 2 , Ana Possenti1 , Rodney Alexandre Ferreira Rodrigues1 , Érica Ferreira da Silva1 , Vera Lúcia Garcia Rehder1 , João Ernesto de Carvalho1, 2
  • 1Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas da Universidade Estadual de Campinas (CPQBA/UNICAMP), Campinas, SP, Brazil
  • 2Departamento de Clínica Médica da Faculdade de Ciências Médicas da Universidade Estadual de Campinas (FCM/UNICAMP), Campinas, SP, Brazil
Further Information

Publication History

August 24, 2001

March 23, 2002

Publication Date:
01 July 2002 (online)

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Abstract

Artemisinin 1, dihydro-epideoxyarteannuin B 2 and deoxyartemisinin 3 were isolated from the sequiterpene lactone-enriched fraction obtained from the crude ethanolic extract of Artemisia annua L. These compounds were tested on ethanol and indomethacin-induced ulcer models. Compound 1 did not afford cytoprotection under the experimental models tested. Only compounds 2 and 3 decreased the ulcerative lesion index produced by ethanol and indomethacin in rats. These compounds did not demonstrate antiulcerogenic activity when tested on the ethanol-induced ulcer model, with previous administration of indomethacin, suggesting that the antiulcerogenic activity is a consequence of prostaglandin synthesis increase.

Key words

Artemisia annua - Asteraceae - antiulcer activity - sesquiterpenes

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Dr. Mary Ann Foglio

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CEP 13081 970 Campinas

São Paulo

Brazil

Phone: +(005519) 3884-7500

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Email: foglioma@cpqba.unicamp.br