Rapid Microwave-Assisted Solid Phase Peptide Synthesis

Máté  Erdélyi; Adolf  Gogoll

doi:10.1055/s-2002-33348

SPECIALTOPIC

Rapid Microwave-Assisted Solid Phase Peptide Synthesis

Máté Erdélyi^a,b, Adolf Gogoll*^a
^a Department of Organic Chemistry, Uppsala University, Box 531, 751 21 Uppsala, Sweden
Fax: +46(18)512524; e-Mail: mate@kemi.uu.se, adolf@kemi.uu.se;
^b Department of Medicinal Chemistry, Uppsala University, Box 574, 751 23 Uppsala, Sweden
Fax: +46(18)4714474;

Abstract

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Abstract

A microwave-assisted, rapid solid phase peptide synthesis procedure is presented. It has been applied to the coupling of sterically hindered Fmoc-protected amino acids yielding di- and tripeptides. Optimized conditions for a variety of coupling reagents are reported. Peptides were obtained rapidly (1.5-20 min) and without racemization.

Key words

SPPS - microwave - amino acids - peptide coupling - solid-phase

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