Thorac Cardiovasc Surg 2002; 50(4): 201-203
DOI: 10.1055/s-2002-33102
Original Cardiovascular
Original Paper
© Georg Thieme Verlag Stuttgart · New York

Does Cardiopulmonary Bypass Alter Plasma Level of Tumor Markers? CA 125 and Carcinoembryonic Antigen

B.  Battaloglu1 , E.  Kaya2 , N.  Erdil1 , V.  Nisanoglu1 , F.  Kosar3 , B.  Ozgur1 , B.  Yıldırım4 , H.  Karagoz5
  • 1Inonu University, Turgut Ozal Medical Center, Dept. of Cardiovascular Surgery, Malatya, Turkey
  • 2Inonu University, Turgut Ozal Medical Center, Dept. of Hematology, Malatya, Turkey
  • 3Inonu University, Turgut Ozal Medical Center, Dept. of Cardiology, Malatya, Turkey
  • 4Inonu University, Turgut Ozal Medical Center, Dept. of Gastroenterology, Malatya, Turkey
  • 5Guven Hospital, Dept. of Cardiovascular Surgery, Ankara, Turkey
Further Information

Publication History

Publication Date:
07 August 2002 (online)

Abstract

Background: In addition to malignant diseases, acute and chronic inflammations may elevate plasma levels of tumor markers CA 125 and carcinoembryonic antigen (CEA). Cardiopulmonary bypass (CPB) causes a generalized inflammatory response. In this study, we have investigated the effect of CPB on plasma levels of CA 125 and CEA. Methods: We measured plasma levels of CA 125 and CEA in patients undergoing coronary artery bypass grafting (CABG) with CPB (Group 1, n = 21), and in patients who underwent off-pump CABG, that is, without CPB (Group 2, n = 16). Blood samples were collected preoperatively, and on postoperative days 1, 6, and 12. Results: Within both groups, CEA plasma levels were not significantly influenced in any samples. Comparing with preoperative values, CA 125 values elevated significantly on postoperative days 6 and 12 within both groups. It was observed that the elevation of CA 125 plasma levels in these samples were significantly higher in Group 1. Conclusions: The results indicate that CPB elevated plasma level of CA 125. However, clinical importance of this finding needed further evaluation.

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MD Bektas Battaloglu

Inonu University, Turgut Ozal Medical Center, Dept. of Cardiovascular Surgery


44069 Malatya

Taipei, Taiwan

Turkey

Phone: +90 (422) 341 06 60

Fax: +90 (422) 341 07 28

Email: bebat@superonline.com